UNC Lineberger News

UNC Lineberger joins with Teen Cancer America, First Citizens Bank to announce plans for teen, young adult cancer program

UNC Lineberger joins with Teen Cancer America, First Citizens Bank to announce plans for teen, young adult cancer program

Gift from Teen Cancer America and First Citizens Bank will help UNC Lineberger to enhance its Adolescent and Young Adult cancer program, including expanding its research program focused on teens and young adults and developing plans for space tailored to this patient group.

UNC Lineberger joins with Teen Cancer America, First Citizens Bank to announce plans for teen, young adult cancer program - Read More…

UNC researchers identify promising delivery method for immunotherapy combination

UNC researchers identify promising delivery method for immunotherapy combination

UNC Lineberger researchers led by Andrew Z. Wang, associate professor in the UNC School of Medicine Department of Radiation Oncology, believe findings, published in the journal Advanced Materials, offer a promising new nanotechnology-based delivery method for an immunotherapy combination.

UNC researchers identify promising delivery method for immunotherapy combination - Read More…

Carolina receives $10 million commitment from the Pope Foundation

Carolina receives $10 million commitment from the Pope Foundation

The donation will provide support for UNC Lineberger Comprehensive Cancer Center, UNC Horizons, the track and field program, and the Philosophy, Politics and Economics Program.

Carolina receives $10 million commitment from the Pope Foundation - Read More…

UNC scientists create better laboratory tools to study cancer’s spread

UNC scientists create better laboratory tools to study cancer’s spread

In the journal Nature Biomedical Engineering, UNC Lineberger’s Andrew Wang, MD, and colleagues report they have developed tissue-engineered models for cancer metastases that reflect the microenvironment around tumors that promotes their growth. They believe their models, which were developed to study colorectal cancer that had spread to the liver and lung, will help scientists studying why cancers tend to spread to certain organs rather than others.

UNC scientists create better laboratory tools to study cancer’s spread - Read More…

Cigarillo packaging can influence product perception, study finds

Cigarillo packaging can influence product perception, study finds

Researchers led by UNC Lineberger's Adam Goldstein, MD, and Clare Meernik, MPH, surveyed 2,664 young adults who were current users, never users, or past users of little cigars and cigarillos, finding cigarillo packs with colors and containing a flavor descriptor were rated more positively for taste and smell. Health warnings didn’t fully mitigate the draw of the packaging.

Cigarillo packaging can influence product perception, study finds - Read More…

Scientists evaluate strategy to treat aggressive breast cancer once it's spread to the brain

Scientists evaluate strategy to treat aggressive breast cancer once it's spread to the brain

UNC Lineberger's Carey Anders, MD, and Amanda Van Swearingen, PhD, senior research specialist at UNC Lineberger, presented preclinical findings at the American Association for Cancer Research Annual Meeting 2018 about a potential promising strategy for triple negative breast cancer brain metastases. They studied the PARP inhibitor, niraparib, in three models of triple negative breast cancer with alteration and loss-of-function changes in the BRCA1 gene.

Scientists evaluate strategy to treat aggressive breast cancer once it's spread to the brain - Read More…

For aggressive breast cancer in the brain, researchers clarify immune response

For aggressive breast cancer in the brain, researchers clarify immune response

In a preliminary study presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers led by UNC Lineberger's Benjamin Vincent, MD, and Carey Anders, MD, revealed findings for what kind of immune response the body is staging against triple negative breast cancer that has spread to the brain. They hope they can use these findings to improve patient responses to drugs that work by unleashing the immune system against cancer.

For aggressive breast cancer in the brain, researchers clarify immune response - Read More…

UNC Lineberger faculty present at leading national cancer research meeting

UNC Lineberger faculty present at leading national cancer research meeting

UNC Lineberger clinicians and scientists shared their research findings at the American Association for Cancer Research's annual meeting in Chicago, April 14-18. The meeting draws tens of thousands cancer experts from around the world to learn about the latest developments in cancer research.

UNC Lineberger faculty present at leading national cancer research meeting - Read More…

Strategies identified to reverse obesity’s lingering, pro-cancer effects

Strategies identified to reverse obesity’s lingering, pro-cancer effects

In preliminary findings presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers from the lab of UNC Lineberger's Stephen Hursting, PhD, reported on a number of studies examining possible ways to reverse obesity-linked biological changes.

Strategies identified to reverse obesity’s lingering, pro-cancer effects - Read More…

To starve pancreatic tumors, researchers seek to block ‘self-eating,’ other fuel sources

To starve pancreatic tumors, researchers seek to block ‘self-eating,’ other fuel sources

UNC Lineberger researchers led by Channing Der, PhD, are reporting preclinical findings for a potential two-treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual Meeting in Chicago. The findings will be presented from 8 a.m. to noon on Wednesday.

To starve pancreatic tumors, researchers seek to block ‘self-eating,’ other fuel sources - Read More…

Lisa Carey, international breast cancer expert, appointed to Susan G. Komen’s Scientific Advisory Board

Lisa Carey, international breast cancer expert, appointed to Susan G. Komen’s Scientific Advisory Board

As a member of Susan G. Komen's Scientific Advisory Board, UNC Lineberger's Lisa A. Carey, MD, will be responsible for helping guide Komen’s $956 million research program – second only to the U.S. government in funding of breast cancer research.

Lisa Carey, international breast cancer expert, appointed to Susan G. Komen’s Scientific Advisory Board - Read More…

Dayton inducted into American Institute for Medical Engineering College of Fellows

Dayton inducted into American Institute for Medical Engineering College of Fellows

UNC Lineberger's Paul A. Dayton, PhD, was recognized for his contributions to biomedical engineering in the areas of contrast-enhanced ultrasound imaging and ultrasound-targeted therapeutics.

Dayton inducted into American Institute for Medical Engineering College of Fellows - Read More…

Payments to doctors linked to prescription practices for two cancer types

Payments to doctors linked to prescription practices for two cancer types

Compared to physicians who didn’t receive any payments, those who received payments for meals and lodging from a drug manufacturer had higher odds of prescribing that company’s particular drug for certain cancer, reported Aaron Mitchell, MD, and colleagues in JAMA Internal Medicine.

Payments to doctors linked to prescription practices for two cancer types - Read More…

Carolina students create lasting bonds with pediatric patients

Carolina students create lasting bonds with pediatric patients

UNC-Chapel Hill students volunteer at the N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center’s clinical home, to offer friendship and support to pediatric hematology and oncology patients and their families.

Carolina students create lasting bonds with pediatric patients - Read More…

Classification for cancers revealed based on immune response

Classification for cancers revealed based on immune response

In the journal Immunity, researchers co-led by UNC Lineberger's Benjamin Vincent, MD, reported their results of the analysis of immune responses in approximately 10,000 tumor samples. They revealed a new method for categorizing cancers based on their findings about the characteristics of the immune “microenvironment,” which they discovered using different types of genomic analysis, including RNA-sequencing.

Classification for cancers revealed based on immune response - Read More…

Genomic analysis of thousands of tumors supports new cancer classification

Genomic analysis of thousands of tumors supports new cancer classification

A study by researchers from The Cancer Genome Atlas (TCGA) Network, and led by UNC Lineberger's Katherine Hoadley, PhD, supports an additional classification for human tumors.

Genomic analysis of thousands of tumors supports new cancer classification - Read More…

UNC Lineberger researchers help map the cancer genome, generate key insights

UNC Lineberger researchers help map the cancer genome, generate key insights

UNC Lineberger researchers led two major projects to mark the finale of The Cancer Genome Atlas project, which was backed by the National Cancer Institute and National Human Genome Research Institute.

UNC Lineberger researchers help map the cancer genome, generate key insights - Read More…

UNC Lineberger symposium draws luminaries in field of DNA repair

UNC Lineberger symposium draws luminaries in field of DNA repair

The 42nd Annual UNC Lineberger Scientific Symposium included presentations on the science of DNA damage and repair in normal cells and cancer, and efforts to identify ways improve the immune response to DNA damage when it occurs in tumors.

UNC Lineberger symposium draws luminaries in field of DNA repair - Read More…

Some e-cigarette ingredients are surprisingly more toxic than others

Some e-cigarette ingredients are surprisingly more toxic than others

Scientists led by UNC Lineberger's Robert Tarran, PhD, created a new screening technique to deduce the different toxicity levels of the more than 7,700 types of e-liquid flavors available to consumers.

Some e-cigarette ingredients are surprisingly more toxic than others - Read More…

UNC Lineberger symposium to focus on abnormal genetics, DNA repair in cancer

UNC Lineberger symposium to focus on abnormal genetics, DNA repair in cancer

UNC Lineberger’s symposia have tracked advances in the understanding and treatment of cancer since 1977, just two years after the National Cancer Institute formally recognized UNC Lineberger as a cancer center.

UNC Lineberger symposium to focus on abnormal genetics, DNA repair in cancer - Read More…

Improved capture of cancer cells could aid in disease tracking

Improved capture of cancer cells could aid in disease tracking

In the journal Clinical Cancer Research, UNC Lineberger's Andrew Wang, MD and colleagues reported that by forcing cancer cells to slow down and developing stronger molecular traps for them, they could identify large numbers of the cells in cancer patients undergoing radiation therapy.

Improved capture of cancer cells could aid in disease tracking - Read More…

Triangle Business Journal recognizes Martin with 2018 Women in Business Award

Triangle Business Journal recognizes Martin with 2018 Women in Business Award

UNC Lineberger's Barbara Alvarez Martin, MPH, honored for her work to bring together public and business organizations to improve the health and well-being of Triangle-area communities and residents.

Triangle Business Journal recognizes Martin with 2018 Women in Business Award - Read More…

To halt breast cancer’s spread, scientists block amino acid found in asparagus

To halt breast cancer’s spread, scientists block amino acid found in asparagus

UNC Lineberger researchers, including Charles M. Perou, PhD, and Lisa A. Carey, MD, were part of a preclinical study that found blocking the production of asparagine with a drug called L-asparaginase in mice with aggressive triple negative breast tumors, and putting them on a low-asparagine diet, reduced the breast tumor’s ability to spread.

To halt breast cancer’s spread, scientists block amino acid found in asparagus - Read More…

UNC Lineberger researchers identify genetic ‘seeds’ of metastatic breast cancer

UNC Lineberger researchers identify genetic ‘seeds’ of metastatic breast cancer

In the Journal of Clinical Investigation, UNC Lineberger researchers Lisa A. Carey, MD, Charles M. Perou, PhD, and Carey Anders, MD, Marni Siegel and colleagues published their analysis of the genetic differences they discovered in patients’ primary breast cancers and their metastatic cancers.

UNC Lineberger researchers identify genetic ‘seeds’ of metastatic breast cancer - Read More…

Prognostic tool could identify high-risk breast cancer patients

Prognostic tool could identify high-risk breast cancer patients

In the journal Cell Chemical Biology, researchers led by UNC Lineberger's Xian Chen, PhD, report on potential prognostic tool that could be used to identify high-risk patients within particular subtypes of breast cancer.

Prognostic tool could identify high-risk breast cancer patients - Read More…

Researchers identify molecular target for brain cancer, develop immunotherapy approach to attack it

Researchers identify molecular target for brain cancer, develop immunotherapy approach to attack it

A team led by UNC Lineberger's Gianpietro Dotti, MD, has engineered immune cells to hunt glioblastoma, the most lethal primary brain tumor. They presented their findings in Science Translational Medicine.

Researchers identify molecular target for brain cancer, develop immunotherapy approach to attack it - Read More…

Mayer advising NCI on cancer survivorship issues and research

Mayer advising NCI on cancer survivorship issues and research

UNC Lineberger's Deborah K. Mayer, PhD, RN, AOCN, FAAN, will continue to work at UNC-Chapel Hill while providing counsel to the National Cancer Institute’s Division of Cancer Control and Population Sciences on issues related to cancer survivorship.

Mayer advising NCI on cancer survivorship issues and research - Read More…

Sellers named 2018 Health Care Hero

Sellers named 2018 Health Care Hero

Triangle Business Journal recognizes Jean Sellers, RN, MSN, for her work to improve access to high quality cancer care in North Carolina.

Sellers named 2018 Health Care Hero - Read More…

New therapeutic gel shows promise against cancerous tumors

New therapeutic gel shows promise against cancerous tumors

The lab of Zhen Gu, PhD, in the joint UNC-NC State biomedical engineering department developed a biodegradable hydrogel scaffold system to release chemotherapeutic and immunotherapeutic drugs at the tumor site.

New therapeutic gel shows promise against cancerous tumors - Read More…

Phase I clinical trial shows some promise for investigational drug for melanoma

Phase I clinical trial shows some promise for investigational drug for melanoma

Three of 15 patients with BRAF-mutant melanoma had partial responses to an investigational compound in an early-stage study led by UNC Lineberger's Stergios Moschos, MD.

Phase I clinical trial shows some promise for investigational drug for melanoma - Read More…

American Society of Clinical Oncology's annual report features UNC Lineberger research

American Society of Clinical Oncology's annual report features UNC Lineberger research

Research findings by Ethan Basch, MD, MSc, and Ronald C. Chen, MD, MPH, were cited as being among the most impactful advances and policy developments in cancer in 2017.

American Society of Clinical Oncology's annual report features UNC Lineberger research - Read More…

Patient research advocates help scientists-in-training communicate findings more effectively

Patient research advocates help scientists-in-training communicate findings more effectively

UNC Lineberger’s Patient Research Advocacy Group will help scientists and trainees to consider the patient perspective when conducting and presenting their research.

Patient research advocates help scientists-in-training communicate findings more effectively - Read More…

Researchers define structure, function of enzyme key to blood cancers

Researchers define structure, function of enzyme key to blood cancers

In the journal Nature, UNC Lineberger's Greg Wang, PhD, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.

Researchers define structure, function of enzyme key to blood cancers - Read More…

HIV exports viral protein in cellular packages

HIV exports viral protein in cellular packages

A study from the lab of UNC Lineberger's Dirk Dittmer, PhD, found that HIV sends out a protein called Nef in cellular packages called exosomes.

HIV exports viral protein in cellular packages - Read More…

Gene therapy researchers find viral barcode to cross the blood-brain barrier

Gene therapy researchers find viral barcode to cross the blood-brain barrier

Scientists led by UNC Lineberger's Aravind Asokan, PhD, reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.

Gene therapy researchers find viral barcode to cross the blood-brain barrier - Read More…

Milowsky to co-chair national bladder cancer task force

Milowsky to co-chair national bladder cancer task force

Matthew Milowsky, MD, will help oversee a panel that provides insight on bladder cancer research and priorities proposed by the National Cancer Institute’s Genitourinary Cancers Steering Committee.

Milowsky to co-chair national bladder cancer task force - Read More…

UNC Lineberger researcher launches startup to improve radiation treatment in developing world

UNC Lineberger researcher launches startup to improve radiation treatment in developing world

UNC Lineberger's Sha Chang, PhD, was named to the latest class of KickStart Venture Services' Commercialization Award winners. She plans to use the funding to launch test site implementation of the startup's solution for improving radiation treatment precision for cancer.

UNC Lineberger researcher launches startup to improve radiation treatment in developing world - Read More…

Health indicators for newborns of breast cancer survivors may vary by cancer type

Health indicators for newborns of breast cancer survivors may vary by cancer type

In a study published in the International Journal of Cancer, researchers led by UNC Lineberger's Hazel Nichols, PhD, analyzed health indicators for children born to young breast cancer survivors in North Carolina.

