UNC Lineberger members Daniel J. Crona, PharmD, PhD, and Matthew Milowsky, MD, published a paper in the Oncologist that provided a systematic review of clinical trials and other studies focused on hydration regimens to identify strategies to prevent nephrotoxicity in cancer patients treated with cisplatin.
The researchers found that the best practice is short-duration, low-volume, outpatient hydration with magnesium supplementation and mannitol forced diuresis in select patients for safe use of cisplatin.
Crona, the study’s first author, is a UNC Lineberger member and assistant professor in the UNC Eshelman School of Pharmacy. Milowsky, the study’s senior and corresponding author, is a UNC Lineberger member, associate professor in the UNC School of Medicine and clinic medical director of the N.C. Cancer Hospital.
In addition to Crona and Milowsky, other authors from UNC include: A. Faso of the UNC Hospitals Department of Pharmacy, T.F. Nishijima of the UNC School of Medicine Division of Hematology and Oncology, and K.A. McGraw of the UNC-Chapel Hill Department of Library Sciences.
To read the full study, click here.