UNC researchers presenting research advances at American Society of Hematology annual meeting

Nearly two dozen University of North Carolina-Chapel Hill and UNC Lineberger Comprehensive Cancer Center faculty members and trainees will present research and participate in scientific symposia and educational sessions at the 66th American Society of Hematology (ASH) Annual Meeting in San Diego, Dec. 6-10.

ASH is the world’s largest professional society of hematologists dedicated to furthering the diagnosis, treatment and prevention of blood disorders, including cancer. Last year’s meeting attracted more than 32,000 attendees from 113 countries.

UNC Lineberger and UNC researchers presenting at the meeting include:

Friday, Dec. 6

Satellite Symposium

11 a.m. – 2 p.m. PT | San Diego Convention Center, Ballroom 20CD

Medical Crossfire®: Bridging Evidence to Practice in AML… Updates on FLT3, IDH1/2, Maintenance, Combos, and Clinical Trials

Presenter: Joshua Zeidner, MD

 

3 – 6 p.m. PT | San Diego Convention Center, Room 6A

Cases and Conversations™: The Rationale for Utilizing Non-Factor Replacement Therapies in Hemophilia Care

Presenter: Alice Ma, MD

 

Scientific Workshop

2:05 – 3:05 p.m. | San Diego Convention Center, Room 24

Interplay Between Coagulation and Malignancy

Mouse Xenograft Models of Acute Promyelocytic Leukemia and Coagulopathy

Presenter: Yohei Hisada, PhD

 

3:10 – 4:35 p.m. | San Diego Convention Center, Room 24

PAR-1 and Doxorubicin Induced Cardiotoxicity

Presenter: Steven Grover, PhD

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Saturday, Dec. 7

Oral Presentation

9:30 – 11 a.m. | San Diego Convention Center, Room 31

401 Blood Transfusion: Advancements in Transfusion Science

Moderator: Samuel Wilson, MD, MSCR

 

2 – 3:30 p.m. | San Diego Convention Center, Ballroom 20CD

213 Phase 1 Results: First-in-Human Phase 1/2 Study of the Menin-MLL Inhibitor Enzomenib (DSP-5336) in Patients with Relapsed or Refractory Acute Leukemia

Presenter: Joshua Zeidner, MD

 

4 – 5:30 p.m.  |  Manchester Grand Hyatt San Diego, Seaport Ballroom EFGH

324 Real-World Analysis of CPX-351 Induction in Acute Myeloid Leukemia-Myelodysplasia Related (AML-MR): An Updated Analysis from the Marrow Consortium

Presenter: Daniel Peters, MD

 

Career Development Lunch

11:15 a.m. – 12:15 p.m. | Manchester Grand Hyatt San Diego, Coronado Ballroom

Laboratory and Translational Hematology

Presenter: Alisa Wolberg, PhD

 

Special Interest Session

4 – 5:30 p.m. | Marriott Marquis San Diego Marina, Pacific Ballroom Salons 24-26

Building a National Multiple Myeloma Data Hub to Accelerate Research and Enhance Clinical Care

Presenter: William Wood, MD, MPH

 

Poster Presentation

5:30 – 7:30 p.m. | San Diego Convention Center, Halls G-H

2357 Travel Time from Cancer Center Is Associated with Disparities in Non-Hodgkin Lymphoma Diagnosis Among People Living with HIV in Malawi

Presenter: Meagan Harrington

 

1219 Physician-Assessed Vs. Patient-Reported Bleeding Scores in an Undiagnosed Clinic Population

Presenter: Callie Berkowitz, MD

 

1438 Understanding the Associations between High-Dose Methotrexate Pharmacokinetics and the Risk of Adverse Events in Children and Adolescents with Down Syndrome Associated High-Risk Acute Lymphoblastic Leukemia

Presenter: Kate Westmoreland, MD

 

1661.3 Trial in Progress – Alliance A052101: A Randomized Phase 3 Trial of Continuous Vs. Intermittent Maintenance Therapy with Zanubrutinib As Upfront Treatment in Older Patients with Mantle Cell Lymphoma