Health indicators for newborns of breast cancer survivors may vary by cancer type - Read More…

Adolescents not susceptible to cigarette smoking are using e-cigarettes

Adolescents not susceptible to cigarette smoking are using e-cigarettes

In a study led by UNC Lineberger's Adam Goldstein, MD, researchers found that efforts are needed to help youth remain nicotine free – especially those adolescents who aren’t otherwise susceptible to smoking cigarettes.

Adolescents not susceptible to cigarette smoking are using e-cigarettes - Read More…

UNC Lineberger to use Colon Cancer Coalition grant to promote screening in Eastern North Carolina

UNC Lineberger to use Colon Cancer Coalition grant to promote screening in Eastern North Carolina

UNC Lineberger’s Carolina Cancer Screening Initiative is working in partnership with the Roanoke Chowan Community Health Center in Ahoskie, North Carolina, to improve the colorectal cancer screening rates in a part of the state that has been significantly challenged by this disease.

UNC Lineberger to use Colon Cancer Coalition grant to promote screening in Eastern North Carolina - Read More…

Yeh and Strahl named Smithies Investigators

Yeh and Strahl named Smithies Investigators

The UNC School of Medicine selected professors from the departments of surgery, and biochemistry and biophysics for the annual award in honor of Oliver Smithies, UNC’s first Nobel Prize winner.

Yeh and Strahl named Smithies Investigators - Read More…

UNC Lineberger awards $1.1M in developmental research grants

UNC Lineberger awards $1.1M in developmental research grants

Eleven projects -- four basic science, four clinical/translational science and three population science -- were selected from a pool of 60 applicants from a broad range of disciplines.

UNC Lineberger awards $1.1M in developmental research grants - Read More…

UNC Lineberger researchers honored for highly cited scientific publications

UNC Lineberger researchers honored for highly cited scientific publications

Clarivate Analytics’ annual Highly Cited Researchers list included seven UNC Lineberger faculty members, whose scientific publications were among the top 1 percent most referenced from their field.

UNC Lineberger researchers honored for highly cited scientific publications - Read More…

Cells lacking nuclei struggle to move in 3-D environments

Cells lacking nuclei struggle to move in 3-D environments

A study led by UNC Lineberger's Keith Burridge, PhD, and published in the Journal of Cell Biology, examined the role of the physical structure of the nucleus in cell movement through different surfaces.

Cells lacking nuclei struggle to move in 3-D environments - Read More…

'Corona Cares' brews up a record year of support for UNC Lineberger

'Corona Cares' brews up a record year of support for UNC Lineberger

The program has contributed more than $1.24 million since its inception to UNC Lineberger’s Comprehensive Cancer Support Program.

'Corona Cares' brews up a record year of support for UNC Lineberger - Read More…

Narrowing the gap toward precision medicine for pancreatic cancer

Narrowing the gap toward precision medicine for pancreatic cancer

To improve treatment and our understanding of one of the deadliest cancers in the United States, UNC Lineberger's Jen Jen Yeh, MD, was involved in two studies that take different approaches to precision medicine for pancreatic cancer.

Narrowing the gap toward precision medicine for pancreatic cancer - Read More…

From a novel support group to a book, learning from seven widowed fathers

From a novel support group to a book, learning from seven widowed fathers

UNC Lineberger’s Donald Rosenstein, MD, and Justin Yopp, PhD, have published a compelling book, “The Group: Seven Widowed Fathers Reimagine Life,” that recounts the lessons a group of widowed fathers learned in responding to loss and grief.

From a novel support group to a book, learning from seven widowed fathers - Read More…

UNC Lineberger in 2017: A year of scientific and clinical advances

UNC Lineberger in 2017: A year of scientific and clinical advances

A look back at notable events and achievements at UNC Lineberger Comprehensive Cancer Center last year.

UNC Lineberger in 2017: A year of scientific and clinical advances - Read More…

Cozzo wins 2017 Marci Kramish Campbell Dissertation Award

Cozzo wins 2017 Marci Kramish Campbell Dissertation Award

Marci Campbell, PhD, was a national leader in cancer prevention and control, disparities and survivorship research, a faculty leader at UNC-Chapel Hill and a program leader at UNC Lineberger. The award established in her honor recognizes excellence in dissertation research focused on cancer and the population sciences.

Cozzo wins 2017 Marci Kramish Campbell Dissertation Award - Read More…

UNC Lineberger researchers to develop comics, app to educate about childhood cancer in Malawi

UNC Lineberger researchers to develop comics, app to educate about childhood cancer in Malawi

A grant from the Burkitt Lymphoma Fund for Africa will help UNC Lineberger researchers develop educational materials to improve communication between patients and providers – all with the goal of helping patients stay in care throughout their treatment.

UNC Lineberger researchers to develop comics, app to educate about childhood cancer in Malawi - Read More…

Cancer survivor brings joy to pediatric oncology patients

Cancer survivor brings joy to pediatric oncology patients

For years, Eileen Sparks enjoyed making doll clothes for her granddaughter and family friends, and after her own battle with cancer, she found a new way to share her talent with some very deserving young patients at the N.C. Cancer Hospital.

Cancer survivor brings joy to pediatric oncology patients - Read More…

Gopal delivers winter commencement address

Gopal delivers winter commencement address

UNC Lineberger's Satish Gopal, MD, MPH, delivered UNC-Chapel Hill's Winter Commencement address.

Gopal delivers winter commencement address - Read More…

Studies presented at SABCS seek to understand racial disparities for breast cancer

Studies presented at SABCS seek to understand racial disparities for breast cancer

UNC Lineberger clinicians and researchers presented scientific findings at the 2017 San Antonio Breast Cancer Symposium, the world's largest breast cancer research meeting.

Studies presented at SABCS seek to understand racial disparities for breast cancer - Read More…

Young cancer patient gets trip of a lifetime, joins SWAT team for the day

Young cancer patient gets trip of a lifetime, joins SWAT team for the day

Make-A-Wish of Eastern North Carolina and the Durham Police Department SWAT team helped reveal a once-in-a-lifetime surprise for Noah Marmito and his family at the N.C. Cancer Hospital on Tuesday, Dec. 19.

Young cancer patient gets trip of a lifetime, joins SWAT team for the day - Read More…

UNC Lineberger researchers present blood cancer treatment advances at ASH

UNC Lineberger researchers present blood cancer treatment advances at ASH

The 59th American Society of Hematology Annual Meeting, held Dec. 9-12, drew approximately 25,000 people from around the globe to Atlanta to hear UNC Lineberger researchers and others present the latest advances into the causes and treatment of blood cancers and disorders.

UNC Lineberger researchers present blood cancer treatment advances at ASH - Read More…

Chen awarded $11.9 million grant to study radiation treatments for prostate cancer

Chen awarded $11.9 million grant to study radiation treatments for prostate cancer

Ronald C. Chen, MD, MPH, will use the PCORI grant to conduct national comparative study of intensity-modulated radiation therapy and proton beam for prostate cancer.

Chen awarded $11.9 million grant to study radiation treatments for prostate cancer - Read More…

Skin cancer treatment selfie goes viral, has public health lessons

Skin cancer treatment selfie goes viral, has public health lessons

Researchers led by UNC Lineberger's Seth Noar, PhD, analyzed the impact of one viral social media post in generating awareness about skin cancer.

Skin cancer treatment selfie goes viral, has public health lessons - Read More…

Study shows survival benefits for seeing an NCI specialist for multiple myeloma

Study shows survival benefits for seeing an NCI specialist for multiple myeloma

William Wood, MD, and colleagues presented preliminary findings at the American Society of Hematology Annual Meeting that found multiple myeloma patients seen at an NCI comprehensive cancer center within one year of diagnosis had better survival, even after controlling for various factors.

Study shows survival benefits for seeing an NCI specialist for multiple myeloma - Read More…

Immunotherapy could be beneficial for relapsed acute myeloid leukemia

Immunotherapy could be beneficial for relapsed acute myeloid leukemia

Researchers led by UNC Lineberger's Joshua Zeidner, MD, presented preliminary results from an ongoing phase II trial of the checkpoint inhibitor pembrolizumab and chemotherapy for relapsed or refractory acute myeloid leukemia at the 59th American Society of Hematology Annual Meeting in Atlanta.

Immunotherapy could be beneficial for relapsed acute myeloid leukemia - Read More…

Using software, researchers predict tumor markers that could be immune targets

Using software, researchers predict tumor markers that could be immune targets

UNC Lineberger researchers led by Benjamin Vincent, MD, reported preliminary findings at the 59th American Society for Hematology Annual Meeting in Atlanta that are an early step in the overall plan to use the software’s predictions to develop immune-based therapies for leukemia.

Using software, researchers predict tumor markers that could be immune targets - Read More…

Biological factors don't completely explain racial disparities for ‘good prognosis’ breast cancer

Biological factors don't completely explain racial disparities for ‘good prognosis’ breast cancer

The biological features of patients’ tumors partially explained a racial disparity for women with hormone receptor-positive, HER2-negative breast cancer, but UNC Lineberger researchers led by Katherine Reeder-Hayes, MD, MBA, MSc, said it didn’t explain it completely. The preliminary findings were reported at the 2017 San Antonio Breast Cancer Symposium.

Biological factors don't completely explain racial disparities for ‘good prognosis’ breast cancer - Read More…

Forbes names Dees as a top breast cancer expert in the U.S.

Forbes names Dees as a top breast cancer expert in the U.S.

UNC Lineberger’s Claire Dees, MD, is one of the country’s top 27 breast oncologists, according to Forbes magazine.

Forbes names Dees as a top breast cancer expert in the U.S. - Read More…

NCI grant to help more cancer patients become tobacco-free

NCI grant to help more cancer patients become tobacco-free

A grant from the National Cancer Institute will help expand tobacco cessation programs for cancer patients at the N.C. Cancer Hospital.

NCI grant to help more cancer patients become tobacco-free - Read More…

North Carolina wide receiver honored for devotion to patients

North Carolina wide receiver honored for devotion to patients

University of North Carolina at Chapel Hill wide receiver Austin Proehl was lauded for his dedication to patients on the Bone Marrow Transplant Unit.

North Carolina wide receiver honored for devotion to patients - Read More…

Leukemia & Lymphoma Society awards grant to Savoldo for immunotherapy research

Leukemia & Lymphoma Society awards grant to Savoldo for immunotherapy research

The Leukemia & Lymphoma Society grant will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."

Leukemia & Lymphoma Society awards grant to Savoldo for immunotherapy research - Read More…

Pairing cancer genomics with cognitive computing highlights potential therapeutic options

Pairing cancer genomics with cognitive computing highlights potential therapeutic options

Study findings suggest that cognitive computing could help physicians to stay abreast of an ever-expanding body of scientific literature as well as highlight potential cancer therapeutic options.

Pairing cancer genomics with cognitive computing highlights potential therapeutic options - Read More…

Damania named American Association for the Advancement of Science fellow

Damania named American Association for the Advancement of Science fellow

UNC Lineberger's Blossom Damania, PhD, was one of three professors from UNC-Chapel Hill, and among 396 new fellows in total, who were recognized by their peers for their distinguished efforts to advance science and its applications.

Damania named American Association for the Advancement of Science fellow - Read More…

'Hats for Hope' founder gives back in memory of her daughter

'Hats for Hope' founder gives back in memory of her daughter

Elizabeth Stewart of Pender County and her supporters delivered more than 3,300 hats, blankets, socks, scarves and other items for cancer patients at the N.C. Cancer Hospital, UNC Lineberger's clinical home, on Nov. 9 as part of Hats for Hope, the Annual Charli’ Ramsey Hat Drive.

'Hats for Hope' founder gives back in memory of her daughter - Read More…

Study: E-cigarette online vendors triple, concerns raised about marketing, pricing and delivery

Study: E-cigarette online vendors triple, concerns raised about marketing, pricing and delivery

Two studies led by UNC Lineberger's Rebecca Williams, MHS, PhD, reveal trends in the marketing practices, pricing, delivery methods and other features of online e-cigarette vendors.

Study: E-cigarette online vendors triple, concerns raised about marketing, pricing and delivery - Read More…

Cancer drug parity laws lower costs for many, but not everyone

Cancer drug parity laws lower costs for many, but not everyone

In an analysis of the impact of parity laws published in JAMA Oncology, UNC Lineberger researchers led by Stacie Dusetzina, PhD, and collaborators from Harvard Medical School report modest improvements in costs for many patients. However, patients who were already paying the most for their medications, saw their monthly costs go up.

Cancer drug parity laws lower costs for many, but not everyone - Read More…

Stover presented with inaugural Michael S. O'Malley Alumni Award

Stover presented with inaugural Michael S. O'Malley Alumni Award

The honor recognizes UNC Gillings School of Global Public Health graduates for outstanding population-based cancer research publications.

Stover presented with inaugural Michael S. O'Malley Alumni Award - Read More…

Satish Gopal to deliver UNC-Chapel Hill Winter Commencement address

Satish Gopal to deliver UNC-Chapel Hill Winter Commencement address

Gopal, MD, MPH, a member of UNC Lineberger, works to prevent, diagnose, and treat cancer in Malawi, Africa.

Satish Gopal to deliver UNC-Chapel Hill Winter Commencement address - Read More…

Details uncovered in development of immune cell implicated in cancer, autoimmune diseases

Details uncovered in development of immune cell implicated in cancer, autoimmune diseases

UNC Lineberger’s Yisong Wan, PhD, and colleagues report in Nature new details about the development of Th17, a type of immune cell that is believed to play a complex role in cancer, and is also implicated in autoimmune diseases.

Details uncovered in development of immune cell implicated in cancer, autoimmune diseases - Read More…

Sexual function concerns not always reflected in prostate cancer treatment choices

Sexual function concerns not always reflected in prostate cancer treatment choices

A study led by UNC Lineberger's Ronald C. Chen, MD, MPH, found that preference for preserving sexual function was not strongly reflected in the treatment choices of men with low-risk prostate cancer.

Sexual function concerns not always reflected in prostate cancer treatment choices - Read More…

Timing could matter to how responsive cancer cells are to treatment, study suggests

Timing could matter to how responsive cancer cells are to treatment, study suggests

In a new study published in Cell Systems, UNC Lineberger's Jeremy Purvis, PhD, and colleagues report that the timing of when DNA damage occurs within these different checkpoints matters to a cell’s fate.

Timing could matter to how responsive cancer cells are to treatment, study suggests - Read More…

Using new knowledge about cell division, researchers look to improve chemotherapy effects

Using new knowledge about cell division, researchers look to improve chemotherapy effects

A study led by UNC Lineberger member Michael J. Emanuele, PhD, was featured on the cover of The Journal of Biological Chemistry. The researchers uncovered new details about a protein called NUSAP1 during chromosome segregation, and offered a possible way to sensitize cancer cells to a particular type of chemotherapy.

Using new knowledge about cell division, researchers look to improve chemotherapy effects - Read More…

Sharpless sworn in as National Cancer Institute director

Sharpless sworn in as National Cancer Institute director

Norman E. Sharpless, MD, who served as director of the UNC Lineberger Comprehensive Cancer Center from January 2014-June 2017, was formally sworn in as director of the National Cancer Institute on Oct. 17.

Sharpless sworn in as National Cancer Institute director - Read More…

Scientific retreat highlights faculty research, cancer center initiatives

Scientific retreat highlights faculty research, cancer center initiatives

During the annual UNC Lineberger Scientific Retreat on Oct. 10, Interim Director Shelton "Shelley" Earp shared his assessment of current and future research initiatives. Eight center researchers gave presentations on their work, and a poster competition highlighted the work of graduate students and post-doctoral fellows.

Scientific retreat highlights faculty research, cancer center initiatives - Read More…

UNC Lineberger postdoctoral fellows receive Pagano Award

UNC Lineberger postdoctoral fellows receive Pagano Award

This year’s recipients of The Joseph S. Pagano Award are Rajarshi Choudhury, PhD, Rui Lu, PhD, and George Souroullas, PhD.

UNC Lineberger postdoctoral fellows receive Pagano Award - Read More…

Wheeler awarded UNC’s Hettleman Prize for Artistic and Scholarly Achievement

Wheeler awarded UNC’s Hettleman Prize for Artistic and Scholarly Achievement

University of North Carolina recognizes Stephanie Wheeler, PhD, for her research using mathematical modeling and systems thinking to address complex health services and policy questions.

Wheeler awarded UNC’s Hettleman Prize for Artistic and Scholarly Achievement - Read More…

Honoring excellence in cancer care and services

Honoring excellence in cancer care and services

Friends, family members and colleagues recently gathered at the North Carolina Cancer Hospital to honor Paula Landman, RN, MSN, CPON, Tammy Triglianos, ANP, ANCOP, Glenda Blackwood and Craig Rifkin, RT, the 2017 Oncology Excellence Awards recipients.

Honoring excellence in cancer care and services - Read More…

Scientists lay the foundation for better research into anti-RAS therapies

Scientists lay the foundation for better research into anti-RAS therapies

In a paper published in the journal Science Signaling, Channing Der, PhD, and colleagues were able to screen chemical reagents to help researchers in the search for RAS-targeted therapies.

Scientists lay the foundation for better research into anti-RAS therapies - Read More…

Pagano honored for 42 years of leadership for UNC Lineberger’s postdoctoral trainees

Pagano honored for 42 years of leadership for UNC Lineberger’s postdoctoral trainees

Joseph Pagano, MD, director emeritus of UNC Lineberger, has led UNC Lineberger's postdoctoral training program since its inception.

Pagano honored for 42 years of leadership for UNC Lineberger’s postdoctoral trainees - Read More…

Delays for melanoma surgeries linked to insurance type

Delays for melanoma surgeries linked to insurance type

Ade Adamson, MD, MPP, and Nancy E. Thomas, MD, PhD, report in JAMA Dermatology that surgical treatment delays – defined as surgery that occurred more than six weeks after diagnosis – were common. Medicaid patients were 36 percent more likely than private insurance patients to experience delays.

Delays for melanoma surgeries linked to insurance type - Read More…

Blood test for HPV may help predict risk in cancer patients

Blood test for HPV may help predict risk in cancer patients

Preliminary findings from a study led by UNC Lineberger's Bhisham Chera, MD, and Gaorav Gupta, MD, PhD, suggest a genetic test for HPV16 in the blood could be useful to help assess risk for patients, and could help identify patients suitable for lower treatment doses. The findings were presented at this year’s American Society of Radiation Oncology Annual Meeting, held Sept. 24-27 in San Diego.

Blood test for HPV may help predict risk in cancer patients - Read More…

Roy Williams' Fast Break Against Cancer tops $2.4M

Roy Williams' Fast Break Against Cancer tops $2.4M

North Carolina men's basketball coach Roy Williams hosted his 13th annual Fast Break Against Cancer breakfast and auction to support cancer research at the UNC Lineberger Comprehensive Cancer Center.

Roy Williams' Fast Break Against Cancer tops $2.4M - Read More…

 UNC Lineberger gears up for Victory Ride to Cure Cancer

UNC Lineberger gears up for Victory Ride to Cure Cancer

The V Foundation for Cancer Research hosted a launch party for its Victory Ride to Cure Cancer, a newly created charity cycling event that will take place in the Triangle next May and will benefit Duke Cancer Institute, UNC Lineberger Comprehensive Cancer Center, and the Wake Forest Baptist Health Comprehensive Cancer Center, as well as breakthrough cancer research nationwide.

UNC Lineberger gears up for Victory Ride to Cure Cancer - Read More…

Radiation oncology researchers present at ASTRO

Radiation oncology researchers present at ASTRO

Nearly 30 UNC Lineberger studies were featured at the American Society for Radiation Oncology’s 2017 Annual Meeting was held in San Diego Sept. 24-27.

Radiation oncology researchers present at ASTRO - Read More…

To improve melanoma treatment, researchers look to block deletion of ‘self-reactive’ immune cells

To improve melanoma treatment, researchers look to block deletion of ‘self-reactive’ immune cells

UNC Lineberger researchers led by Maureen Su, MD, report on a potential new way to fight melanoma by blocking one of the immune system’s checks and balances.

To improve melanoma treatment, researchers look to block deletion of ‘self-reactive’ immune cells - Read More…

Details of how cells 'release the brakes' on division revealed

Details of how cells 'release the brakes' on division revealed

In a new study led by UNC Lineberger member Michael J. Emanuele, PhD, researchers discovered details of one way that cells release their brakes to allow replication and division to proceed.

Details of how cells 'release the brakes' on division revealed - Read More…

Warnings of tobacco addiction considered believable

Warnings of tobacco addiction considered believable

In the journal Nicotine & Tobacco Research, UNC Lineberger researcher Adam Goldstein, MD, MPH, and Allison Lazard, PhD, compared how believable adults and adolescents found different warnings on addiction and tobacco.

Warnings of tobacco addiction considered believable - Read More…

Smitherman and Alexander join pediatric hematology-oncology program

Smitherman and Alexander join pediatric hematology-oncology program

UNC Lineberger Comprehensive Cancer Center is proud to announce that Andrew Smitherman, MD, MSc, and Thomas Alexander, MD, MPH, have been appointed to the Division of Pediatric Hematology-Oncology.

Smitherman and Alexander join pediatric hematology-oncology program - Read More…

DeSimone named recipient of 22nd Heinz Award

DeSimone named recipient of 22nd Heinz Award

UNC Lineberger's Joseph DeSimone, PhD, has been named the recipient of the 22nd Heinz Award in the Technology, the Economy and Employment category.

DeSimone named recipient of 22nd Heinz Award - Read More…

Savings less than expected for generic oral chemotherapy

Savings less than expected for generic oral chemotherapy

A study led by UNC Lineberger's Stacie Dusetzina, PhD, compared the cost of the generic and brand-name version of capecitabine, which was one of the first high-priced chemotherapy pills to come off patent in the United States. Their findings offer a glimpse into what could be happening with generic competition in this specialty drug market.

Savings less than expected for generic oral chemotherapy - Read More…

Research collaboration launched in South Africa to study Kaposi sarcoma

Research collaboration launched in South Africa to study Kaposi sarcoma

UNC Lineberger's Dirk Dittmer, PhD, has launched a collaboration with researchers in South Africa to investigate the biology of Kaposi sarcoma, a cancer caused by a herpes virus and associated with infection with HIV.

Research collaboration launched in South Africa to study Kaposi sarcoma - Read More…

Innovative cancer data resource expands, gains a new name

Innovative cancer data resource expands, gains a new name

Academics and policymakers are using the Cancer Information & Population Health Resource, or CIPHR, to knit together data from multiple public and private sources to examine a wide range of complex issues tied to improving cancer outcomes in North Carolina.

Innovative cancer data resource expands, gains a new name - Read More…

Zeny’s Garden offers patients peace of mind and body

Zeny’s Garden offers patients peace of mind and body

The newly established community garden at SECU Family House honors the legacy of the late Zeny Datiles, who was a dietician at UNC Hospitals, and provides a healthy respite -- and fresh vegetables -- for patients and their families.

Zeny’s Garden offers patients peace of mind and body - Read More…

Striving to save more children with cancer in Malawi

Striving to save more children with cancer in Malawi

Kate Westmoreland, MD, a fellow in the UNC Department of Pediatric Hematology Oncology has a bold goal - increase the survival rate of Burkitt lymphoma in Malawi from 30 percent to more than 60 percent. Learn how this Winston-Salem native is working to improve pediatric oncology in sub-Saharan Africa.

Striving to save more children with cancer in Malawi - Read More…

From the Ground up: The State of Cancer Care in Malawi

From the Ground up: The State of Cancer Care in Malawi

UNC Lineberger's Satish Gopal, MD, head of UNC’s cancer care efforts at UNC-Project Malawi, will welcome collaborators from across the region for the Malawi Cancer Care Symposium on Aug. 28 and 29.

From the Ground up: The State of Cancer Care in Malawi - Read More…

Study sheds light on why some breast cancers have limited response to immunotherapy

Study sheds light on why some breast cancers have limited response to immunotherapy

Jonathan Serody, MD, Benjamin Vincent, MD, and a team of UNC Lineberger investigators published findings in the Journal of Clinical Investigation that may explain why drugs designed to unleash the immune system against cancer were ineffective in treating a type of triple negative breast cancer. They determined “claudin-low” tumors were releasing a chemical signal to attract regulatory T-cells, which prevented the immune system from rejecting the cancer.

Study sheds light on why some breast cancers have limited response to immunotherapy - Read More…

51 UNC Lineberger physicians recognized as 'Best Doctors'

51 UNC Lineberger physicians recognized as 'Best Doctors'

Best Doctors in America® List is the product of a national survey of physicians, who are asked which physicians they would see if they needed treatment for specific medical issues.

51 UNC Lineberger physicians recognized as 'Best Doctors' - Read More…

Gillings names Ribisl chair of health behavior department

Gillings names Ribisl chair of health behavior department

UNC Gillings School of Global Public Health has appointed UNC Lineberger's Kurt Ribisl, PhD, as chair of its health behavior department.

Gillings names Ribisl chair of health behavior department - Read More…

 Researchers find genetic precursors of leukemia in cancer patients

Researchers find genetic precursors of leukemia in cancer patients

A study led by UNC Lineberger's Catherine Coombs, MD, revealed new risk factors for “clonal hematopoiesis,” a medical phenomenon in which genetic mutations are found in the blood cells of patients who do not have an existing blood cancer.

Researchers find genetic precursors of leukemia in cancer patients - Read More…

Researchers look to improve detection of skin cancer lacking pigment melanin

Researchers look to improve detection of skin cancer lacking pigment melanin

UNC Lineberger researchers led by Nancy Thomas, MD, PhD, have identified key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin.

Researchers look to improve detection of skin cancer lacking pigment melanin - Read More…

Rosenstein elected head of national psychosocial oncology society

Rosenstein elected head of national psychosocial oncology society

UNC Lineberger's Donald Rosenstein, MD, director of the UNC Comprehensive Cancer Support Program, was elected to lead the American Psychosocial Oncology Society.

Rosenstein elected head of national psychosocial oncology society - Read More…

Aggressive breast cancers may contribute to racial survival disparities

Aggressive breast cancers may contribute to racial survival disparities

In the Journal of the National Cancer Institute, UNC Lineberger researchers led by Melissa Troester, PhD, published results of an analysis of approximately 1,000 invasive breast tumors. The study confirmed that young black women are more likely to have “triple negative,” or “basal-like,” breast cancers, a subtype that does not express any of the receptors for targeted biologic therapies. The study also identified variation by race within a clinical breast cancer type that has the greatest mortality disparity.

Aggressive breast cancers may contribute to racial survival disparities - Read More…

UNC Lineberger program focused on improving screening rates, reducing cancer deaths

UNC Lineberger program focused on improving screening rates, reducing cancer deaths

The Carolina Cancer Screening Initiative, led by Daniel S. Reuland, MD, MPH, brings together UNC Lineberger’s clinicians and public health researchers with community partners to implement evidence-based cancer screening programs to reduce cancer burden among North Carolinians.

UNC Lineberger program focused on improving screening rates, reducing cancer deaths - Read More…

Home test for HPV may be lifesaving for women who do not receive regular cervical cancer screenings

Home test for HPV may be lifesaving for women who do not receive regular cervical cancer screenings

A study led by UNC Lineberger's Jennifer Smith, PhD, professor of epidemiology at the UNC Gillings School of Global Public Health, found that among a group of 429 women who did not undergo routine cervical cancer screenings, two-thirds used and returned an in-home self-test, and 15 percent tested positive for human papillomavirus.

Home test for HPV may be lifesaving for women who do not receive regular cervical cancer screenings - Read More…

Clinical trials framework proposed to bring cancer treatments to sub-Saharan Africa

Clinical trials framework proposed to bring cancer treatments to sub-Saharan Africa

In the journal PLOS Medicine, Satish Gopal, MD, MPH, cancer program director for UNC-Project Malawi, outlined a framework to design studies and bring cancer therapies to sub-Saharan Africa in the absence of clinical trial data specific to the region’s population and health care infrastructure.

Clinical trials framework proposed to bring cancer treatments to sub-Saharan Africa - Read More…

Duke Endowment grant to help UNC Lineberger roll out lay patient navigation program across N.C.

Duke Endowment grant to help UNC Lineberger roll out lay patient navigation program across N.C.

Thomas C. Shea, MD, associate director for Outreach Programs at UNC Cancer Network, and Jean Sellers, RN, MSN, clinical administrative director at UNC Cancer Network, will use the $600,000 grant to help implement the UNC Lay Patient Navigation Program in 10 hospitals and cancer care facilities that collectively cover a wide geographic region of the state.

Duke Endowment grant to help UNC Lineberger roll out lay patient navigation program across N.C. - Read More…

Clark, Freeman selected for 2017 Pope Clinical Fellows Awards

Clark, Freeman selected for 2017 Pope Clinical Fellows Awards

Leslie Clark, MD, and Ashley Freeman, MD, were honored with the 2017 Pope Clinical Fellows Awards for demonstrating excellence in cancer research and in clinical oncology practice.

Clark, Freeman selected for 2017 Pope Clinical Fellows Awards - Read More…

UNC Lineberger-Sylvia Lauterborn Oncology Nursing Fellows honored with celebration

UNC Lineberger-Sylvia Lauterborn Oncology Nursing Fellows honored with celebration

Faculty and staff from UNC Lineberger and the UNC School of Nursing gathered together on Monday, June 26, to honor students Jackie Balliot, Madison Morgan and Kaitlyn Pickert upon completion of their oncology nursing fellowship program.

UNC Lineberger-Sylvia Lauterborn Oncology Nursing Fellows honored with celebration - Read More…

Using ‘sticky’ nanoparticles, researchers develop new strategy to boost body’s cancer defenses

Using ‘sticky’ nanoparticles, researchers develop new strategy to boost body’s cancer defenses

In the journal Nature Nanotechnology, UNC Lineberger researchers led by Andrew Wang, MD, report on strides made in the development of a strategy to improve the immune system's detection of cancer proteins by using “sticky” nanoparticles.

Using ‘sticky’ nanoparticles, researchers develop new strategy to boost body’s cancer defenses - Read More…

Online program improves weight loss after childbirth

Online program improves weight loss after childbirth

A study published in the Journal of the American Medical Association, and co-authored by UNC Lineberger member Deborah Tate, PhD, communicated the results of an internet-based weight loss program in low-income women in the year after giving birth. By helping new mothers return to their pre-pregnancy weights, they hope to lower their risk for obesity and chronic diseases, such as cancer.

Online program improves weight loss after childbirth - Read More…

Muss named a ‘Giant of Cancer Care’

Muss named a ‘Giant of Cancer Care’

Hyman B. Muss, MD, was honored at a ceremony in Chicago for his contributions that have advanced the fields of supportive, palliative and geriatric cancer care.

Muss named a ‘Giant of Cancer Care’ - Read More…

Researchers show how a cancer gene protects genome organization

Researchers show how a cancer gene protects genome organization

A study led by Brian Strahl, PhD, and colleagues has uncovered a crucial function of a yeast enzyme Set2, whose well-conserved human counterpart is often mutated in cancers, especially kidney cancer.

Researchers show how a cancer gene protects genome organization - Read More…

UNC Lineberger research featured at ASCO Annual Meeting

UNC Lineberger research featured at ASCO Annual Meeting

Research presented by UNC Lineberger members was featured in plenary and other major sessions of the meeting this year, and was picked up by multiple media outlets.

UNC Lineberger research featured at ASCO Annual Meeting - Read More…

UNC Cancer Survivors Day brings community together for day of celebration, education

UNC Cancer Survivors Day brings community together for day of celebration, education

Cancer survivors, their care providers and UNC faculty and staff were at the William and Ida Friday Center for Continuing Education on Saturday, June 10, in a show of community and support, and to share information on issues facing survivors.

UNC Cancer Survivors Day brings community together for day of celebration, education - Read More…

Researchers strive to improve cancer care for older patients

Researchers strive to improve cancer care for older patients

At the 2017 American Society of Clinical Oncology Annual Meeting in Chicago, UNC Lineberger researchers led by Hyman B. Muss, MD, presented preliminary findings from several studies focused on older adults with cancer.

Researchers strive to improve cancer care for older patients - Read More…

New models of kidney cancer may drive immunotherapy research

New models of kidney cancer may drive immunotherapy research

UNC Lineberger member William Y. Kim, MD, and his colleagues report in the journal Nature Communications they have created laboratory models of both papillary and clear cell renal cell carcinoma that faithfully mimic the genetic changes seen in tumors of patients with these cancers.

New models of kidney cancer may drive immunotherapy research - Read More…

Promising results found for treatment of melanoma in the brain

Promising results found for treatment of melanoma in the brain

At the American Society of Clinical Oncology Annual Meeting 2017 in Chicago, researchers presented promising data for two different investigational drug regimens used to treat melanoma that has spread to the brain, a common and deadly complication of this cancer.

Promising results found for treatment of melanoma in the brain - Read More…

Black, white men view impacts of prostate cancer treatment differently, study finds

Black, white men view impacts of prostate cancer treatment differently, study finds

UNC Lineberger researchers led by Ronald C. Chen, MD, MPH, surveyed 1,171 men diagnosed with prostate cancer in North Carolina, finding that while both white and black men were concerned about curing their cancer and the quality-of-life impacts of treatment, more black men considered other social and personal factors -- such as recovery time and cost -- to be very important in their treatment decision-making.

Black, white men view impacts of prostate cancer treatment differently, study finds - Read More…

Cancer patients who systematically reported their symptoms lived longer

Cancer patients who systematically reported their symptoms lived longer

A study presented by Ethan Basch, MD, MSc, at the American Society of Clinical Oncology is the first to find a survival benefit for patient reported outcomes.

Cancer patients who systematically reported their symptoms lived longer - Read More…

With ‘new life’ after transplant, cancer survivor renews marriage vows

With ‘new life’ after transplant, cancer survivor renews marriage vows

Recognizing that her husband now had a chance for a new, healthier life thanks to a stem cell transplant, Jackie Hannah secretly arranged for a ceremony for her husband David and her to renew their marriage vows. While he was in the Bone Marrow Transplant Unit in March, just after the transplant, and still dressed in his pajamas, David married Jackie again with hospital staff in attendance.

With ‘new life’ after transplant, cancer survivor renews marriage vows - Read More…

Payments linked to higher odds of doctors prescribing certain cancer drugs

Payments linked to higher odds of doctors prescribing certain cancer drugs

In preliminary findings presented at the American Society of Clinical Oncology Annual Meeting 2017, researchers show that when physicians had to choose between multiple, on-patent drugs for metastatic kidney cancer and chronic myeloid leukemia, they were more likely to prescribe drugs from companies they had received general payments from.

Payments linked to higher odds of doctors prescribing certain cancer drugs - Read More…

Symposium outlines career options for postdoctoral fellows

Symposium outlines career options for postdoctoral fellows

UNC Lineberger invited postdoctoral fellows to hear from three scientists who have chosen different science career paths after earning their doctoral degree.

Symposium outlines career options for postdoctoral fellows - Read More…

Researchers continue to seek strategy for starving brain tumors

Researchers continue to seek strategy for starving brain tumors

In the journal Cancer Research, UNC Lineberger researchers led by member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify a suitable therapeutic target within the sugar metabolism pathway, and provide clues to a scientific mystery surrounding the confounding way that some cancer cells get energy from sugar.

Researchers continue to seek strategy for starving brain tumors - Read More…

UNC Lineberger physicians, researchers to share study findings, clinical expertise at ASCO Annual Meeting 2017

UNC Lineberger physicians, researchers to share study findings, clinical expertise at ASCO Annual Meeting 2017

UNC Lineberger physicians and researchers will present their study findings at the 2017 American Society of Clinical Oncology Annual Meeting, which is expected to draw thousands of people to Chicago this weekend.

UNC Lineberger physicians, researchers to share study findings, clinical expertise at ASCO Annual Meeting 2017 - Read More…

UNC-Chapel Hill spinout company generates more than $108M in stock offering

UNC-Chapel Hill spinout company generates more than $108M in stock offering

Founded with support from KickStart Venture Services, a UNC-Chapel Hill program that works to turn University research into new companies, G1 Therapeutics is developing novel therapeutics based on discoveries at UNC Lineberger Comprehensive Cancer Center.

UNC-Chapel Hill spinout company generates more than $108M in stock offering - Read More…

UNC Lineberger’s symposium facilitates new ideas, collaborations

UNC Lineberger’s symposium facilitates new ideas, collaborations

Fifteen speakers shared their latest research at UNC Lineberger’s 41st Annual Scientific Symposium, which was held at the William & Ida Friday Center for Continuing Education on the theme of “Developmental Signal Transduction Pathways in Cancer.”

UNC Lineberger’s symposium facilitates new ideas, collaborations - Read More…

Superior Court Judge Carl Fox to speak at UNC Cancer Survivors Day on June 10

Superior Court Judge Carl Fox to speak at UNC Cancer Survivors Day on June 10

The annual day celebrating cancer survivors and their caregivers will include interactive educational talks and discussions and is free and open to the public.

Superior Court Judge Carl Fox to speak at UNC Cancer Survivors Day on June 10 - Read More…

UNC Lineberger marks Clinical Trials Day

UNC Lineberger marks Clinical Trials Day

Clinical Trials Day honors clinical research professionals by recognizing their contributions to public health and medical progress. UNC Lineberger faculty and staff celebrated the day by sharing photos on social media.

UNC Lineberger marks Clinical Trials Day - Read More…

UNC Lineberger’s 41st Annual Scientific Symposium to focus on signal transduction in cancer

UNC Lineberger’s 41st Annual Scientific Symposium to focus on signal transduction in cancer

UNC Lineberger's 41st Annual Scientific Symposium will focus on "Developmental Signal Transduction Pathways in Cancer.” The symposium will be held May 22-23 at the William and Ida Friday Center for Continuing Education in Chapel Hill.

UNC Lineberger’s 41st Annual Scientific Symposium to focus on signal transduction in cancer - Read More…

Strategy significantly boosts colorectal screening

Strategy significantly boosts colorectal screening

UNC Lineberger researchers led by Dan Reuland, MD, MPH, report in JAMA Internal Medicine that providing one-on-one support and customized tools for decision-making increased screening rates for patients at two community health centers in North Carolina and New Mexico.

Strategy significantly boosts colorectal screening - Read More…

In ovarian cancer, researchers uncover new drivers of cell division

In ovarian cancer, researchers uncover new drivers of cell division

UNC Lineberger's Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.

In ovarian cancer, researchers uncover new drivers of cell division - Read More…

UNC Lineberger celebrates Nurses Week

UNC Lineberger celebrates Nurses Week

UNC Lineberger marked National Nurses Week by highlighting three N.C. Cancer Hospital nurses who take such incredible care of our patients.

UNC Lineberger celebrates Nurses Week - Read More…

UNC Lineberger team helps make Pancreatic Cancer Purple Stride 5K a success

UNC Lineberger team helps make Pancreatic Cancer Purple Stride 5K a success

UNC's Running RAScals participated in this year’s PanCAN #PurpleStride run on Saturday, April 29. The team, organized by Kirsten Bryant, PhD, consisted of 76 members and raised over $13,000 to support the Pancreatic Cancer Action Network.

UNC Lineberger team helps make Pancreatic Cancer Purple Stride 5K a success - Read More…

Finding genetic variations common in black women could improve breast cancer outcomes, reduce recurrence

Finding genetic variations common in black women could improve breast cancer outcomes, reduce recurrence

UNC Lineberger researchers Charles M. Perou, PhD, Katherine Hoadley, PhD, and Melissa Troester, PhD, co-authored a large, multi-institutional study designed to understand a gap in mortality for black and white women with breast cancer by beginning to unravel the germline genetic variations and tumor biological differences. This is the first “ancestry-based comprehensive analysis of multiple platforms of genomic and proteomic data of its kind,” the authors note.

Finding genetic variations common in black women could improve breast cancer outcomes, reduce recurrence - Read More…

Robert McGinty named 2017 Searle Scholar

Robert McGinty named 2017 Searle Scholar

UNC Lineberger's Robert McGinty, MD, PhD, has been selected as a 2017 Searle Scholar. He is the first Searle Scholar named at the University of North Carolina in the past 10 years.

Robert McGinty named 2017 Searle Scholar - Read More…

Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy

Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy

In a pair of preclinical studies published in the journal Neuro-Oncology, UNC Lineberger's C. Ryan Miller, MD, PhD, and the Phoenix-based Translational Genomics Research Institute report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type.

Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy - Read More…

Study confirms link between alcohol consumption, breast cancer risk in black women

Study confirms link between alcohol consumption, breast cancer risk in black women

In findings published in the journal Cancer, Epidemiology, Biomarkers & Prevention, UNC Lineberger Comprehensive Cancer Center researchers confirmed the link between alcohol consumption and breast cancer risk in a study in black women. The association has been seen in other studies drawn from majority white populations.

Study confirms link between alcohol consumption, breast cancer risk in black women - Read More…

Images of health risks make indoor tanning messages more effective

Images of health risks make indoor tanning messages more effective

UNC Lineberger's Seth Noar, PhD, and colleagues report in a new study that anti-tanning bed messages with images showing longer-term health effects, such as skin cancer or wrinkles, produced greater negative emotional reactions and higher ratings of effectiveness in a survey of female college students than text-only messages.

Images of health risks make indoor tanning messages more effective - Read More…

UNC Lineberger receives $4 million gift to support promising new cancer treatment

UNC Lineberger receives $4 million gift to support promising new cancer treatment

Seeking to help in the development of treatments for metastatic cancer, Alice Lehman of Charlotte has donated $4 million to further the work of UNC Lineberger's new cellular immunotherapy research program.

UNC Lineberger receives $4 million gift to support promising new cancer treatment - Read More…

Cancer burden for aging U.S. HIV population projected to shift

Cancer burden for aging U.S. HIV population projected to shift

UNC-Chapel Hill researcher Jessica Y. Islam, in collaboration with the National Cancer Institute and Centers for Disease Control and Prevention, reported findings Wednesday at the American Association for Cancer Research Annual Meeting that the total number of HIV-positive cancer patients in the United States is projected to decrease through 2030. She and her collaborators also projected that there would be a decrease in cancers linked to the advanced stage of HIV infection -- AIDS.

Cancer burden for aging U.S. HIV population projected to shift - Read More…

UNC Lineberger researchers speak at governor's mansion for launch of Metastatic Breast Cancer Awareness Month

UNC Lineberger researchers speak at governor's mansion for launch of Metastatic Breast Cancer Awareness Month

N.C. Gov. Roy Cooper declared April as Metastatic Breast Cancer Awareness Month in North Carolina to bring attention to this second-leading cause of cancer death among women. UNC Lineberger researchers joined First Lady Kristin Cooper at the Executive Mansion on Monday at a luncheon hosted by the North Carolina Oncology Navigator Association.

UNC Lineberger researchers speak at governor's mansion for launch of Metastatic Breast Cancer Awareness Month - Read More…

Nanoparticle treatment could improve immunotherapy against cancer

Nanoparticle treatment could improve immunotherapy against cancer

UNC Lineberger's Andrew Wang, MD, presented preliminary findings at the American Association for Cancer Research Annual Meeting 2017 from a preclinical study into the use of nanoparticles to improve the efficacy of immunotherapy drugs known as checkpoint inhibitors.

Nanoparticle treatment could improve immunotherapy against cancer - Read More…

Aggressive breast cancer grows faster in obese environment

Aggressive breast cancer grows faster in obese environment

In an abstract presented at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger's Liza Makowski, PhD, reported her and her colleagues' preliminary findings that breast cancer cells grew larger when they were transplanted into fatty, obese tissue.

Aggressive breast cancer grows faster in obese environment - Read More…

Broad support exists for larger warnings on cigarette packs

Broad support exists for larger warnings on cigarette packs

A study led by UNC Lineberger researcher Adam Goldstein, MD, MPH, and Sarah Kowitt, MPH, found broad support, even among smokers, for increasing the size of health warnings on cigarette packs.

Broad support exists for larger warnings on cigarette packs - Read More…

UNC Lineberger researchers to present at AACR Annual Meeting

UNC Lineberger researchers to present at AACR Annual Meeting

The 2017 American Association for Cancer Research Annual Meeting in Washington, D.C., April 1-5, is expected to draw more than 20,000 scientists, clinicians, advocates, and others, including UNC Lineberger faculty, to discuss advances in the field of cancer science.

UNC Lineberger researchers to present at AACR Annual Meeting - Read More…

Preterm births more common in mothers who are cancer survivors

Preterm births more common in mothers who are cancer survivors

UNC Lineberger's Hazel Nichols, PhD, Chelsea Anderson, MPH, and their colleagues report that women diagnosed and treated for cancer during their childbearing years more commonly gave birth prematurely, and to babies whose weights were below normal. Cancer survivors also had a slightly higher rate of cesarean section deliveries.

Preterm births more common in mothers who are cancer survivors - Read More…

UNC Lineberger expands cancer survivors’ program to more N.C. locations

UNC Lineberger expands cancer survivors’ program to more N.C. locations

Through the N.C. Cancer Survivorship Provider Action Network (NC-CSPAN), cancer survivors and their loved ones can participate in a free, four-week educational program on nutrition, exercise, coping with stress and medical care. The program seeks to engage survivors to smooth the transition from active treatment.

UNC Lineberger expands cancer survivors’ program to more N.C. locations - Read More…

New insights into side effects can help prostate cancer patients choose treatments

New insights into side effects can help prostate cancer patients choose treatments

In the Journal of the American Medical Association, a study led by UNC Lineberger member Ronald C. Chen, MD, MPH, examines quality-of-life outcomes for modern treatment choices most patients will face, including active surveillance, radical prostatectomy, external beam radiation treatment, and brachytherapy.

New insights into side effects can help prostate cancer patients choose treatments - Read More…

Society for Gynecologic Oncology annual meeting features UNC Lineberger data, honors two researchers

Society for Gynecologic Oncology annual meeting features UNC Lineberger data, honors two researchers

Emma L. Barber, MD, received an award for the “Best Clinical Poster Abstract” presented at the 2016 annual meeting and Leslie Clark, MD, was awarded the Laurel Rice Young Investigator Prize.

Society for Gynecologic Oncology annual meeting features UNC Lineberger data, honors two researchers - Read More…

ASPO honors Ribisl with Joseph W. Cullen Memorial Award

ASPO honors Ribisl with Joseph W. Cullen Memorial Award

Kurt Ribisl, PhD, recognized for his research evaluating and improving the reach of population-level efforts to reduce tobacco use with a particular emphasis on policy and information technology.

