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44th Annual UNC Lineberger Cancer Center Scientific Symposium

April 28-30, 2021

Please note that the schedule is subject to change


Wednesday, April 28

Broad targets of immunotherapy

Session Chair: Lishan Su, PhD, Charles Gordon Smith Professor, Institute of Human Virology, Department of Pharmacology, Microbiology and Immunology, University of Maryland School of Medicine

 

1:00 p.m. — Welcome

UNC Lineberger Director Shelley Earp, MD


1:10-1:50 p.m. — “Normal and Neoplastic Stem Cells: Therapies for Autoimmune and Deficiency Disease and Targets for Immunotherapies

Irving Weissman, MD, director, Stanford Institute of Stem Cell Biology and Regenerative Medicine, Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Stanford University.


1:55-2:25 p.m. — “The pDC/IFN axis in chronic virus infection and cancer immunotherapy”

Lishan Su, PhD, Charles Gordon Smith Professor, Institute of Human Virology, Department of Pharmacology, Microbiology and Immunology, University of Maryland School of Medicine.


2:25-3:00 p.m. — Break


3:00-3:30 p.m. — “Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity

Victor Engelhard, PhD, professor of Microbiology, Immunology, and Cancer Biology, and director, Carter Immunology Center, University of Virginia.


3:35-4:05 p.m. — “Generating host-wide resident memory T cell responses to cancer”

Mary Jo Turk, PhD, O. Ross McIntyre, M.D. Endowed Professor of Microbiology and Immunology and co-director, Immunology and Cancer Immunotherapy Program, Norris-Cotton Cancer Center, Dartmouth University School of Medicine.


4:10-4:40 p.m. — “TGF-beta signaling in T cell function and tumor immunity

Yisong Wan, PhD, professor of Microbiology and Immunology, University of North Carolina and UNC Lineberger.


Thursday, April 29

Checkpoint inhibitors and other immunoregulatory mechanisms

Session Chair: Ben Vincent, MD, assistant professor and joint faculty member in the Department of Microbiology and Immunology, University of North Carolina and UNC Lineberger

 

1:00-1:40 p.m. — “The Biology Behind PD-1 Checkpoint Blockade”

Arlene Sharpe, MD-PhD, George Fabyan Professor of Comparative Pathology and chair of the Dept. of Immunology, Harvard Medical School.


1:45-2:00 p.m. — “Venetoclax increases intra-tumoral effector T cells and anti-tumor efficacy in combination with anti-PD1

Ryan Duggan, senior scientist, Oncology Discovery group, AbbVie, Inc.


2:05-2:35 p.m. — “Immunomodulatory mechanisms in pancreatic cancer

Yuliya Pylayeva-Gupta, PhD, associate professor of Genetics, University of North Carolina and UNC Lineberger.


2:40-3:00 p.m. — Break


3:00-3:30 p.m.“The double-edged sword of non-canonical autophagy”

Jennifer Martinez, PhD, principal investigator, Inflammation and Autoimmunity Group, National Institute of Environmental Health Sciences.


3:35-4:05 p.m. CAR-T Cell Trials at UNC”

Natalie Grover, MD, assistant professor of Medicine, University of North Carolina, and Clinical Director of Cellular Therapy Program, UNC Lineberger.


4:10-4:40 p.m. — “CAR-T Cells from Bench to Application”

Gianpietro Dotti, MD, professor of Microbiology and Immunology, University of North Carolina, and director of the Cellular Immunotherapy Program, UNC Lineberger.


Friday, April 30

Beyond conventional immunotherapy

Session Chair: Jennifer Webster-Cyriaque, PhD, DDS, professor of Dental Ecology, University of North Carolina and UNC Lineberger

 

1:00-1:40 p.m. — “Beyond immune checkpoint blockade: emerging strategies

Tak Mak, PhD, director of the Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, and professor of Medical Biophysics and Immunology, University of Toronto.


1:45-2:15 p.m. — “Targeting the Microbiome in Cancer Immunotherapy

Giorgio Trinchieri, MD, vice-chairperson, Laboratory of Experimental Immunology, National Cancer Institute.


2:20-2:50 p.m. — Break


2:50-3:20 p.m. — “Metabolic impact on cancer immunity and therapy 

Weiping Zou, MD-PhD, Charles B. de Nancrede Professor of Pathology, Immunology, Biology, and Surgery, University of Michigan.


3:25-3:55 p.m. — “Innate immunity, microbiota and cancer”

Jenny Ting, PhD, William Rand Kenan Distinguished Professor of Genetics and Microbiology and Immunology, University of North Carolina and UNC Lineberger.


4:00-4:30 p.m. — “The role of the gut-tumor microbial axis in modulating the immune response”

Florencia McAllister, MD, assistant professor, MD Anderson Cancer Center.