G. Greg Wang

PhD & Assistant Professor, Dept of Biochemistry and Biophysics, Cancer Cell Biology, School of Medicine, UNC-Chapel Hill

G. Greg Wang

PhD & Assistant Professor
Dept of Biochemistry and Biophysics and Cancer Cell Biology Program
School of Medicine
UNC-Chapel Hill

405 West Drive, UNC Cancer Center, LCCC room 31-327
Chapel Hill, NC 27599

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Area of interest

With an emphasis on chromatin biology and cancer epigenetics, our group focuses on mechanistic understandings of how chemical modifications of chromatin define distinct patterns of human genome, control gene expression, and regulate cell proliferation versus differentiation during development, and how their deregulations lead to oncogenesis. Multiple on-going projects employ modern biological technologies to: 1) biochemically isolate and characterize novel factors that bind to histone methylation on chromatin, 2) examine the role of epigenetic factors (chromatin-modifying enzymes and chromatin-associated factors) during development and tumorigenesis using mouse knockout models, 3) analyze epigenomic and transcriptome alternation in cancer versus normal cells utilizing next-generation sequencing technologies, 4) identify novel oncogenic or tumor suppressor genes associated with leukemia and lymphoma using shRNA or CRSIPR library-based screening. We are also working together with UNC Center of Drug Discovery to develop and examine the small-molecule inhibitors for chromatin-associated factors as novel targeted cancer therapies.

Awards and Honors

1994-1996       Undergraduate merit-based scholarship (People’s Fellowship), Fudan University, China
2000                Union Medical Award, Fudan University Medical Center, China
2007                C. H. Li Memorial Scholar Fund Scholar Award, the Rockefeller University
2008-2010       Leukemia & Lymphoma Society (LLS) Fellow Award (named as the John C. Newman Researcher of LLS)
2008                Irvington Institute - Cancer Research Institute postdoctoral fellowship (declined)
2010-2015      Howard Temin 'Pathway to Independence' Award in Cancer Research (K99/R00), NIH/NCI
2011-2012      Martin D. Abeloff, MD V Scholar (top rating), the V Foundation for Cancer Research
2013               Jefferson Pilot Fellowships in Academic Medicine Award, UNC Medical School
2013-2014      American Society of Hematology (ASH) Scholar Award in Basic Science
2014-2016      Janet D. Rowley Medical Research Award, Gabrielle's Angel Foundation for Cancer Research
2014-2015      Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer Research

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