ASPO honors Ribisl with Joseph W. Cullen Memorial Award - Read More…

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases

In a study published in journal Nature Immunology, researchers led by UNC Lineberger member Jenny P.Y. Ting, PhD, described how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the balance of bacteria living in the gut. Beneficial bacteria may be the key to reversing inflammation in the absence of this key regulator.

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases - Read More…

Earp, Ting recognized for career achievements in cancer research

Earp, Ting recognized for career achievements in cancer research

UNC Lineberger's H. Shelton Earp, MD, director of UNC Cancer Care and the Lineberger Professor of Cancer Research, and Jenny P.Y. Ting, PhD, the William Rand Kenan Professor of Genetics, have been honored with the Hyman L. Battle Distinguished Cancer Research Award.

Earp, Ting recognized for career achievements in cancer research - Read More…

UNC Lineberger launches innovative cellular immunotherapy program

UNC Lineberger launches innovative cellular immunotherapy program

UNC Lineberger, with its U.S. FDA-approved Good Manufacturing Practices, or “clean,” facility, is one of only a select academic centers in the United States with the capability to genetically modify patient immune cells for clinical use. This makes it possible for people who live in the Southeastern U.S. to stay closer to home to undergo cellular immunotherapy treatment.

UNC Lineberger launches innovative cellular immunotherapy program - Read More…

Spring deadline is March 15 for cancer research grant proposals

Spring deadline is March 15 for cancer research grant proposals

There are two categories of awards offered this spring for the UNC Lineberger Developmental Funding Award: Pilot Awards of up to $50,000 for one-year projects involving one principal investigator, and Stimulus Awards of up to $100,000 per year for one or two years for projects that enhance our scientific understanding of cancer basic mechanisms or clinical and public health practice.

Spring deadline is March 15 for cancer research grant proposals - Read More…

Measuring patients' muscles to predict chemotherapy side effects

Measuring patients' muscles to predict chemotherapy side effects

UNC Lineberger researchers Hy Muss, MD, Shlomit Strulov Shachar, MD, and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for side effects that could require hospitalization.

Measuring patients' muscles to predict chemotherapy side effects - Read More…

Researchers awarded grant to study strategy to improve immunotherapy response

Researchers awarded grant to study strategy to improve immunotherapy response

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

Researchers awarded grant to study strategy to improve immunotherapy response - Read More…

Patients and their records agree on medical history for most maladies

Patients and their records agree on medical history for most maladies

A study led by UNC Lineberger researcher Ronald Chen, MD, found that a group of prostate cancer patients reliably reported their own medical histories when their responses were compared to their medical records.

Patients and their records agree on medical history for most maladies - Read More…

Higher risk of death linked to eating more smoked or grilled meat before breast cancer

Higher risk of death linked to eating more smoked or grilled meat before breast cancer

UNC Lineberger's Marilie D. Gammon, PhD, and Humberto Parada, PhD, report in JNCI: The Journal of the National Cancer Institute that breast cancer patients who ate barbecued, grilled and smoked meats at higher annual amounts in the decade before their diagnosis had a greater risk of death from any cause.

Higher risk of death linked to eating more smoked or grilled meat before breast cancer - Read More…

Revolutionary approach for treating glioblastoma works with human cells

Revolutionary approach for treating glioblastoma works with human cells

UNC Lineberger's Shawn Hingtgen, PhD, and colleagues, in laboratory studies, have converted human skin cells into stem cells that can hunt down and kill human brain cancer, an important step to moving the approach closer to a clinical trial.

Revolutionary approach for treating glioblastoma works with human cells - Read More…

With gift of scarves, women address cancer's impact on image

With gift of scarves, women address cancer's impact on image

Thanks to the donation of handmade scarves from community groups, UNC Lineberger’s Patient and Family Resource Center staff are helping women to counter some of the side effects of cancer treatments. In addition to receiving a beautiful scarf, the women were taught different ways to wear it.

With gift of scarves, women address cancer's impact on image - Read More…

U.S. cancer death rate declines, but work is needed to address local disparities

U.S. cancer death rate declines, but work is needed to address local disparities

UNC Lineberger researchers Ethan Basch, MD, MSc, and Stephanie Wheeler, PhD, MPH, called for tailored, local-level cancer prevention, screening and treatment efforts to address regional disparities in cancer mortality rates in an editorial published in the Journal of the American Medical Association.

U.S. cancer death rate declines, but work is needed to address local disparities - Read More…

Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

In the journal Cancer Discovery, UNC Lineberger's Gary Johnson, PhD, and colleagues published findings on how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved kinase inhibitor. They also demonstrated in a laboratory model a potential treatment approach that could prevent the onset of resistance.

Researchers unlock mechanism of drug resistance in aggressive breast cancer - Read More…

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse

A team of researchers, including UNC Lineberger's Norman E. Sharpless, MD, has shown that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse.

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse - Read More…

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer

Backed by a three-year, more than $1.8 million grant from the National Cancer Institute, UNC Lineberger researchers Ryan Miller, MD, PhD, and Gary Johnson, PhD, plan to develop better cancer models to identify patterns of drug resistance in glioblastoma.

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer - Read More…

 Cost, technology issues are barriers to real-time cancer patient symptom reporting

Cost, technology issues are barriers to real-time cancer patient symptom reporting

In a perspective published in the New England Journal of Medicine, UNC Lineberger member Ethan Basch, MD, MSc, addressed the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.

Cost, technology issues are barriers to real-time cancer patient symptom reporting - Read More…

In memoriam: Oliver Smithies, DPhil

In memoriam: Oliver Smithies, DPhil

UNC Lineberger member and Nobel Laureate Oliver Smithies, DPhil, passed away Jan. 10. UNC Lineberger Director Norman E. Sharpless, MD, said Smithies "played a critical role in the university’s evolution into a world-leading scientific juggernaut."

In memoriam: Oliver Smithies, DPhil - Read More…

Scientists use light to control the logic networks of a cell

Scientists use light to control the logic networks of a cell

Scientists at the University of North Carolina at Chapel Hill have developed a method to control proteins inside live cells with the flick of a switch, giving researchers an unprecedented tool for pinpointing the causes of disease using the simplest of tools: light.

Scientists use light to control the logic networks of a cell - Read More…

Start-up with UNC ties secures $2.9M to develop blood test for cancer

Start-up with UNC ties secures $2.9M to develop blood test for cancer

A start-up company co-founded by UNC Lineberger researcher Andrew Wang, MD, has raised $2.9 million to commercialize a test designed to capture cancer cells circulating in the blood.

Start-up with UNC ties secures $2.9M to develop blood test for cancer - Read More…

Inside the world of cell signaling: a G-protein breakthrough

Inside the world of cell signaling: a G-protein breakthrough

Scientists led by UNC Lineberger member John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

Inside the world of cell signaling: a G-protein breakthrough - Read More…

In blood of patients treated for other cancers, researchers find genetic precursors of leukemia

In blood of patients treated for other cancers, researchers find genetic precursors of leukemia

In a study presented at the American Society of Hematology Annual Meeting in San Diego, Catherine C. Coombs, MD, MS, and colleagues reported that nearly a quarter of patients heavily treated for other cancers had mutations in their white blood cells, and that the majority of those mutations were leukemia-linked.

In blood of patients treated for other cancers, researchers find genetic precursors of leukemia - Read More…

UNC, Duke researchers unite around mission of preventing virus-induced cancers

UNC, Duke researchers unite around mission of preventing virus-induced cancers

Researchers and clinicians attended the 2016 UNC-Duke Viral Oncology & AIDS Malignancy Symposium on Dec. 14 to hear presentations and share their perspectives on the latest efforts to prevent and treat cancers linked to infectious agents.

UNC, Duke researchers unite around mission of preventing virus-induced cancers - Read More…

Cigar warning labels are not equally believable among adolescents

Cigar warning labels are not equally believable among adolescents

Less than 50 percent of surveyed teens found it ‘very believable’ that cigars are not a safe alternative to cigarettes, according to a first-of-its-kind study led by a UNC Lineberger researcher.

Cigar warning labels are not equally believable among adolescents - Read More…

Symposium addresses an age-old question about older cancer patients

Symposium addresses an age-old question about older cancer patients

The University of North Carolina Lineberger Comprehensive Cancer Center Geriatric Research Symposium, held Dec. 2, featured seven presentations and panel discussions focused on muscle mass, aging and patient function.

Symposium addresses an age-old question about older cancer patients - Read More…

UNC Lineberger researchers present findings at San Antonio Breast Cancer Symposium

UNC Lineberger researchers present findings at San Antonio Breast Cancer Symposium

UNC Lineberger breast cancer faculty members presented their research findings at the 2016 San Antonio Breast Cancer Symposium Dec. 6-10. The meeting drew more than 7,000 cancer caregivers and scientists from around the world, who attended talks and presentations on the latest developments in breast cancer care and research.

UNC Lineberger researchers present findings at San Antonio Breast Cancer Symposium - Read More…

For invasive breast cancer, researchers identify biomarkers of treatment response

For invasive breast cancer, researchers identify biomarkers of treatment response

UNC Lineberger researchers reported at the San Antonio Breast Cancer Symposium they have identified biomarkers they believe can be used as part of a larger model to predict how patients with HER2-positive operative breast cancer will respond to the targeted treatment trastuzumab, commercially known as Herceptin, and chemotherapy.

For invasive breast cancer, researchers identify biomarkers of treatment response - Read More…

Brain metastasis persists despite improved targeted treatment for HER2 breast cancer

Brain metastasis persists despite improved targeted treatment for HER2 breast cancer

At this year's San Antonio Breast Cancer Symposium, UNC Lineberger researchers and collaborators shared the outcomes of their investigation into the incidence of brain metastasis after a series of drugs were approved to treat HER2-positive metastatic breast cancer, starting with trastuzumab, also known as Herceptin, in the United States in 1998.

Brain metastasis persists despite improved targeted treatment for HER2 breast cancer - Read More…

Researchers developing model to predict if chemotherapy will work for aggressive breast cancer

Researchers developing model to predict if chemotherapy will work for aggressive breast cancer

In a study presented at the 2016 San Antonio Breast Cancer Symposium, UNC Lineberger researchers led by Katherine Hoadley, PhD, reported they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy.

Researchers developing model to predict if chemotherapy will work for aggressive breast cancer - Read More…

Genetic alterations more common in tumors of older patients with metastatic breast cancer

Genetic alterations more common in tumors of older patients with metastatic breast cancer

In preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers showed that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.

Genetic alterations more common in tumors of older patients with metastatic breast cancer - Read More…

Thomas named chair of dermatology	department

Thomas named chair of dermatology department

UNC Lineberger member Nancy Thomas, MD, PhD, has been named chair of the Department of Dermatology, effective Jan. 1.

Thomas named chair of dermatology department - Read More…

Holidays and cancer: Tips for celebrating the season with less stress

Holidays and cancer: Tips for celebrating the season with less stress

Balancing medical needs with the desire to have a “normal” holiday can be challenging when someone is experiencing health issues, but the Patient and Family Resource Center staff at the N.C. Cancer Hospital and UNC Lineberger Comprehensive Cancer Center have found that patients and their families who discuss and prioritize what traditions matter most are able to focus more on celebrating – and less on stressing over – the holidays.

Holidays and cancer: Tips for celebrating the season with less stress - Read More…

Ewend named president of UNC Physicians

Ewend named president of UNC Physicians

Matt Ewend, MD, FACS, has been named President of UNC Physicians. In this role, Ewend will oversee the physician clinical enterprise of UNC Health Care, which includes more than 2,400 physicians and 600 Advanced Practice Providers in 450 practices spanning the UNC Physicians Network, UNC Faculty Physicians, and physician practices at UNC Health Care affiliate hospitals.

Ewend named president of UNC Physicians - Read More…

UNC Lineberger physician-researchers receive Pope Clinical Fellows Awards for 2016

The $5,000 awards, supported by the John William Pope Foundation, are given annually to up to three emerging physician-researchers.

UNC Lineberger physician-researchers receive Pope Clinical Fellows Awards for 2016 - Read More…

Join the Mia Hamm Foundation in raising awareness and funds for bone marrow transplant patients

Join the Mia Hamm Foundation in raising awareness and funds for bone marrow transplant patients

Mia Hamm and the Mia Hamm Foundation are partnering with UNC Lineberger today, Tuesday, Nov. 29, to provide support for bone marrow transplant patients -- and their families -- and to help them address some of the challenges they may face while undergoing treatment.

Join the Mia Hamm Foundation in raising awareness and funds for bone marrow transplant patients - Read More…

Thanksgiving lunch brings patients, caregivers together

Thanksgiving lunch brings patients, caregivers together

Hospital staff and volunteers hosted a Thanksgiving lunch on Friday, Nov. 18, for 150 patients and their caregivers. The annual lunch, provided by UNC Hospital Catering, featured a traditional holiday meal -- replete with turkey, mashed potatoes, stuffing and cranberry sauce -- live music, and a caricature artist.

Thanksgiving lunch brings patients, caregivers together - Read More…

Kosorok elected AAAS fellow

Kosorok elected AAAS fellow

The American Association for the Advancement of Science, the world’s largest general scientific society and publisher of the journal Science, announced the election of Michael R. Kosork, PhD, as a fellow. Kosork is being honored for his distinguished contributions to biostatistics, in survival analysis, empirical processes and semiparametric models, statistical learning theory and personalized medicine, and for extraordinary administrative service.

Kosorok elected AAAS fellow - Read More…

Flavors influence appeal and use of most tobacco products, especially for youth

Flavors influence appeal and use of most tobacco products, especially for youth

UNC Lineberger researchers led by Adam Goldstein, MD, MPH, concluded in a study published in Tobacco Control that banning non-menthol flavors like fruit and candy could reduce use of most tobacco products across the globe, especially among adolescents.

Flavors influence appeal and use of most tobacco products, especially for youth - Read More…

Eighth year of 'Hats for Hope' provides support, encouragement

Eighth year of 'Hats for Hope' provides support, encouragement

Volunteers collected more than 3,300 items through word of mouth, churches, social media and other organizations in eastern North Carolina for Hats for Hope, the Annual Charli’ Ramsey Hat Drive, and delivered them to adult and pediatric patients at UNC Hospitals.

Eighth year of 'Hats for Hope' provides support, encouragement - Read More…

Lee appointed chair-elect of AACI’s Clinical Research Initiative Steering Committee

Lee appointed chair-elect of AACI’s Clinical Research Initiative Steering Committee

UNC Lineberger's Carrie Lee, MD, MPH, is chair-elect of the Association of American Cancer Institute’s Clinical Research Initiative Steering Committee, which is responsible for developing better methods to disseminate information across cancer centers, identifying and addressing clinical research challenges, and measuring progress on behalf of AACI.

Lee appointed chair-elect of AACI’s Clinical Research Initiative Steering Committee - Read More…

The dark side of ‘junk’ DNA: Repeating DNA sequences play a role in bone cancer

The dark side of ‘junk’ DNA: Repeating DNA sequences play a role in bone cancer

Ian J. Davis, MD, PhD, and colleagues published a paper in Cell Reports that found certain short, repetitive sequences of DNA play an important role in the development of Ewing sarcoma, a rare bone and soft tissue cancer that occurs most commonly in children and adolescents.

The dark side of ‘junk’ DNA: Repeating DNA sequences play a role in bone cancer - Read More…

Could targeting a gene linked to microcephaly lead to a better brain cancer treatment?

Could targeting a gene linked to microcephaly lead to a better brain cancer treatment?

UNC Lineberger researchers led by Timothy R. Gershon, MD, PhD, reported preclinical findings in the journal Development that show promise for targeting a gene linked to microcephaly in infants as a treatment for medulloblastoma.

