E-cigs can trigger same lung changes seen in smokers, emphysema

August 22, 2019

E-cigarette “vaping” is widely assumed to be safer than cigarette smoking, but scientists at the University of North Carolina have uncovered evidence suggesting that vaping promotes the same cellular responses found in smokers with emphysema. In a study published in the American Journal of Respiratory and Critical Care Medicine, the UNC scientists found that the lungs of vapers … Continued

Study provides insights behind hyperactivation of key cell proliferation signal

April 19, 2019

The idea was simple: find the faulty signals that drive cancerous growth in cells, and block them. But what University of North Carolina Lineberger Comprehensive Cancer Center researcher Pengda Liu, PhD, has discovered, when it comes to cancer, even straightforward concepts can become complicated. “When you find a target and inhibit it, you find the … Continued

Scientists uncover mechanism cells use to deactivate a signal that’s hyperactive in cancer

January 31, 2019

University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators have discovered how a cellular signal that’s abnormally hyperactive in cancer can be deactivated. In the journal Cell Reports, UNC Lineberger’s M. Ben Major, PhD, and colleagues published a paper on how the WNT signaling pathway is regulated. WNT proteins increase tumor onset, growth … Continued

Researchers publish milestone review on the role of cell signaling proteins in cancer

January 29, 2019

University of North Carolina Lineberger Comprehensive Cancer Center scientist Antonio “Tony” Amelio, PhD, is not necessarily looking for the “smoking gun” of cancer biology, or one single cause of cancer. Instead, he’s looking into how a family of newly described proteins involved in the cellular stress response can cause a complex ripple effect of changes … Continued

Insights about prostate cancer resistance could lead to treatment strategies

October 5, 2018

In the journal Molecular Cell, researchers led by UNC Lineberger’s G. Greg Wang, PhD, and H. Shelton Earp, MD, describe the role of a protein variant called androgen receptor variant 7 (AR-V7), which is an alternative form of the androgen receptor that plays a key role in prostate cancer development and treatment.