September 24, 2018
A study led by UNC Lineberger’s Stephanie Wheeler, PhD, found that black women were more likely than white women to report not taking endocrine therapy for breast cancer as prescribed, which could help explain why hormone-receptor positive breast cancer mortality is higher among black women.
August 29, 2018
In the journal Blood Advances, UNC Lineberger’s Ben Vincent, MD, Paul Armistead, MD, PhD, and their collaborators reported early findings from a new study that could aid in the development of immune-based treatments that are tailored to individual leukemia patients who are undergoing stem cell transplantation.
August 27, 2018
UNC Lineberger’s Shawn Hingtgen, PhD, and his collaborators showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children.
August 3, 2018
In the journal Cancer Immunology Research, scientists led by UNC Lineberger's Yuliya Pylayeva-Gupta, PhD, revealed that a molecule called interleukin-35 plays a role in suppressing cancer-fighting immune cells in pancreatic cancer.
July 19, 2018
In a study published in the journal Science, researchers led by UNC Lineberger's Qing Zhang, PhD, suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer.
July 10, 2018
In a preclinical study, researchers led by UNC Lineberger's Ryan Miller, MD, PhD, investigated whether the location of where the mutation occurred within the sequence of the PIK3CA gene affected the mutation’s ability to help drive cancerous growth. They also evaluated whether the location of the mutation would affect the cancer's response to certain treatments.
June 12, 2018
In a collaborative, multi-institution effort to map the genetic and genomic changes in cancer, researchers led by UNC Lineberger's Katherine Hoadley, PhD, analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back. Their findings were published in Cell Reports.
June 4, 2018
UNC Lineberger researchers and colleagues led by Catherine C. Coombs, MD, reported research findings at the 2018 American Society of Clinical Oncology Annual Meeting that showed blood cell mutations accounted for as many as 8 percent of the mutations identified in large-scale genetic sequencing efforts at two major academic centers.
May 24, 2018
Researchers led by UNC Lineberger's Chad Pecot, MD, report in the journal Nature Communications that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.
May 21, 2018
In the journal Cancer Research, UNC Lineberger’s William Y. Kim, MD, Benjamin G. Vincent, MD, and colleagues reported they have developed a mouse model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to immunotherapy treatments called checkpoint inhibitors.