Could targeting a gene linked to microcephaly lead to a better brain cancer treatment? - Read More…

Study raises concerns about timely follow-up to positive mammogram for the uninsured

Study raises concerns about timely follow-up to positive mammogram for the uninsured

Uninsured women under age 65 who received their mammogram at community screening clinics in North Carolina were less likely to get follow-up within a year of a positive mammogram, and had higher odds of missing a 60-day window for follow-up care, according to a study Louise Henderson, PhD, and her colleagues published in Cancer Epidemiology, Biomarkers & Prevention.

Study raises concerns about timely follow-up to positive mammogram for the uninsured - Read More…

Study finds genetic variation may protect against certain HPV-linked oral cancers

Study finds genetic variation may protect against certain HPV-linked oral cancers

Andrew Olshan, PhD, and colleagues reported in Nature Genetics that immune system-related genetic variation may provide new insight into the mechanisms of protection against human papillomavirus-associated head and neck cancer.

Study finds genetic variation may protect against certain HPV-linked oral cancers - Read More…

Oncology Excellence Awards celebrate compassion and commitment

Oncology Excellence Awards celebrate compassion and commitment

North Carolina Cancer Hospital's Tony Williams Lobby was filled with friends, family and colleagues to celebrate Deborah Ballard, RN, MSN, ANP-C, OCN, Kristi Geib, RN, MSN, CPNP, CPON, Pearl Langhorne, and Jennifer Spring, RD, CSO, LDN, who received 2016 Oncology Excellence Awards.

Oncology Excellence Awards celebrate compassion and commitment - Read More…

Fellows, doctoral students present 'first-rate' science at Postdoc-Faculty Research Day

Fellows, doctoral students present 'first-rate' science at Postdoc-Faculty Research Day

More than 120 doctoral students, postdoctoral researchers and faculty members came together Oct. 18 to learn about research advances made by UNC Lineberger’s postdocs at the annual UNC Lineberger Postdoc Faculty Research Day. The day-long event included a poster competition for doctoral students and postdoctoral fellows, and an oral presentation competition.

Fellows, doctoral students present 'first-rate' science at Postdoc-Faculty Research Day - Read More…

Pecot awarded two lung cancer research grants

Pecot awarded two lung cancer research grants

The V Foundation for Cancer Research and Lung Cancer Initiative of North Carolina, as well as the Lung Cancer Research Foundation, awarded grants to support UNC Lineberger member Chad Pecot's lung cancer research.

Pecot awarded two lung cancer research grants - Read More…

Daily self-monitoring of weight, activity helps prevent weight gain among breast cancer survivors

Daily self-monitoring of weight, activity helps prevent weight gain among breast cancer survivors

In a recent study, UNC Lineberger researchers evaluated the feasibility and efficacy of two six-month, self-regulation interventions that focused on daily self-weighing, objective monitoring and tailored feedback in an effort to prevent weight gain among African-American breast cancer survivors.

Daily self-monitoring of weight, activity helps prevent weight gain among breast cancer survivors - Read More…

Burridge, a part-time playwright, to premiere show in NYC

Burridge, a part-time playwright, to premiere show in NYC

For more than three decades, playwriting has been a hobby for UNC Lineberger researcher Keith Burridge, PhD. Burridge's play “The First Woman President” will be performed at a theater festival in New York City. The play will premiere Nov. 5 at the Midtown International Theatre Festival.

Burridge, a part-time playwright, to premiere show in NYC - Read More…

'60 Minutes' profiles how UNC Lineberger is leveraging artificial intelligence

'60 Minutes' profiles how UNC Lineberger is leveraging artificial intelligence

CBS's "60 Minutes" came to UNC Lineberger to learn how researchers are using IBM Watson to cull through and generate useful clinical insights from massive amounts of genetic data.

'60 Minutes' profiles how UNC Lineberger is leveraging artificial intelligence - Read More…

Komen recognizes Charles Perou with the Brinker Award, its top scientific honor

Komen recognizes Charles Perou with the Brinker Award, its top scientific honor

Susan G. Komen announced UNC Lineberger researcher Charles M. Perou, PhD, as the recipient of this year's Brinker Award for Scientific Distinction in Basic Science for his contributions to the understanding of breast cancer as distinct molecular subtypes that have prognostic value using cutting-edge cancer genomics tools.

Komen recognizes Charles Perou with the Brinker Award, its top scientific honor - Read More…

UNC’s Purvis earns NIH Director’s New Innovator Award

UNC’s Purvis earns NIH Director’s New Innovator Award

With a focus on stem cells, Jeremy Purvis, PhD, wants to tap the power of computer modeling to develop regenerative medicine solutions to medical conditions.

UNC’s Purvis earns NIH Director’s New Innovator Award - Read More…

Roy Williams’ Fast Break Against Cancer raises more than $200,000 for 2016 – and counting

Roy Williams’ Fast Break Against Cancer raises more than $200,000 for 2016 – and counting

North Carolina men’s basketball coach Roy Williams’ much beloved event has now raised more than $2.2 million over the years for UNC Lineberger Comprehensive Cancer Center, and the total will continue to grow, thanks to an online auction that is running through Oct. 17.

Roy Williams’ Fast Break Against Cancer raises more than $200,000 for 2016 – and counting - Read More…

High up-front costs could delay access to life-saving blood cancer drugs for Medicare patients

High up-front costs could delay access to life-saving blood cancer drugs for Medicare patients

In the study published in the Journal of Clinical Oncology, UNC Lineberger researchers report that nearly a third of a group of patients with chronic myeloid leukemia, and who have federally-funded Medicare health insurance, did not start treatment within six months of diagnosis with any of three targeted drugs that have led to dramatic improvements in survival for the disease.

High up-front costs could delay access to life-saving blood cancer drugs for Medicare patients - Read More…

Study identifies most persuasive messages for parents considering HPV vaccine

Study identifies most persuasive messages for parents considering HPV vaccine

Among parents who reported that they were disinclined to vaccinate, UNC Lineberger researchers found in a recent study that the most convincing messages about the HPV vaccine were those that focused on the parent’s role in preventing the child from getting HPV-related cancers and those that emphasized their role in whether their child becomes infected with HPV.

Study identifies most persuasive messages for parents considering HPV vaccine - Read More…

Particular HPV strain linked to improved prognosis for throat cancer

Particular HPV strain linked to improved prognosis for throat cancer

In an analysis of survival data for a population of patients with a particular type of head and neck cancer, UNC Lineberger researchers confirmed that a particular strain of HPV, a virus linked to multiple cancers, resulted in better overall survival for patients with oropharyngeal cancer than patients with other strains of the virus.

Particular HPV strain linked to improved prognosis for throat cancer - Read More…

UNC Lineberger faculty, trainees advocate for federal support for research

UNC Lineberger faculty, trainees advocate for federal support for research

American Association for Cancer Research, which is advocating for a $2 billion increase to the National Institutes of Health budget, expects more than 300 scientists, health professionals and patient advocates to be at this year’s Rally for Medical Research in Washington, D.C.

UNC Lineberger faculty, trainees advocate for federal support for research - Read More…

Hyundai Hope On Wheels aims to spur innovation in childhood cancer research

Hyundai Hope On Wheels aims to spur innovation in childhood cancer research

Barbara Savoldo, MD, PhD, will use the $250,000 Hyundai Scholar Grant to help fund her research of a new generation chimeric antigen receptor-based cell therapy for neuroblastoma.

Hyundai Hope On Wheels aims to spur innovation in childhood cancer research - Read More…

Racial gaps persist in how breast cancer survivors function, feel during treatment and after

Racial gaps persist in how breast cancer survivors function, feel during treatment and after

A UNC Lineberger study published in the journal Breast Cancer Research and Treatment drew upon surveys that assessed health-related quality of life issues for women aged 20 to 74 years who lived in North Carolina and had breast cancer. The analysis was part of the third phase of the Carolina Breast Cancer Study.

Racial gaps persist in how breast cancer survivors function, feel during treatment and after - Read More…

Scientists discover interplay of yin-yang antagonists vital for cell division

Scientists discover interplay of yin-yang antagonists vital for cell division

Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.

Scientists discover interplay of yin-yang antagonists vital for cell division - Read More…

Breast cancer researchers receive $2.5 million in Susan G. Komen grants

Breast cancer researchers receive $2.5 million in Susan G. Komen grants

Susan G. Komen has announced more than $2.5 million in grants for UNC Lineberger Comprehensive Cancer Center researchers. The organization, which funded eight grants for nearly $2.97 million to researchers in North Carolina, has a goal of reducing breast cancer deaths in the U.S. by 50 percent across the next decade.

Breast cancer researchers receive $2.5 million in Susan G. Komen grants - Read More…

Harnessing radiation to improve immunotherapy response in metastatic melanoma

Harnessing radiation to improve immunotherapy response in metastatic melanoma

Andrew Z. Wang, MD, a UNC Lineberger member and associate professor in the UNC School of Medicine Department of Radiation Oncology, received an award from the U.S. Army Medical Research Acquisition Activity to study a potential mechanism for improving immunotherapy for metastatic melanoma in the lungs.

Harnessing radiation to improve immunotherapy response in metastatic melanoma - Read More…

UNC Lineberger scientific retreat poster, speaker awards announced

UNC Lineberger scientific retreat poster, speaker awards announced

UNC Lineberger's 2016 Annual Scientific Retreat included a juried poster presentation with work presented by postdoctoral researchers, trainees and students.

UNC Lineberger scientific retreat poster, speaker awards announced - Read More…

Sharpless outlines achievements, new initiatives in 2016 State of the Cancer Center address

Sharpless outlines achievements, new initiatives in 2016 State of the Cancer Center address

UNC Lineberger Director Norman Sharpless, MD, delivered the address as part of UNC Lineberger’s 2016 Annual Scientific Retreat, held Sept. 9 at the Carolina Club.

Sharpless outlines achievements, new initiatives in 2016 State of the Cancer Center address - Read More…

UNC Lineberger spring developmental grants awarded, fall applications due Sept. 15

UNC Lineberger spring developmental grants awarded, fall applications due Sept. 15

Thirteen research teams will receive grants through the spring 2016 cycle of the UNC Lineberger Developmental Grants program. The deadline for applying for the next round of funding is 5 p.m. Thursday, Sept. 15.

UNC Lineberger spring developmental grants awarded, fall applications due Sept. 15 - Read More…

NIH Precision Medicine Initiative Cohort Research Program appoints Chung to Institutional Review Board

NIH Precision Medicine Initiative Cohort Research Program appoints Chung to Institutional Review Board

UNC Lineberger's Arlene Chung, MD, MHA, MMCi, will serve as an inaugural member of the NIH Precision Medicine Initiative Cohort Program Institutional Review Board.

NIH Precision Medicine Initiative Cohort Research Program appoints Chung to Institutional Review Board - Read More…

Blood cancer treatment may age immune cells as much as 30 years

Blood cancer treatment may age immune cells as much as 30 years

Researchers led by UNC Lineberger Director Norman Sharpless, MD, and William Wood, MD, uncovered clues that suggest that stem cell transplant is linked to a marked increase in the “molecular age” of these immune cells in a group of patients with blood cancer.

Blood cancer treatment may age immune cells as much as 30 years - Read More…

Researchers question process for reviewing coverage of ‘off label’ cancer drug use

Researchers question process for reviewing coverage of ‘off label’ cancer drug use

In a paper published online by the Journal of the American Medical Association, UNC Lineberger physician-researchers led by Ethan Basch, MD, MSc, raised concerns that there are inconsistencies between the five reference guides, or compendia, that the Centers for Medicare and Medicaid Services uses to determine which drugs it will reimburse for off-label uses in cancer care.

Researchers question process for reviewing coverage of ‘off label’ cancer drug use - Read More…

Study finds links between physicians setting cancer care guidelines and drug industry

Study finds links between physicians setting cancer care guidelines and drug industry

UNC Lineberger researchers, led by Aaron Mitchell, MD, found a high prevalence of financial relationships among authors who helped develop a leading set of cancer care guidelines in the United States in a study published in JAMA Oncology. They say the work lays the foundation for future studies of whether the payments influenced clinical practice or guideline recommendations.

Study finds links between physicians setting cancer care guidelines and drug industry - Read More…

Researchers use genetics to probe immune system’s role in fighting cancer

Researchers use genetics to probe immune system’s role in fighting cancer

Findings published in the Journal of the National Cancer Institute show that immune cells do not respond the same way to all tumor types. The study, led by UNC Lineberger researcher Benjamin Vincent, MD, could lay the foundation for the discovery of biomarkers to determine which patients might respond to certain immune-stimulating cancer treatments.

Researchers use genetics to probe immune system’s role in fighting cancer - Read More…

Majority of parents support HPV vaccination requirements for school, but only with opt-outs

Majority of parents support HPV vaccination requirements for school, but only with opt-outs

A national survey found that parents were more likely to agree that laws requiring students to be vaccinated against HPV for school entry are a “good idea” when there is an opt-out clause.

Majority of parents support HPV vaccination requirements for school, but only with opt-outs - Read More…

Sharpless elected to Association of American Cancer Institutes’ Board

Sharpless elected to Association of American Cancer Institutes’ Board

UNC Lineberger Comprehensive Cancer Center Director Norman E. Sharpless, MD, has won election to the Association of American Cancer Institutes’ Board of Directors.

Sharpless elected to Association of American Cancer Institutes’ Board - Read More…

On the hunt for genetic clues to breast cancers that spread to the brain

On the hunt for genetic clues to breast cancers that spread to the brain

UNC Lineberger researcher Carey Anders, MD, wants to understand why some breast cancers metastasize to the brain, and what drives them. She recently was awarded a three-year, $450,000 grant to study genetic features of breast cancer brain metastases to try to answer those questions.

On the hunt for genetic clues to breast cancers that spread to the brain - Read More…

Heading outside? Be sun smart

Heading outside? Be sun smart

Before heading to the beach or the pool to cool down this summer, UNC Lineberger's Puneet Jolly reminds people to be mindful of their sun exposure and offers some simple sun safety tips.

Heading outside? Be sun smart - Read More…

Graphic cigarette pack warnings linked to reductions in smoking behavior, analysis finds

Graphic cigarette pack warnings linked to reductions in smoking behavior, analysis finds

In the analysis published in the journal Social Science & Medicine, researchers led by UNC Lineberger's Seth Noar found that cigarette smokers tried to quit more and smoked less overall when countries implemented new policies replacing text warnings with graphic images on cigarette packs or strengthened pack warnings in other ways.

Graphic cigarette pack warnings linked to reductions in smoking behavior, analysis finds - Read More…

Gaps found in use of Herceptin to treat breast cancer

Gaps found in use of Herceptin to treat breast cancer

A potentially life-saving breast cancer treatment was part of the care plan for one Orange County woman, but UNC Lineberger researchers have found gaps in how the treatment is used nationwide.

Gaps found in use of Herceptin to treat breast cancer - Read More…

UNC among nation’s top-ranked cancer hospitals, first in North Carolina

UNC among nation’s top-ranked cancer hospitals, first in North Carolina

The N.C. Cancer Hospital, clinical home of UNC Lineberger Comprehensive Cancer Center, continues to climb higher in U.S. News’ Best Hospitals rankings.

UNC among nation’s top-ranked cancer hospitals, first in North Carolina - Read More…

Cancer cells continue abnormal growth by activating error-prone DNA synthesis

Cancer cells continue abnormal growth by activating error-prone DNA synthesis

UNC Lineberger researchers led by Cyrus Vaziri, PhD, describe the discovery of how a specific cellular protein present in cancer cells triggers a repair mechanism that allows them to DNA damage tolerance and abnormal growth.

