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Targeted Ultrasmall Particle Imaging Platforms as Next-Generation Treatment Tools for Drug Delivery and Induction of Cell Death
April 12, 2018 @ 10:30 am - 11:30 am
Michelle S. Bradbury MD, PhD, from Memorial Sloan Kettering Cancer Center
“Targeted Ultrasmall Particle Imaging Platforms as Next-Generation Treatment Tools for Drug Delivery and Induction of Cell Death.”
Advances in nanotechnology have also fueled a paradigm shift in targeting and safely delivering drugs in conjunction with image-directed approaches. The size, architecture, and chemical composition of particle-based drug delivery vehicles can be fine-tuned to achieve properties optimal for loading and controlled release of therapeutic agents, patient safety/compliance, favorable kinetic profiles, and reducing unwanted side effects. By combining therapeutic particle tracer preparations with quantitative bioimaging approaches, drug delivery, lesion localization, and the extraction of key tumor biologic properties can be achieved for individualizing treatment planning. In turn, dosage regimens needed to achieve therapeutic efficacy might be estimated based on knowledge of drug specific activity and dose, uptake kinetics, and IC50 values.
Breakfast will be served.