The Serody laboratory is focused on a better understanding of transplantation and tumor immunology and ways to use this to improve the outcome for patients undergoing bone marrow or stem cell transplantation and for the treatment of certain types of cancer. We have pioneered a number of approaches that have become standard for these evaluations including the use of transgenic mice expressing specific colored flurorochromes to track the migration of immune cells after bone marrow transplantation, the use of genetically modified mice that mimic human tumors to test immunotherapy, the use of dendritic cells loaded with tumor antigens to treat patients with breast cancer and the role of proteins important in migration in the biology of graft-versus-host disease (GVHD). The laboratory focuses on three broad areas; acute and chronic GVHD biology, pre-clinical models to test tumor vaccines and the function of immune cells in the ability of tumors to grow locally or metastasize and tumor vaccine treatments for patients.