Cancer cells continue abnormal growth by activating error-prone DNA synthesis - Read More…

Basch receives $5.45M grant to study patient-reported outcomes

Basch receives $5.45M grant to study patient-reported outcomes

Ethan Basch, MD, MSc, will use a five-year, $5.45 million grant from the Patient-Centered Outcomes Research Institute to support his national study on whether having cancer patients self-report their symptoms while undergoing treatment results in better care.

Basch receives $5.45M grant to study patient-reported outcomes - Read More…

Debate ‘resolved’ on radiation treatment for cancers that have spread to the brain

Debate ‘resolved’ on radiation treatment for cancers that have spread to the brain

Brain radiation prolongs life for patients with cancer, but can cause serious side effects like memory delays or verbal impairments. In an editorial published Tuesday in the Journal of the American Medical Association, UNC Lineberger researchers say a new study has resolved a debate about the optimal treatment for patients with one to three brain metastases, finding “little role” for whole brain radiation.

Debate ‘resolved’ on radiation treatment for cancers that have spread to the brain - Read More…

Insurance, distance to care can be barriers to breast reconstruction

Insurance, distance to care can be barriers to breast reconstruction

Researchers say breast reconstruction can help with self-esteem, sexuality and body image after cancer treatment. But a UNC Lineberger study led by Michelle Roughton, MD, has found that the type of insurance a woman has as well as distance to a plastic surgeon's office can be barriers to the procedure.

Insurance, distance to care can be barriers to breast reconstruction - Read More…

Silverstein finds health, hope and freedom at UNC Lineberger

Silverstein finds health, hope and freedom at UNC Lineberger

When Beth Silverstein tested positive for the BRCA1 gene mutation, she knew she had to make some tough decisions about her health. But she wasn't alone. Her faith, her family and her multi-disciplinary health care team at UNC Lineberger were with her every step of the way.

Silverstein finds health, hope and freedom at UNC Lineberger - Read More…

Snuffing out illegal online tobacco sales to minors

Snuffing out illegal online tobacco sales to minors

Rebecca Williams, MHS, PhD, has studied the online sales of cigarettes and other tobacco products for nearly two decades. Through her research, including a recent paper in Tobacco Control, she has uncovered the ways the industry has gotten around government oversight, especially as it applies to sales to minors.

Snuffing out illegal online tobacco sales to minors - Read More…

Celebrating 40 years as an NCI-designated cancer center

Celebrating 40 years as an NCI-designated cancer center

In 1975, UNC Lineberger was named a "Designated Cancer Center" by the prestigious National Cancer Institute, a title that signifies we are an organization delivering high-level cancer care to patients throughout our community, state and nation. Most NCI-Designated Cancer Centers are affiliated with university medical centers, although several are freestanding centers that engage only in cancer research.

Celebrating 40 years as an NCI-designated cancer center - Read More…

Researchers launch breast cancer screening pilot in Malawi

Researchers launch breast cancer screening pilot in Malawi

Breast cancer was not a death sentence for Malawi native Maggie Zgambo. She survived cancer despite financial and other obstacles. She believes that her life was spared for a reason: to spread awareness. Maggie was one of four women to take part in the first breast cancer screening pilot study in Malawi launched by UNC Lineberger Comprehensive Cancer Center researchers and physicians.

Researchers launch breast cancer screening pilot in Malawi - Read More…

Using radiation, researchers selectively activate cancer drug

Using radiation, researchers selectively activate cancer drug

UNC Lineberger researchers led by Andrew Wang, MD, report in the International Journal of Radiation Oncology Biology Physics results from a study of using radiation to activate a new formulation of the drug mitomycin-C in colorectal cancer models.

Using radiation, researchers selectively activate cancer drug - Read More…

UNC experts: Doctors shouldn’t routinely recommend e-cigarettes to smokers

UNC experts: Doctors shouldn’t routinely recommend e-cigarettes to smokers

UNC Lineberger researcher Adam O. Goldstein, MD, MPH, and UNC Department of Family Medicine researcher Clare Meernik, MPH, write in a commentary published in the Annals of Family Medicine that existing treatments are more effective than e-cigarettes to help people quit smoking, there are professional ethics concerns about providers who recommend them and there is no strong evidence that e-cigarettes are safe.

UNC experts: Doctors shouldn’t routinely recommend e-cigarettes to smokers - Read More…

Olshan elected president of North America’s oldest epidemiology society

Olshan elected president of North America’s oldest epidemiology society

A leading expert in the molecular epidemiology of cancers of the head and neck and evaluation of risk factors for childhood cancer, Andrew Olshan, PhD, will serve as president-elect until next July, when he becomes president of the Society for Epidemiologic Research.

Olshan elected president of North America’s oldest epidemiology society - Read More…

Finding the Next Step

Finding the Next Step

UNC Lineberger researcher Blossom Damania, PhD, has built her research career tackling difficult questions in cancer and global health research. As she begins her new role as UNC School of Medicine vice dean for research, she’s considering one more: What’s next?

Finding the Next Step - Read More…

Patient navigators look to connect health systems and communities

Patient navigators look to connect health systems and communities

The North Carolina Oncology Navigator Association’s annual meeting in Chapel Hill brought together nurses, patient navigators and community health workers to focus on building connections between health systems and communities for the patient’s benefit, said UNC Lineberger’s Jean Sellers, RN, MSN, the association’s president.

Patient navigators look to connect health systems and communities - Read More…

Removing a brain tumor makes remaining cancer more aggressive

Removing a brain tumor makes remaining cancer more aggressive

A study led by UNC Lineberger member Shawn Hingtgen, PhD, has determined that removing a glioblastoma tumor from the brain causes any cancer left behind to grow much faster than the original tumor did. The findings from the Neuro-Oncology paper illustrate the effect of surgery on the brain and tumor and the need to rethink how to treat the disease differently after the surgery.

Removing a brain tumor makes remaining cancer more aggressive - Read More…

UNC Lineberger hosts Cancer Moonshoot regional summit

UNC Lineberger hosts Cancer Moonshoot regional summit

Members from North Carolina’s three National Cancer Institute-designated comprehensive cancer centers, together with care providers, researchers, advocates and patients from the state, met in Chapel Hill to be part of a national discussion on how to speed the pace of cancer discovery and clinical advances.

UNC Lineberger hosts Cancer Moonshoot regional summit - Read More…

UNC Lineberger hosts National Cancer Moonshot regional summit

UNC Lineberger hosts National Cancer Moonshot regional summit

Members from North Carolina’s three National Cancer Institute-designated comprehensive cancer centers, together with care providers, researchers, advocates and patients from the state, met in Chapel Hill to be part of a national discussion on how to speed the pace of cancer discovery and clinical advances.

UNC Lineberger hosts National Cancer Moonshot regional summit - Read More…

Risk of death for adults with blood cancer higher in three N.C. regions

Risk of death for adults with blood cancer higher in three N.C. regions

UNC Lineberger researchers led by Dr. William A. Wood found that for patients treated in a hospital, the risk of death from acute myeloid leukemia was elevated in three regions of the state compared to a benchmark.

Risk of death for adults with blood cancer higher in three N.C. regions - Read More…

Cancer-causing virus mimics host signal to drive cell growth, protein production

Cancer-causing virus mimics host signal to drive cell growth, protein production

UNC Lineberger researcher Blossom Damania, PhD, postdoctoral researcher Aadra Bhatt, PhD, and colleagues have discovered a slick trick a virus uses to spur cancerous cell growth in its host: the virus initiates a signal that mimics one of the host cell’s own signals.

Cancer-causing virus mimics host signal to drive cell growth, protein production - Read More…

Researchers discover how faulty genetic instructions drive a deadly blood cancer in adults

Researchers discover how faulty genetic instructions drive a deadly blood cancer in adults

A study by UNC Lineberger researcher G. Greg Wang, PhD, and colleagues uncovered the genetic mechanism behind how acute myeloid leukemia cells with a specific DNA mutation stay as undifferentiated cells, rather than maturing into healthy blood cells.

Researchers discover how faulty genetic instructions drive a deadly blood cancer in adults - Read More…

Racial disparities identified in some quality-of-life-oriented care for breast cancer patients

Racial disparities identified in some quality-of-life-oriented care for breast cancer patients

A study led by UNC Lineberger researchers determined that black women with advanced breast cancer were less likely to receive supportive care medications, like antidepressants and sleep aids, than white patients. They also were less likely to enroll in hospice care, and more likely to get intensive treatment at the end of their lives.

Racial disparities identified in some quality-of-life-oriented care for breast cancer patients - Read More…

Dusetzina to present to President’s Cancer Panel on cancer drug pricing and access

Dusetzina to present to President’s Cancer Panel on cancer drug pricing and access

UNC Lineberger member Stacie Dusetzina, PhD, a researcher who investigates drug pricing and insurance policy issues, will present today to the President’s Cancer Panel, and advisory group to president.

Dusetzina to present to President’s Cancer Panel on cancer drug pricing and access - Read More…

Researchers share study findings, expertise at national cancer meeting

University of North Carolina Lineberger Comprehensive Cancer Center researchers were in Chicago June 3-7 for the American Society of Clinical Oncology (ASCO) Annual Meeting.

Researchers share study findings, expertise at national cancer meeting - Read More…

Advanced cancer patients receive aggressive care at high rates at the end of life

Advanced cancer patients receive aggressive care at high rates at the end of life

A national health claims analysis of cancer patients who were younger than age 65 and had metastatic disease revealed that nearly two-thirds were admitted to the hospital or visited the emergency room in the last 30 days of their lives. The UNC Lineberger researchers, who presented the study outcomes at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago, also found that nearly a third of patients died in the hospital.

Advanced cancer patients receive aggressive care at high rates at the end of life - Read More…

Pictures on cigarette packs, warning of smoking dangers, increased quit attempts among smokers

Pictures on cigarette packs, warning of smoking dangers, increased quit attempts among smokers

Noel T. Brewer, PhD, and his UNC Lineberger colleagues report in JAMA Internal Medicine findings from their study that demonstrated that attaching graphic warning images to cigarette packs increased smokers' attempts to quit.

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Bacteria found in female upper reproductive tract, once thought sterile

Bacteria found in female upper reproductive tract, once thought sterile

In a preliminary finding presented at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago, UNC Lineberger researchers Wendy Brewster, MD, PhD, and Temitope Keku, PhD, revealed they have found bacteria in the ovaries and fallopian tubes. Researchers also uncovered a trend toward a distinct bacterial profile in women with ovarian cancer.

Bacteria found in female upper reproductive tract, once thought sterile - Read More…

Cancer patients miss appointments, prescriptions due to inability to afford care

Cancer patients miss appointments, prescriptions due to inability to afford care

More than one-in-four cancer patients had to pay more for medical care than they could afford, according to a study led by UNC Lineberger researchers. A reported 18 percent were unable to afford their prescription medications. The findings were presented at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago.

Cancer patients miss appointments, prescriptions due to inability to afford care - Read More…

Carey to co-chair national breast cancer clinical trials group

Carey to co-chair national breast cancer clinical trials group

UNC Lineberger member Lisa A. Carey, MD, has been appointed co-chair of the Alliance for Clinical Trials in Oncology Breast Committee. The national organization is responsible for developing new trials, ensuring each project’s scientific excellence, operational efficiency and productivity, and promoting collaboration with other NCI-funded clinical trials groups.

Carey to co-chair national breast cancer clinical trials group - Read More…

In all U.S. regions, broad support for increasing legal age of tobacco sales

In all U.S. regions, broad support for increasing legal age of tobacco sales

Researchers from the University of North Carolina at Chapel Hill, including UNC Lineberger member Adam Goldstein, MD, MPH, and East Carolina University reported in the American Journal of Preventive Medicine that in all nine regions of the country, a majority of adults supported increasing the minimum legal age for tobacco product sales. They also found the most support for increasing the minimum age to 21 rather than to 20 or 19.

In all U.S. regions, broad support for increasing legal age of tobacco sales - Read More…

Sancar earns UNC Board of Governors’ highest faculty honor

Sancar earns UNC Board of Governors’ highest faculty honor

Nobel Prize winner Aziz Sancar, MD, PhD, a UNC Lineberger member and the Sarah Graham Kenan Professor of Biochemistry and Biophysics at the UNC School of Medicine was one of two distinguished professors to receive the O. Max Gardner Award, the highest faculty honor of the UNC Board of Governors.

Sancar earns UNC Board of Governors’ highest faculty honor - Read More…

UNC Lineberger researcher to study cervical cancer screening tool through Grand Challenges Explorations Grant

UNC Lineberger researcher to study cervical cancer screening tool through Grand Challenges Explorations Grant

UNC Lineberger member Jennifer S. Smith, PhD, MPH, director of the Cervical Cancer-Free Coalition at the UNC Gillings School of Global Public Health and associate professor of epidemiology, will pursue an innovative global health and development research project to determine the effectiveness of a urine-based, cervical cancer screening tool under a Grand Challenges Exploration Grant, which is funded by the Bill & Melinda Gates Foundation.

UNC Lineberger researcher to study cervical cancer screening tool through Grand Challenges Explorations Grant - Read More…

Researchers link gene expression patterns of normal tissue to breast cancer prognosis

Researchers link gene expression patterns of normal tissue to breast cancer prognosis

In the journal npj Breast Cancer, researchers led by UNC Lineberger member Melissa Troester, PhD, reported they identified a particular gene expression pattern in normal-appearing breast tissue around tumors that was linked to lower 10-year survival rates for women with estrogen receptor-positive breast cancer.

Researchers link gene expression patterns of normal tissue to breast cancer prognosis - Read More…

C.A.R.E. Behind the Chair: Scalp melanoma webinar reaches hair stylists across North Carolina

C.A.R.E. Behind the Chair: Scalp melanoma webinar reaches hair stylists across North Carolina

More than 150 hair care professionals and health care providers from across North Carolina came together virtually for a webinar to discuss the topic of scalp melanoma. This event, which was broadcast live from Chapel Hill, was hosted by UNC Lineberger Comprehensive Cancer Center and UNC Cancer Network.

C.A.R.E. Behind the Chair: Scalp melanoma webinar reaches hair stylists across North Carolina - Read More…

Damania named UNC School of Medicine’s Vice Dean for Research

Damania named UNC School of Medicine’s Vice Dean for Research

UNC Lineberger member Blossom Damania, PhD, the co-director of the UNC Lineberger Global Oncology Program and the UNC Lineberger Virology Program, has been named the new vice dean for research at the UNC School of Medicine. She will replace Terry Magnuson, PhD, who has been named the vice chancellor for research at UNC-Chapel Hill.

Damania named UNC School of Medicine’s Vice Dean for Research - Read More…

UNC Lineberger members go to Washington to highlight importance of research funding

UNC Lineberger members go to Washington to highlight importance of research funding

Chad Ellis, PhD, Ben Major, PhD, and Anne-Marie Meyer, PhD, traveled to the U.S. Capitol to meet with members of the North Carolina congressional delegation and explain the impact of National Institutes of Health and National Cancer Institute funding on the lives and well-being of people in North Carolina and the country.

UNC Lineberger members go to Washington to highlight importance of research funding - Read More…

UNC Cancer Care earns national accreditation with commendation

UNC Cancer Care earns national accreditation with commendation

UNC Hospitals' cancer program, whose flagship location is the N.C. Cancer Hospital, has earned national accreditation from the Commission on Cancer of the American College of Surgeons, with commendation in three areas: clinical research accrual, reporting of outcomes and oncology nursing care.

UNC Cancer Care earns national accreditation with commendation - Read More…

Promise of nearly a year of life on targeted drug not reality for all liver cancer patients

Promise of nearly a year of life on targeted drug not reality for all liver cancer patients

A study led by UNC Lineberger Comprehensive Cancer Center members Hanna Sanoff and Stacie Dusetzina found that the liver cancer drug sorafenib does not deliver on its promise of 11 months of longer life for some advanced liver patients, and can come with serious side effects and significant out-of-pocket costs.

