UNC Lineberger Comprehensive Cancer Center will host its 43rd annual scientific symposium on April 29-30, 2019, at the William and Ida Friday Center for Continuing Education in Chapel Hill, North Carolina.

**Online registration is now closed. Onsite registration will be available.**


“Dysregulated Signaling Pathways in Cancer: Insights into Novel Mechanisms and Therapeutic Approaches”


Albert S. Baldwin, PhD, Greg Wang, PhD, Yue Xiong, PhD, and Qing Zhang, PhD

Confirmed Speakers

C. David Allis, PhD
Rockefeller University
When Genetics and Epigenetics Collide: Insights Gained into Human Cancer

Scott Armstrong, MD, PhD
Dana-Farber Cancer Institute
Targeting Chromatin Complexes to Modulate Gene Expression in Cancer

Arul Chinnaiyan, MD, PhD
University of Michigan
The Application of Integrative Sequencing for Precision Oncology

Michael Emanuele, PhD
UNC Lineberger Comprehensive Cancer Center
Ubiquitin Signaling in Cell Cycle Control and Cancer”

Kun-Liang Guan, PhD
University of California, San Diego
The Hippo Pathway in Cell Growth, Organ Size, and Tumorigenesis

Guang Hu, PhD
National Institute of Environmental Health Sciences
Regulation of the Naïve and Primed Pluripotent State

William G. Kaelin, Jr, MD
Dana-Farber Cancer Institute
The von Hippel-Lindau Tumor Suppressor: Insights into Oxygen Sensing and Drugging the Undruggable

William Kim, MD
UNC Lineberger Comprehensive Cancer Center
Regulation of the Bladder Cancer Microenvironment

Christine Lovly, MD
Vanderbilt University
New Ways to Target EGFR Signaling in Lung Cancer

Charles Sawyers, MD
Memorial Sloan Kettering Cancer Center
Lineage Plasticity in Prostate Cancer

Mario Suva, MD, PhD
Massachusetts General Hospital
Dissecting Human Gliomas by Single-Cell Genomics

Cheryl Walker, PhD
Baylor College of Medicine
A New Role for Epigenetic “Readers, Writers and Erasers” in Cytoskeleton Remodeling

Greg Wang, PhD
UNC Lineberger Comprehensive Cancer Center
DNMT3A, de novo DNA Methylation and Blood Cancer

Yue Xiong, PhD
UNC Lineberger Comprehensive Cancer Center
TET DNA Dioxygenases in Interferon Signaling and Tumor Immunity

Jen Jen Yeh, MD
UNC Lineberger Comprehensive Cancer Center
Pancreatic Cancer Subtypes for Precision Medicine

Qing Zhang, PhD
UNC Lineberger Comprehensive Cancer Center
Novel von Hippel-Lindau Regulatory Pathways in Cancer

Jean Zhao, PhD
Dana-Farber Cancer Institute
Harnessing the Synergy of Immunotherapy and Targeted Therapy for Cancer Treatment: From Mouse Models to Human Therapy