February 13, 2020
CAR-T therapy gives patient options after cancer returns
When traditional cancer treatment options failed, Sabrina Shelton's care team referred her to UNC for a CAR-T therapy clinical trial.
Tag: CAR-T
January 30, 2020
UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells
A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease their activity level in the case of severe side effects. In a study published in Cancer Cell, researchers led by UNC Lineberger’s Gianpietro Dotti, …
May 20, 2019
UNC Lineberger designs, develops and delivers CAR-T therapy to attack cancers
Jonathan Serody, MD, explains in a two-minute video the action behind chimeric antigen T-cell, or CAR-T, immunotherapy and how UNC Lineberger is designing, developing and delivering CAR-T therapies to treat cancers that fail to respond to standard treatments.
November 27, 2018
Nature: Genetically modified T cells target lymphoma
October 23, 2018
The Mary Kay Foundation awards UNC Lineberger $100,000 cancer research grant
Gianpietro Dotti, MD, will use the $100,000 grant to conduct research into the use of cellular immunotherapy to treat solid tumors such as neuroblastoma, glioblastoma, ovarian cancer, pancreatic cancer and triple negative breast cancer.
February 28, 2018
Researchers identify molecular target for brain cancer, develop immunotherapy approach to attack it
A team led by UNC Lineberger's Gianpietro Dotti, MD, has engineered immune cells to hunt glioblastoma, the most lethal primary brain tumor. They presented their findings in Science Translational Medicine.
November 21, 2017
Leukemia & Lymphoma Society awards grant to Savoldo for immunotherapy research
The Leukemia & Lymphoma Society grant will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."
April 10, 2017
UNC Lineberger receives $4 million gift to support promising new cancer treatment
Seeking to help in the development of treatments for metastatic cancer, Alice Lehman of Charlotte has donated $4 million to further the work of UNC Lineberger's new cellular immunotherapy research program.
February 28, 2017
UNC Lineberger launches innovative cellular immunotherapy program
UNC Lineberger, with its U.S. FDA-approved Good Manufacturing Practices, or “clean,” facility, is one of only a select academic centers in the United States with the capability to genetically modify patient immune cells for clinical use. This makes it possible for people who live in the Southeastern U.S. to stay closer to home to undergo cellular immunotherapy treatment.