Mauro Calabrese

Mauro Calabrese, PhD, is a UNC Lineberger Comprehensive Cancer Center member and Assistant Professor at UNC-Chapel Hill in the Department of Pharmacology. Calabrese Lab focuses on Genomics.

Mauro Calabrese

Assistant Professor
UNC-Chapel Hill
Cancer Genetics

120 Mason Farm Road, Genetic Medicine Building, Room 4093
Chapel Hill, NC 27599

Area of interest

Long noncoding RNAs (lncRNAs) represent an emerging and diverse collection of RNA-based cofactors that play key roles in human health often through the regulation of gene expression. The human genome encodes 10,000 such lncRNA genes, which, collectively, harbor a vast, unharnessed therapeutic potential. The majority have not been studied in any context, yet many are conserved, and initial studies have already shown defects in lncRNA function affect many fundamental aspects of tumorigenesis, including metastasis, cell division, angiogenesis, and the control of cell death. While emergent works continue to discover new and critical roles for lncRNAs in health and disease, the mechanisms by which these molecules function remain unknown and unpredictable. Our long-term mission is to define basic mechanisms through which lncRNAs function and apply this knowledge to develop new therapeutic strategies to modulate their activities across disease states, focusing on cancer.

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