Presenter: Anne Beaven, MD

 

1114 The Impact of Chronic Hemolysis on Placental Angiogenesis in a Mouse Model of Sickle Cell Disease

Presenter: Nirupama Ramadas, PhD, MSc, BSc

 

1202 Impact of Natural Variation in Coagulation Factor Zymogens on Contact Pathway-Initiated Thrombin Generation

Presenter: Harish Eswaran, MD

 

2393 Feasibility and Implementation of the ASH Research Collaborative’s COVID-19 Outcomes in Myeloma and the Impact of Vaccines (COSMIC): A Decentralized, Real-World Evidence Study for Patients with Multiple Myeloma to Monitor Outcomes Related to COVID-19

Presenter: William Wood, MD, MPH

 

1481 Azacitidine and Venetoclax with or without Donor Lymphocyte Infusion in Relapsed AML Post Allo-HSCT: A Single-Institution Retrospective Study

Presenter: Daniel Peters, MD

 

1958 Population-Level Outcomes in Solitary Plasmacytoma: A Surveillance, Epidemiology, and End Results (SEER) Study

Presenter: Daniel Reef, MD

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Sunday, Dec. 8

Scientific Symposia

9:30 – 10:45 a.m. | Marriott Marquis San Diego Marina, Grand Ballroom 11-13

Impact of Antibiotic Exposure on Outcomes Following TCT

Presenter: Tessa Andermann, MD, MPH

 

Oral Presentation

9:30 – 11 a.m. | Marriott Marquis San Diego Marina, Grand Ballroom 5-6

451 Genetic Subclones Reveal Phenotypic Heterogeneity in Diffuse Large B-Cell Lymphoma

Presenter: Boya Wang, PhD

 

Poster Presentation

6 – 8 p.m. | San Diego Convention Center, Halls G-H

3005 High Tumor Mutational Burden Associates with Increased CD8 T-Cell Presence, Decreased Tumor Heterogeneity, and Increased AICDA Expression in an HIV-Inclusive Cohort of Diffuse Large B-Cell Lymphoma

Presenter: Jenny Coelho

 

2877 Phase 2a Study of SLS009, a Highly Selective CDK9 Inhibitor, in Combination with Azacitidine and Venetoclax for Relapsed/Refractory Acute Myeloid Leukemia after Prior Venetoclax Treatment

Presenter: Joshua Zeidner, MD

 

2923 Immune and Myeloid Differentiation Shape Transcriptome to Discriminate Evolutionary Stages of Cellular Transformation

Presenter: Lacey Williams, MD

 

3468 Phase 1 Trial of CD30-Directed, CCR4 Co-Expressing Chimeric Antigen Receptor T-Cells in Patients with CD30⁺ Cutaneous T-Cell Lymphomas Refractory to Brentuximab Vedotin

Presenter: Daniel Reef, MD

 

2577 Rebalancing Hemostasis in Hemophilia: Interplay between Antithrombin and Ancillary Thrombin Inhibitors

Presenter: Dougald Monroe, PhD

 

3683 Low Uptake of FDA-Approved Medications for Sickle Cell Disease Amongst the Adult Medicaid Population in North Carolina

Presenter: Joshua Rivenbark, MD, PhD

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Monday, Dec. 9

Oral Presentation

2:45 – 4:15 p.m. San Diego Convention Center | Hall B

919 CD30.CAR-T Cells Co-Expressing the CCR4 Chemokine Receptor in Relapsed/Refractory Hodgkin Lymphoma

Presenter: Natalie Grover, MD

 

Poster Presentation

 6 – 8 p.m. San Diego Convention Center | Halls G-H

4344 Immunogenomic Profiles of EBV-Associated Classic Hodgkin Lymphoma in an HIV-Inclusive Cohort

Presenter: Samantha Beck

 

5000 Joint Sickle Cell-Gynecology Clinic Improves Access to Reproductive Health

Presenter: Mofiyinfoluwa Obadina, MD