Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells. Cancer Cell, 2019 in press

  • Du H, Hirabayashi K, Ahn S, Kren NP, Montgomery SA, Wang X, Tiruthani K, Mirlekar R, Michaud D, Greene K, Herrera SG, Xu Y, Sun C, Chen Y, Ma X, Ferrone CR, Pylayeva-Gupta Y, Yeh JJ, Liu R, Savoldo B, Ferrone S, Dotti G.

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and switch II conformation. Nat Commun. 2019 Jan 15;10(1):224.

  • Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BPK, St-Germain J, Cook JD, Valencia-Sama I, Grant BMM, Herrera SG, Miao J, Raught B, Irwin MS, Lee JE, Yeh JJ, Zhang ZY, Tsao MS, Ikura M, Ohh M.

The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation. PLoS One. 2018 Aug 14;13(8):30202272.

  • Innocenti F, Owzar K, Jiang C, Etheridge AS, Gordân R, Sibley AB, Mulkey F, Niedzwiecki D, Glubb D, Neel N, Talamonti MS, Bentrem DJ, Seiser E, Yeh JJ, Van Loon K, McLeod H, Ratain MJ, Kindler HL, Venook AP, Nakamura Y, Kubo M, Petersen GM, Bamlet WR, McWilliams RR.

Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy. J Surg Oncol. 2018 Sep:188(3):455-462.

  • Cools KS, Sanoff HK, Kim HJ, Yeh JJ, Stitzenberg KB.

Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature. 2018 Jun. 558(7711):600-604.

  • Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, KulkeMH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG.

Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine. Cancer Discovery. 2019 Jun 14. Pii:CD-18-9275. Epub ahead of print.

  • Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S,Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Da Silva A, Nadres B, Van Seventer EE, Shahzade HA, St Pierre JP, Burke KP, Clancy TE, Cleary JM, Doyle LA, Jajoo K, McCleary NJ, Meyerhardt JA, Murphy JE, Ng K, Patel AK, Perez K, Rosenthal MH, Rubinson DA, Ryou M, Shpairo GI, Sicinska E, Silverman SG, Nagy RJ, Lanman RB, Knoerzer D, Welsch DJ, Yurgelun MB, Fuchs CS, Garraway LA, Getz G, Hornick JL, Johnson BE, Kulke MH, Mayer RJ, Miller JW, Shyn PB, Tuveson DA, Wagle N, Yeh JJ, Hahn WC, Corcoran RB, Yeh JJ, Carter SL, Wolpin BM.

Application of integrated drug screening/kinome analysis to identify inhibitors of gemcitabine-resistant pancreatic cancer cell growth. SLAS Discovery. 2018 May 1:2472555218773045. Epub ahead of print.

  • Krulikas LJ, McDonald IM, Lee B, Okumu DO, East MP, Gilbert TSK, Herring LE, Golitz BT, Wells CI, Axtman AD, Zuercher WJ, Willson TM, Kireev D, Yeh JJ, Johnson GL, Baines AT, Graves LM.

Impact of formulation on iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer. Cancer Chemotherapy Pharmacology. 2018 Jun;81(6):991-998.

  • Byrne JD, Jajja MRN, O’Neill AT, Schorzman AN, Keller AW, Luft JC, Zamboni WC, DeSimone JM, Yeh JJ.

Stromal Content Is Correlated With Tissue Site, Contrast Retention, and Survival in Pancreatic Adenocarcinoma. JCO Precision Oncology. 2018 Jan 16.

  • Torphy RJ, Wang Z, True-Yasaki A, Volmar KE, Rashid N, Yeh B, Johansen JS, Hollingsworth MA, Yeh JJ, Collisson EA.

Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer – Early Results from the COMPASS Trial. Clinical Cancer Research. 2017 Dec 29. Epub ahead of print.

  • Aung KL, Fischer SE, Denroche RE, Jang GH, Dodd A, Creighton S, Southwood B, Liang SB, Chadwick D, Zhang A, O’Kane GM, Albaba HAA, Moura S, Grant RC, Miller JK, Mbabaali F, Pasternack D, Lungu IM, Bartlett JMS, Ghai S, Lemire M, Holter S, Connor AA, Moffitt RA, Yeh JJ, Timms L, Krzyzanowski PM, Dhani NC, Hedley DW, Notta F, Wilson JM, Moore MJ, Gallinger S, Knox JJ.

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2017 Aug 14;32(2):185-203.e13. doi: 10.1016/j.ccell.2017.07.007.

  •  Cancer Genome Atlas Research Network (Yeh JJ)

Dual selection with discrete microfluidics for isolation of orthogonal subpopulations of circulating tumor cells. Nature Partner Journal Precision Oncology. 2017 Jul 25.

  • Witek MA, Auffort RD, Wang H, Kamande JW, Jackson JM, Pullagurla SW, Hupert ML, Usary J, Wysham WZ, Hilliard D, Montgomery S, Bae-Jump V, Carey LA, GehrigPA, Milowsky MI, Perou CM, Soper JT, Whang YE, Yeh JJ*, Martin G*, Soper SA*.
  • *co-corresponding

Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instabilityPLoS One. 2017 Apr 5; 12(4):e0174863.

  • Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ.

Selective single cell isolation for genomics using microraft arrays. Nucleic Acids Research. 2016 44(17):8292.

  • Welch JD, Williams LA, DiSalvo M, Brandt AT, Marayati R, Sims CE, Allbritton NL, Prins JF, Yeh JJ*, Jones CD*.
  • *co-corresponding

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production. Oncotarget. 2016 Jun 1;8(34):56081-56094.

  • Anderson M, Marayati R, Moffitt RA, Yeh JJ.

Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci USA. 2016 Feb 8. pii: 201600421

  • Byrne JD, Jajja MR, O’Neill AT, Schorzman AN, Keeler AW, Luft JC, Zamboni WC, DeSimone J*, Yeh JJ*.
  • *co-corresponding

Metformin treatment does not inhibit growth of pancreatic cancer patient-derived xenografts. PLoS One. 2016 Jan 13;11(1):e0147113.

  • Lipner MB, Marayati R, Deng Y, Wang X, Raftery L, O’Neil BH, Yeh JJ.

Long-term ERK inhibition in KRAS-mutant pancreatic cancer is associated with MYC degradation and senescence-like growth suppression. Cancer Cell. 2016 Jan; 29:1-15.

  • Hayes TK, Neel NF, Hu C, Gautam P, Chenard M, Long B, Aziz M, Kassner M, Bryant KL, Pierobon M, Marayati R, Kher S, George SD, Petricoin III, EF, Yin HH, Nelkin B, Cox AD, Yeh JJ, Der CJ.

Virtual microdissection of pancreatic ductal adenocarcinoma reveals tumor and stroma subtypes. Nature Genetics. 2015 Oct;47(10):1168-78

  • Moffitt RA, Marayati R, Volmar KE, Hoadley, KA, Anderson J, Bentrem DJ, Talamonti MS, Iacobuzio-Donahue CA, Hollingsworth MA, Yeh JJ.

Local Iontophoretic Administration of Cytotoxic Therapies to Solid Tumors. Sci Transl Med. 2015 Feb 4;7(273):273ra14

  • Byrne JD, Jajja MR, O’Neill AT, Bickford LR, Keller AW, Hyder N, Wagner K, Deal AM, Little RE, Moffit RM, Stack C, Nelson M, Brooks CR, Lee W, Luft JC, Napier ME, Darr D, Anders CK, Stack RS, Tepper J, Wang AZ, Zamboni WC, Yeh JJ*, DeSimone J*.
  • *co-corresponding

KRAS and PIK3CA mutation frequencies in patient derived xenograft (PDX) models of pancreatic and colorectal cancer are reflective of patient tumors and stable across passages. American Surgeon. 2014 Sep;80(9):873-7.

  • Tignanelli CJ, Herrera Loeza SG, Yeh JJ.

Small sample sorting of primary adherent cells by automated micropallet imaging and release. Cytometry A. 2014 Jul;85(7):642-9.

  • Shah PK, Herrera-Loeza SG, Sims CE, Yeh JJ, Allbritton NL.

Measurement of Protein Kinase B Activity in Single Primary Human Pancreatic Cancer Cells. Analytical Chemistry2014 May 6; 86(9):4573-80.

  • Proctor A, Herrera-Loeza SG, Wang Q, Lawrence D, Yeh JJ, Allbritton, NL.

Circulating Tumor Cells as a Biomarker of Response to Treatment in Patient-Derived Xenograft Mouse Models of Pancreatic Adenocarcinoma. PLoS One. 2014 Feb 19; 9)2:389474.

  • Torphy RJ, Tigananelli CJ, Kamande JW, Moffitt RA, Herrera Loeza SG, Soper SA, Yeh JJ.

Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma. Biosensors and Bioelectronics. 2014 Apr 15;54:476-83.

  • Gach PC, Attayek PJ, Whittlesey RL, Yeh JJ, Allbritton NL.

Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation. Molecular Cancer Therapy. 2014 Jan;13(1):122-33.

  • Neel NF, Stratford JK, Shinde V, Ecsedy JA, Martin TD, Der CJ, Yeh JJ.

UV activation of polymeric high aspect ratiomicrostructures: ramifications in antibody surface loading for circulating tumor cell selection. Lab Chip. 2014 Jan 7;14(1):106-17.

  • Jackson JM, Witek MA, Hupert ML, Brady C, Pullagurla S, Kamande J, Aufforth RD, Tignanelli CJ, Torphy RJ, Yeh JJ, Soper SA.

Isolation and in vitro culture of rare cancer stem cells from patient-derived xenografts of pancreatic ductal adenocarcinoma. Analytical Chemistry. 2013 Aug 6;85(15):7271-8.

  • Gach PC, Attayek PJ, