UNC Lineberger’s Joseph G. Ibrahim, PhD, Alumni Distinguished Professor in the UNC Gillings School of Global Public Health Department of Biostatistics and director of the UNC Lineberger Biostatistics Core, and Jen Jen Yeh, MD, professor of pharmacology and surgery in the UNC School of Medicine, and vice chair for research in the Department of Surgery were published in the Journal of the American Statistical Association.
In the article, which was led by Naim Rashid, PhD, assistant professor in the UNC Gillings School of Global Public Health, researchers reported on a method of improving selection of gene signatures for diseases.
While gene signatures are used to predict outcomes from treatment for patients and to help guide treatment decisions, researchers reported that gene signatures aren’t often reproducible across studies.
Researchers introduced a new system to address this problem, and demonstrated the use of their method by subtyping cancer tumor samples drawn from four different studies of gene expression.
In addition to Ibrahim, Rashid and Yeh, Quefeng Li, PhD, assistant professor in the UNC Gillings School of Global Public Health Department of Biostatistics, was also an author on the paper.