Promise of nearly a year of life on targeted drug not reality for all liver cancer patients - Read More…

Leeza Park, MD: Caring for the whole person

Leeza Park, MD: Caring for the whole person

For Eliza “Leeza” Park, MD, caring for people with cancer is not just about the disease - it’s about the person.

Leeza Park, MD: Caring for the whole person - Read More…

Scientists digitally mimic evolution to create novel proteins

Scientists digitally mimic evolution to create novel proteins

Published in the journal Science, a study by UNC School of Medicine researchers offers a new route to design the 'cellular machines' needed to understand and battle diseases.

Scientists digitally mimic evolution to create novel proteins - Read More…

Saluting our oncology nurses

Saluting our oncology nurses

The week of May 6-12 is National Nurses Week. At the UNC Lineberger Comprehensive Cancer Center and the N.C. Cancer Hospital, we've got some of the best. Read this Q&A with Ashley Farmer, BSN, RN, OCN, patient services manager in the Adult Oncology Infusion Center at UNC Hospitals.

Saluting our oncology nurses - Read More…

Der lab finds promising drug to fight pancreatic cancer

Der lab finds promising drug to fight pancreatic cancer

In the lab of Channing Der, PhD, a UNC Lineberger member and a Kenan Distinguished Professor in the Department of Pharmacology, researchers believe they have found a promising strategy to target a type of pancreatic cancer that is notoriously resistant to treatment—pancreatic cancer that has a mutation in a gene called KRAS.

Der lab finds promising drug to fight pancreatic cancer - Read More…

UNC honors Earp for commitment to innovation

UNC honors Earp for commitment to innovation

Shelton Earp, MD, director of UNC Cancer Care and a UNC Lineberger Comprehensive Cancer Center member, was named Inventor of the Year by the Chancellor’s Office of Innovation and Entrepreneurship at the University of North Carolina at Chapel Hill.

UNC honors Earp for commitment to innovation - Read More…

Targeting melanoma, lymphoma: Study finds investigational compound active against cancer driven by genetic mutation

Targeting melanoma, lymphoma: Study finds investigational compound active against cancer driven by genetic mutation

Norman Sharpless, MD, and colleagues reported in Nature Medicine findings from a preclinical study that demonstrated that a potential new drug effectively targeted a genetic mutation linked to melanoma and the most common form of lymphoma.

Targeting melanoma, lymphoma: Study finds investigational compound active against cancer driven by genetic mutation - Read More…

Zeidner raises awareness for bone marrow donor needs with Superior Court Judge Fox

Zeidner raises awareness for bone marrow donor needs with Superior Court Judge Fox

Superior Court Judge Carl Fox hosted a “UNC Heroes” fundraising event for the Leukemia and Lymphoma Society on Sunday, April 24 in Carrboro, NC. Judge Fox was appointed as the first black District Attorney in North Carolina in 1984 and became Senior Superior Court Judge in 2005. He was diagnosed in 2015 with a type of blood cancer called myelodysplastic syndrome.

Zeidner raises awareness for bone marrow donor needs with Superior Court Judge Fox - Read More…

Costs for orally-administered cancer drugs skyrocket

Costs for orally-administered cancer drugs skyrocket

A study, authored by UNC Lineberger member Stacie Dusetzina, PhD, found that oral cancer drugs introduced in 2014 were, on average, six times more expensive than those introduced in the year 2000. The findings, published in JAMA Oncology, raised concerns as patients may increasingly take on the cost burden of those increases.

Costs for orally-administered cancer drugs skyrocket - Read More…

‘Moonshot to Malawi’ outlines global cancer disparities

‘Moonshot to Malawi’ outlines global cancer disparities

UNC Lineberger member Satish Gopal, MD, MPH, has called for a commitment to contribute resources and energy to control cancer in less-resourced countries where there are significant gaps in cancer awareness, prevention, diagnosis, and treatment.

‘Moonshot to Malawi’ outlines global cancer disparities - Read More…

N.C. Cancer Hospital Mammography receives $250,000 gift

N.C. Cancer Hospital Mammography receives $250,000 gift

More than 70 friends and loved ones of Dr. Minhthu Nguyen gathered at the N.C. Cancer Hospital on Friday, April 22 to celebrate her life and to participate in the dedication of the hospital’s Mammography Reception Area in her honor. Nguyen, a local dentist, passed away on September 8, 2015, following her courageous four-year battle against breast cancer.

N.C. Cancer Hospital Mammography receives $250,000 gift - Read More…

"Life is good, I'm alive and I can move!"

"Life is good, I'm alive and I can move!"

At age 47, Debra Jackson was diagnosed with stage I adrenal cancer. Dr. Jen Jen Yeh was able to surgically remove all of Debra's cancerous tumor, but was worried about her patient's overall health and ability to recover. Now, three years later, Debra has lost 175 pounds, and is living healthy, happy and cancer-free.

"Life is good, I'm alive and I can move!" - Read More…

Burridge elected to the American Academy of Arts and Sciences

Burridge elected to the American Academy of Arts and Sciences

UNC Lineberger member, UNC School of Medicine professor and basic scientist Keith Burridge has conducted seminal research on the basic building blocks of cells for four decades.

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AACR 2016: Sequencing RNA in tumors could help improve cancer care, study finds

AACR 2016: Sequencing RNA in tumors could help improve cancer care, study finds

Sequencing a tumor's RNA in addition to its DNA makes it possible to better characterize the cancer’s mutations, reported Neil Hayes, MD, MPH, at the American Association for Cancer Research’s annual meeting. This additional information, said Hayes, may help improve a cancer patient’s treatment.

AACR 2016: Sequencing RNA in tumors could help improve cancer care, study finds - Read More…

AACR 2016: Blood test could gauge treatment response for head and neck cancer patients, pilot study shows

AACR 2016: Blood test could gauge treatment response for head and neck cancer patients, pilot study shows

A potential new blood test is sensitive enough to detect changes in numbers of head and neck cancer cells circulating in the blood, a pilot study by UNC Lineberger Comprehensive Cancer Center researchers and collaborators has found. The findings from the study will be presented at the American Association for Cancer Research Annual Meeting in New Orleans on Tuesday, April 19.

AACR 2016: Blood test could gauge treatment response for head and neck cancer patients, pilot study shows - Read More…

AACR 2016: UNC researchers identify promising strategy to stop an aggressive breast cancer type once it’s spread to the brain

AACR 2016: UNC researchers identify promising strategy to stop an aggressive breast cancer type once it’s spread to the brain

UNC Lineberger Comprehensive Cancer Center researchers have identified a combination of investigational drugs that have been shown to be effective together at targeting triple negative breast cancer in the brain in preclinical studies. Their findings will be presented at the American Association for Cancer Research Annual Meeting in New Orleans, Tuesday, April 19.

AACR 2016: UNC researchers identify promising strategy to stop an aggressive breast cancer type once it’s spread to the brain - Read More…

AACR 2016: Increased saturated fat in diet linked to aggressive prostate cancer

AACR 2016: Increased saturated fat in diet linked to aggressive prostate cancer

A study by researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and other institutions found a link between higher intake of dietary saturated fat, a type of fat found commonly in foods such as fatty beef and cheese, and risk of aggressive prostate cancer. The preliminary results were presented at the American Association for Cancer Research Annual Meeting in New Orleans on Monday, April 18.

AACR 2016: Increased saturated fat in diet linked to aggressive prostate cancer - Read More…

Researchers extract cancer cells’ ‘deadly secrets’ at UNC Lineberger symposium

Researchers extract cancer cells’ ‘deadly secrets’ at UNC Lineberger symposium

More than 440 people recently attended the 40th Annnual UNC Lineberger Scientific Symposium, which featured talks on treatments and ongoing research that target the RAS-RAF-MEK-ERK and other signaling pathways in cancer.

Researchers extract cancer cells’ ‘deadly secrets’ at UNC Lineberger symposium - Read More…

Women’s adherence to breast cancer screening guidelines varies following false-positive mammogram

Women’s adherence to breast cancer screening guidelines varies following false-positive mammogram

A study led by UNC Lineberger researchers has found that for women who have had a false-positive mammogram result, their likelihood to get screened at recommended intervals depends on the timing of their last screen. Louise Henderson, PhD, will present the findings at the American Association for Cancer Research Annual Meeting in New Orleans, Monday, April 18.

Women’s adherence to breast cancer screening guidelines varies following false-positive mammogram - Read More…

New study led by UNC Lineberger researchers explains why HIV is not cleared by the immune system

New study led by UNC Lineberger researchers explains why HIV is not cleared by the immune system

Jenny Ting, Ph.D. and her colleagues report research findings in Cell Host & Microbe that further explain the role of host proteins in viral replication and the innate immune response to HIV infection.

New study led by UNC Lineberger researchers explains why HIV is not cleared by the immune system - Read More…

Older women, especially blacks, receive targeted breast cancer treatment at low rates

Older women, especially blacks, receive targeted breast cancer treatment at low rates

Katherine Reeder-Hayes, MD, MBA, and her colleagues report that women age 66 and older who have HER2-positive breast cancer were less likely than younger women to be treated with trastuzumab (Herceptin), a proven, yet expensive, drug therapy.

Older women, especially blacks, receive targeted breast cancer treatment at low rates - Read More…

Studies address link between obesity and basal-like breast cancer

Studies address link between obesity and basal-like breast cancer

Recent work from the laboratory of Liza Makowski, PhD, UNC Lineberger member and assistant professor of nutrition at the UNC Gillings School of Global Public Health, explores two possibilities for breaking the link between obesity and basal-like breast cancer.

Studies address link between obesity and basal-like breast cancer - Read More…

Bill Schaller named director of communications and marketing

Bill Schaller named director of communications and marketing

Bill Schaller has been appointed director of communications and marketing at UNC Lineberger Comprehensive Cancer Center, effective Feb. 22, 2016.

Bill Schaller named director of communications and marketing - Read More…

New faces, new roles in UNC Lineberger administration

New faces, new roles in UNC Lineberger administration

UNC Lineberger has welcomed two new members to its administrative staff, Dominique Waters and Bill Schaller, and has expanded the responsibilities of two others, David Darr and Wendy Sarratt.

New faces, new roles in UNC Lineberger administration - Read More…

40th annual scientific symposium to focus on targeted cancer treatments

40th annual scientific symposium to focus on targeted cancer treatments

UNC Lineberger's annual scientific symposium, “Molecularly Targeted Cancer Therapies from Bench to Bedside,” will be held April 11-12 at The William and Ida Friday Center for Continuing Education. Thanks to event supporters, attendance is free and the cost to for lunch is minimal at $16 per day. Registration is open until 5 p.m. on Wednesday, April 6.

40th annual scientific symposium to focus on targeted cancer treatments - Read More…

Mayer, Rimer named to Cancer 'Moonshot' Blue Ribbon Panel

Mayer, Rimer named to Cancer 'Moonshot' Blue Ribbon Panel

Two UNC Lineberger Comprehensive Cancer Center members - Drs. Deborah Mayer and Barbara Rimer - have been honored with appointments to the National Cancer Moonshot Initiative's Blue Ribbon Panel. They will join a team of cancer experts to provide advice and vision in the implementation of the national program.

Mayer, Rimer named to Cancer 'Moonshot' Blue Ribbon Panel - Read More…

Weight loss surgery beats diet at inhibiting breast cancer, study finds

Weight loss surgery beats diet at inhibiting breast cancer, study finds

Weight loss surgery was more effective than a low-fat diet at reversing the cancer-promoting effects of chronic obesity in mice, UNC Lineberger Comprehensive Cancer Center researchers report in a new study. The preliminary findings will be presented April 18 at the 2016 American Association of Cancer Research Annual Meeting in New Orleans.

Weight loss surgery beats diet at inhibiting breast cancer, study finds - Read More…

It's the amount you lose, not the diet you're on, that matters in reversing cancer-obesity link

It's the amount you lose, not the diet you're on, that matters in reversing cancer-obesity link

Researchers with UNC Lineberger examined whether weight loss via four different diets was linked to reduced tumor growth in laboratory models of breast cancer. While tumor size did not differ between obese mice and obese mice that returned to a normal weight on a low-fat diet, they did find that obese mice that lost significant amounts of weight on three calorie-restricted diets had smaller tumors.

It's the amount you lose, not the diet you're on, that matters in reversing cancer-obesity link - Read More…

Genetic differences for kidney cancer may contribute to survival disparity in African-Americans

Genetic differences for kidney cancer may contribute to survival disparity in African-Americans

A UNC Lineberger-led study has identified genetic differences in tumors of African-Americans with the most common type of kidney cancer compared with whites. The researchers, led by senior author Dr. William "Billy" Kim, say the findings could help explain lower survival rates for African-Americans with clear cell renal cell carcinoma.

Genetic differences for kidney cancer may contribute to survival disparity in African-Americans - Read More…

New compound is effective against drug-resistant leukemia, preclinical study finds

New compound is effective against drug-resistant leukemia, preclinical study finds

Researchers at UNC Lineberger and at other institutions developed a new potential treatment for acute myeloid leukemia. In the journal JCI Insight, they report that the compound MRX-2843 more than doubled the median days of survival in laboratory models with a drug-resistant form of the disease.

New compound is effective against drug-resistant leukemia, preclinical study finds - Read More…

UNC experts discover colorectal cancer biomarker, potential personalized treatment

UNC experts discover colorectal cancer biomarker, potential personalized treatment

In the journal Cell Reports, UNC Lineberger researchers reported they found markedly low levels of the protein NLRX1 in multiple laboratory models of colorectal cancer, and in samples of human tissue. Studies have shown that the protein is known to be involved in regulating immune system signals in order to prevent hyperactive inflammatory responses by the immune system, but UNC Lineberger researchers believe their finding also points to a role for the protein in preventing colorectal cancer growth. Based on their findings, they believe they’ve identified a potential treatment for colorectal cancer with low NLRX1.

UNC experts discover colorectal cancer biomarker, potential personalized treatment - Read More…

Researchers share stories of their drive to fight pancreatic cancer

Researchers share stories of their drive to fight pancreatic cancer

Kirsten Bryant, PhD, a cancer researcher and postdoctoral fellow at the UNC Lineberger Comprehensive Cancer Center, and Channing Der, PhD, a UNC Lineberger member and the Sarah Graham Kenan Professor of Pharmacology, shared personal stories of why they're driven to fight pancreatic cancer at a breakfast in Durham on Tuesday.

Researchers share stories of their drive to fight pancreatic cancer - Read More…

Using new drug screening tool, UNC researchers identify potential treatments for Ewing sarcoma

Using new drug screening tool, UNC researchers identify potential treatments for Ewing sarcoma

In a first-of-its-kind-study, researchers have discovered and applied a new screening technique capable of testing thousands of potential drug compounds to see if those compounds can reverse abnormal DNA unwinding in Ewing sarcoma, a bone and soft tissue cancer that’s most common in teens and young adults.

Using new drug screening tool, UNC researchers identify potential treatments for Ewing sarcoma - Read More…

UNC researchers make groundbreaking discovery, use skin cells to kill cancer

UNC researchers make groundbreaking discovery, use skin cells to kill cancer

A preclinical study led by a UNC Lineberger Comprehensive Cancer Center researcher found that skin cells turned cancer-killing stem cells hunt down and destroy the deadly remnants inevitably left behind when a brain tumor is surgically removed.

UNC researchers make groundbreaking discovery, use skin cells to kill cancer - Read More…