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UNC Lineberger Comprehensive Cancer Center

Research

Research flow chart illustrating the bidirectional flow between phase 1 clinical trial development, pre-clinical studies in tumor models, and bioinformatic validation studies. Further details in paragraph text.Our work utilizes a variety of techniques and methodologies that span the breadth of basic biological research.

This work integrates studies based on:

  • Transgenic mouse tumor models that are monitored using bioluminescence and micro-CT imaging
  • A variety of clinical specimens
  • Various bioinformatic approaches.

Our current areas of focus include:

  • Investigating mechanisms of adaptive or acquired immunotherapy resistance in cancer
  • Elucidating mechanisms of dendritic cell tolerization in the tumor microenvironment and how these processes may contribute to immunotherapy resistance
  • Understanding the underlying mechanisms involved in EMT-associated tumor immune evasion
  • Development of novel pharmacologic and genetic strategies to overcome immunotherapy resistance
  • Investigating mechanisms contributing to select immunotherapy-associated toxicities