Daniel J. Crona

Daniel J. Crona, PharmD, PhD, is a UNC Lineberger Comprehensive Cancer Center member, Assistant Professor at UNC-Chapel Hill Eshelman School of Pharmacy.

Daniel J. Crona

PharmD, PhD
Assistant Professor
UNC-Chapel Hill
Molecular Therapeutics
GMB 1077, 120 Mason Farm Rd, CB# 7361
ChapelHill, NC 27599
(919) 966-4343

CV or Biosketch

Area of interest

My research interests focus on how common variations to genes that encode for proteins involved in drug influx, efflux, metabolism, and oncogenic signaling explain interindividual differences in pharmacokinetics (PK) and pharmacodynamics (PD) of targeted therapies used in oncology. Elucidation of the interplay between pharmacogenetic variants and determinants of PK and/or PD will invariably help to personalize treatment paradigms for cancer patients receiving targeted agents so that efficacy (e.g. survival) is maximized and toxicity minimized. As a tenure track assistant professor in the Division of Pharmacotherapy and Experimental Therapeutics at the UNC Eshelman School of Pharmacy, and as a faculty member in the UNC Center for Pharmacogenomics and Individualized Therapy, my translational research program focuses on testing associations between pharmacogenetic variants and hematology/oncology phenotypes of interest, in both retrospective and prospective clinical studies, and then revealing molecular mechanisms that underlie these genotype-phenotype associations in my laboratory. Long-term my research focus will also expand to investigate the relationships between pharmacogenetics, PK and PD to optimize treatment and dose selection for patients receiving novel anti-cancer agents, where the clinical pharmacology of these agents has yet to be elucidated (e.g. antibody-drug conjugates, immunotherapeutics, and kinase inhibitors). My research passions include: hematology/oncology, translational research, implementation of clinical pharmacogenetics, and novel clinical trial design. My over-arching career goal is to develop further expertise in translational research and as a clinical pharmacologist of targeted hematology/oncology pharmacotherapeutics.

Awards and Honors

2008 Rho Chi Pharmacy Academic Honor Society Inductee
2008 Phi Lambda Sigma Pharmacy Leadership Honor Society Inductee
2008–2010 Kaiser Permanente Kent M. Nelson Memorial Clinical Pharmacy Scholar, CU Skaggs School of Pharmacy and Pharmaceutical Sciences
2013 Frank Porter Graham Honor Society Inductee, UNC Graduate School
2014 Kathryne A. Brewington Award (2014–2015 Outstanding Graduate Student in Pharmaceutical Sciences), UNC Eshelman School of Pharmacy

Find publications on PubMed