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Gianpietro Dotti and Yang Xu

February 3, 2020

Researchers develop method to engineer immune cells so they grow even in hostile tumors

Tumors can create a hostile environment for cancer-fighting immune cells. In a new study, University of North Carolina Lineberger Comprehensive Cancer Center researchers have developed a method for engineering immune cells to improve their survival and proliferation, even within a hostile tumor. Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, report in the journal Nature …

Gianpietro Dotti and Peishun Shou

January 30, 2020

UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells

A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease their activity level in the case of severe side effects. In a study published in Cancer Cell, researchers led by UNC Lineberger’s Gianpietro Dotti, …

Joshua Zeidner, MD

January 14, 2020

Phase I study indicates drug could boost immune function in blood cancers

An early-stage clinical study investigating a method of boosting the body’s defenses against two blood cancers found the drug pomalidomide could be safely added to conventional treatments, and help improve immune function. University of North Carolina Lineberger Comprehensive Cancer Center researcher Joshua Zeidner, MD, assistant professor in the UNC School of Medicine Division of Hematology/Oncology, …