NCI awards $2.2M to Pylayeva-Gupta to investigate immune responses in pancreatic cancer

April 17, 2019

The National Cancer Institute has awarded a five-year grant of more than $2.2 million to UNC Lineberger’s Yuliya Pylayeva-Gupta, PhD, to support her research into the immune response in pancreatic cancer, one of the deadliest cancers. “Understanding the role of immune regulation in pancreatic cancer represents a crucial stepping stone on our way to advancing … Continued

Studies explore mechanisms behind obesity-cancer link

March 31, 2019

New studies led by University of North Carolina Lineberger Comprehensive Cancer Center researchers explore biological mechanisms behind obesity and its link with cancer. Research findings presented at the American Association for Cancer Research Annual Meeting 2019 explore possible reasons for obesity-related resistance to breast cancer treatment and possible strategies to overcome obesity-related immune suppression in … Continued

Four paws, two handlers, one great comfort: SCHALL

March 27, 2019

A weary look crosses the face of a teenage girl; her jaw tightens, and her body tenses. Another day, another needle stick — a typical appointment for a pediatric cancer patient. But then, the tapping of nails on a shiny floor brings a different expression — a smile — for SCHALL, the rehabilitative facility dog … Continued

Precision oncology insights revealed for colorectal cancer

March 19, 2019

Next-generation sequencing of tumor DNA from patients with colorectal cancer revealed genetic alterations that were linked to different survival and treatment outcomes in an analysis led by a University of North Carolina Lineberger Comprehensive Cancer Center researcher. The findings, published in the Journal of Clinical Oncology, could help define strategies to more effectively treat colorectal … Continued

Scientists discover key enzyme in breast cancer proliferation, treatment resistance

March 12, 2019

Basal-like breast cancer is the most aggressive and difficult-to-treat subtype of breast cancer, and it largely overlaps with the triple-negative classification of the disease. Patients are in dire need of improved therapies that attack the underlying cellular features of these types of breast cancer. Now scientists at the University of North Carolina Lineberger Comprehensive Cancer … Continued

Potential treatment strategy uncovered for pancreatic cancer

March 4, 2019

Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center discovered a technique to make pancreatic cancer cells reliant on one energy source and then starve them of it — a finding that has led to clinical studies of a novel treatment strategy for one of the deadliest cancers. Published in the journal Nature … Continued

Patient-reported symptoms offer insight for clinical trials

February 25, 2019

University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators found that allowing patients to write, in their own words, about treatment-related symptoms they experienced while participating in clinical trials can provide valuable information. In a first-of-its-kind study published in the Journal of the American Medical Informatics Association, researchers examined two different methods of … Continued

World traveler finds cancer is just another mountain to climb

February 25, 2019

For a seasoned traveler like Anita McAllister, you’d think exploring the mountainous terrain around Machu Picchu was the most memorable and challenging experience of her life. But a breast cancer diagnosis sent her on a new journey, one that has expanded her horizons beyond the mountains of Peru and has given her a new purpose. … Continued

Researchers discover potential attack strategy for aggressive breast cancer

February 20, 2019

University of North Carolina Lineberger Comprehensive Cancer Center researchers have designed a novel way to attack an aggressive breast cancer. By working with a drug development company, they hope their laboratory discovery will translate to a new treatment combination in the clinic in the future. The latest finding, described in the journal Cancer Cell International, … Continued