A selective listing of clinical trials for brain and central nervous system cancers that are currently available at UNC Lineberger Comprehensive Cancer Center.

Study Phase Study # Study Title and Description Principal Investigator
Phase II A071401-CIRB Phase II Trial of SMO/AKT/NF2 inhibitors in Progressive Meningiomas with SMO/AKT/NF2 Mutations Frances Collichio, MD
Phase III EF-25 Pivotal, Open-Label, Randomized Study of Radiosurgery with or without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases from Non-small Cell Lung Cancer (NSCLC) Simon Khagi, MD
Phase III OT-15-001 A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy Simon Khagi, MD
Phase III NCT02831959 Effect of TTFields (150 kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-10 Brain Metastases Following Radiosurgery (METIS) Simon Khagi, MD