Nicholas Brown

Nicholas Brown is a UNC Lineberger Comprehensive Center member and Assistant Professor of Pharmacology. Brown Lab is interested in understanding how enzymes function by studying the cell processes in vitro.

Nicholas Brown

Assistant Professor
UNC- Chapel Hill
Pharmacology
Molecular Therapeutics

120 Mason Farm Raod
4009 Genetic Medicine Bldg. , CB 7365
Chapel Hill, NC 27599
(919) 966-1307


Area of interest

A multitude of enzymes work together to drive the events of the eukaryotic cell cycle. These enzymes must be tightly regulated to prevent disastrous cellular consequences such as uncontrolled cell division and deregulation of the cell cycle, which are the hallmarks of cancer. A biochemical and structural description of these pathways is difficult because of the massive multi-protein complexes involved. To design better therapies, my overarching goal is to understand the system of inter- and intra-molecular interactions that dynamically regulate the catalytic mechanisms of molecular machines to precisely time the events of the cell cycle.

Awards and Honors

  • Baylor College of Medicine Verna and Marrs McLean Award, 2006 
  • Gulf Coast Consortia/Keck Center Pharmacoinformatics Training Program Fellowship, 2008-2010
  • Gulf Coast Consortia/Keck Center Biomedical Discovery from Large Scale Data Sets Training Program Fellowship, 2010- 2011 
  • Jane Coffin Childs Memorial Fund for Medical Research Fellowship, 2012-2015 
  • Leukemia and Lymphoma Society Special Fellowship, 2015-2017 
  • National Cancer Institute (NCI) Career Transition Award, 2017-2020 

Find publications on PubMed 

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