Researchers find clues to drug resistance in medulloblastoma subtype

January 13, 2020

University of North Carolina Lineberger Comprehensive Cancer Center researchers have new evidence to explain how drug resistance develops in a major subtype of medulloblastoma, the most common invasive brain tumor in children. A UNC Lineberger team led by Timothy Gershon, MD, PhD and Kirk Wilhelmsen MD, PhD, reported in the journal Nature Communications that they … Continued

Researchers identify possible approach to block medulloblastoma growth

October 23, 2019

University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a potential approach to stop the growth of the most common type of brain tumor in children. UNC Lineberger’s Timothy Gershon, MD, PhD and colleagues reported in the journal Development that by blocking a signal called GSK-3, they could control tumor growth in a … Continued

Grateful patient works with lab team to find cancer therapies

June 28, 2019

Once cancer treatment ends, hopefully with a clean bill of health, most patients hightail it away from the hospital, putting the endless batteries of tests, needle sticks and scans in their rearview mirror. So it’s a rare patient that returns of their own volition, and rarer still, becomes a lab volunteer. But that’s exactly what David Hesmer did.

Stem cells show promise as drug delivery tool for childhood brain cancer

August 27, 2018

UNC Lineberger’s Shawn Hingtgen, PhD, and his collaborators showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children.

Removing a brain tumor makes remaining cancer more aggressive

July 5, 2016

A study led by UNC Lineberger member Shawn Hingtgen, PhD, has determined that removing a glioblastoma tumor from the brain causes any cancer left behind to grow much faster than the original tumor did. The findings from the Neuro-Oncology paper illustrate the effect of surgery on the brain and tumor and the need to rethink how to treat the disease differently after the surgery.