UNC Lineberger Oversight Committees
Find more information and resources about the UNC Lineberger Oversight Committees:
Oncology Protocol Review Committee (PRC)
The Oncology Protocol Review Committee (PRC) is a multidisciplinary standing committee of the UNC Lineberger Comprehensive Cancer Center.
Its charge is the peer review of investigator initiated, industry sponsored and cooperative group research protocols involving cancer patients, or those conducted by UNC investigators with a focus on cancer, prior to submission of the protocol to the UNC Institutional Review Board (IRB).
The PRC’s primary function is to ensure the scientific merit of the proposed research and ensure patient safety parameters of proposed studies and protocol amendments. The PRC also monitors study accrual (via annual renewal review) and recommends closure of under-performing trials.
Data and Safety Monitoring Committee (DSMC)
The UNC Lineberger Data and Safety Monitoring Committee (DSMC) provides ongoing safety monitoring for all cancer center investigator-initiated oncology clinical trials. This includes therapeutic, as well as interventional basic science, diagnostic, prevention, screening, and supportive care studies.
The DSMC is one of the committees responsible for oversight of data and safety monitoring on UNC Lineberger investigator-initiated trials (IITs).
Compliance Committee (CC)
Audits are conducted on UNC Lineberger investigator-initiated treatment trials to authenticate compliance and capture of accurate data through the UNC Lineberger Compliance Committee.
The committee’s main purpose is to support investigators and staff by ensuring the safety of study participants and compliance with protocols, regulations, and standard operating procedures (SOPs) for the clinical trials conducted at UNC Lineberger. This oversight is accomplished by a forum for review of clinical trial activities and dissemination of best practices information.