Clinical Trials

A selective listing of clinical trials for brain and central nervous system cancers that are currently available at UNC Lineberger Comprehensive Cancer Center.

Study PhaseStudy #Study Title and DescriptionPrincipal Investigator
Phase  IIA071401-CIRBPhase II Trial of SMO/AKT/NF2 inhibitors in Progressive Meningiomas with SMO/AKT/NF2 MutationsFrances Collichio, MD
Phase IIIEF-25Pivotal, Open-Label, Randomized Study of Radiosurgery with or without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases from Non-small Cell Lung Cancer (NSCLC)Simon Khagi, MD
Phase IIIOT-15-001A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide ChemotherapySimon Khagi, MD
Phase IIINCT02831959Effect of TTFields (150 kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-10 Brain Metastases Following Radiosurgery (METIS)Simon Khagi, MD


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