Samantha Pattenden

Samantha Pattenden, PhD, is a UNC Lineberger Comprehensive Cancer Center member and is located in the Center for Integrative Chemical Biology and Drug Discovery. The Pattenden lab is uniquely positioned to work with investigators to adapt state-of-the-art chromatin-based technology for high throughput screening and to develop new ways to interrogate chromatin biology for therapeutic discovery and cancer diagnostics.

Samantha Pattenden

Director of Applied Epigenetic Screening Technologies, Center for Integrative Chemical Biology and Drug Discovery

Research Assistant Professor, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy

University of North Carolina at Chapel Hill

Molecular Therapeutics

3214 Marsico Hall
Chapel Hill, NC 27599
919-843-8459


Area of interest

    Since the identification and preclinical validation of cancer therapeutic targets and biomarkers poses a significant bottleneck in drug discovery pipelines, the Pattenden lab is focused on developing innovative techniques in chromatin-based therapeutic target discovery and cancer diagnostics. Our research program enables discovery of novel molecular targets, pathways and mechanisms both within our laboratory and in collaboration with outside investigators. Our central strategy exploits tumor-specific changes in chromatin signature, a universal feature that is directly linked with transcriptional activation, DNA damage repair, replication, RNA processing, and nuclear organization. Since chromatin signatures offer a comprehensive overview of the rewiring of transcriptional networks that accompanies processes such as cellular differentiation, tumor growth, metastasis, and therapeutic resistance, they are frequently more reliable in predicting cell behavior than gene expression profiles alone.  We have developed a unique set of chromatin biology research tools that are available to UNC investigators including high-throughput Formaldehyde Assisted Isolation of Regulatory Elements (FAIRE), and Assay for Transposase-Accessible Chromatin (ATAC) screens (in collaboration with Dr. Ian Davis) and a patented cavitation enhancing technology for increased speed and consistency of DNA and chromatin fragmentation in an acoustic sonicator (in collaboration with Dr. Paul Dayton).

Awards and Honors

1998 University of Toronto Open Fellowship, University of Toronto
1999 Frank Fletcher Memorial Fund, Ontario Student Opportunity Trust Fund Fellowship, University of Toronto
1999 University of Toronto Open Fellowship, University of Toronto
2000 Frank Fletcher Memorial Fund, Ontario Student Opportunity Trust Fund Fellowship, University of Toronto
2000 KM Hunter/MRC Doctoral Research Fellowship, Canadian Institutes for Health Research
2001 Frank Fletcher Memorial Fund, Ontario Student Opportunity Trust Fund Fellowship, University of Toronto
2002 Vision Science Research Program Fellowship, Ontario Student Opportunity Trust Fund, University of Toronto
2003 Vision Science Research Program Fellowship, Ontario Student Opportunity Trust Fund, University of Toronto
2004 NSERC Postdoctoral Fellowship, Natural Sciences and Engineering Research Council of Canada
2004 Professional Development Award, Stowers Institute for Medical Research
2016 IBM Junior Faculty Development Award, University of North Carolina at Chapel Hill

Find publications on PubMed

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