Gianpietro Dotti Archives - UNC Lineberger Comprehensive Cancer Center

Drs. Barbara Savoldo, Gianpietro Dotti, Robert L. Ferris, Natalie Grover and Jonathan S. Serody at the UNC Health Foundation’s Game Changers event on November 4, 2025

This gift will fuel the next generation of cancer treatments, supporting all aspects of the UNC Lineberger Cellular Immunotherapy Program with an emphasis on clinical trials, expansion of the cellular therapeutics facility, and faculty recruitment and retention.

Human cells with acute myelocytic leukemia (AML) in the pericardial fluid, shown with an esterase stain at 400x magnification.

Gianpietro Dotti, MD, Paul Armistead, MD, PhD, and colleagues have created a new cellular immunotherapy that targets acute myeloid leukemia (AML) cells without impacting normal blood production, which is one of the major challenges associated with AML treatment.

Kristy Ainslie, PhD, and colleagues were awarded a $12.8 million NIH Program Project grant to form a collaborative team researching biomaterials to boost the body’s own immune system to enhance cell-based immunotherapy to fight glioblastoma.

The Persistence Therapeutics leadership team in the lab: Gianpietro Dotti, Charles Buchen, Pritha Agarwalla, and Yevgeny Brudno.

A dime-sized technology could transform CAR-T therapy by creating a simpler, more affordable procedure that targets many cancer types and can be done at almost any hospital.

Headshots of the 11 honorees. Caption available with names.

Eleven UNC Lineberger Comprehensive Cancer Center members were named as 2025 Highly Cited Researchers by Clarivate for publishing some of the most influential scientific papers during the past decade.

A dermatologist examines the skin of a patient's arm with a dermatoscope.

Researchers found that inhibiting a problematic protein in the body helps immunotherapies and CAR-T therapy to better fight off melanoma.

Scientific illustration of a CAR-T cell attacking a cancer cell.

Gianpietro Dotti, MD, and colleagues report in Nature Immunology they have identified a cocktail of three different drugs that can be used to generate more robust CAR-Ts to fight cancer.

Headshots of nine UNC Lineberger faculty members who were named Clarivate 2024 Highly Cited Researchers.

Nine UNC Lineberger members wrote some of the most influential scientific papers in the past decade, according to an independent analysis of research publications.

Gianpietro Dotti, MD, and Xin Zhou, PhD, report in Nature Cancer that a novel immunotherapy approach utilizing natural killer T (NKT) cells produced significant antitumor activity in solid tumors.

Tag: Gianpietro Dotti

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