Yanguang (Carter) Cao

Yanguang Cao, PhD, is a UNC Lineberger Comprehensive Cancer Center member and Assistant Professor of Pharmaceutical Sciences at UNC-Chapel Hill. Cao Lab is interested in developing system pharmacology platforms (models) integrating PK/PD to facilitate drug development and optimize therapeutics for cancers and autoimmune diseases.

Yanguang (Carter) Cao

Assistant Professor at UNC at Chapel Hill
Adjunct Assistant Professor at SUNY Buffalo
Division of Pharmacotherapy and Experimental Therapeutics
UNC Eshelman School of Pharmacy
University of North Carolina at Chapel Hill
2318 Kerr Hall, Campus Box # 7569
Chapel Hill, NC 27599-7569
919-966-4040 (office)
Kerr Hall 2319
Chapel Hill, NC 27599
919-966-4040


CV or Biosketch

Area of interest

My area is broadly focusing on system pharmacology and pharmacokinetics/pharmacodynamics (PK/PD) of cancer therapeutics. Specially, we take integrated approaches to leverage mathematical, statistical, and experimental studies to explore spatial/temporal coordination of immune system and anti-cancer therapeutics. We primarily work on therapeutic antibodies, cell-based therapies, and nanoparticles. One of our recent modeling concepts, “minimal physiologically-based PK” model, takes a reductionist view of physiology and pharmacokinetics to capture the essential process that governs antibody system dispositions. This modeling concept has been taken to predict antibody deposition in solid tumors and optimize the dynamic interactions between antibodies and their corresponding targets.

We are now pursuing topics:

  • Integrating antibody PK/PD and host system to optimize antibody-based therapies for cancers
  • Minimal physiologically-based PK models for monoclonal antibodies.
  • Physiologically-based PK models for drugs encapsulated in liposomes.
  • Exploring spatial/temporal harmonization between immune systems and immunotherapy.
  • Novel PET and optical imaging techniques to track therapeutic molecules and immune system.

Find publications on PubMed


Filed under: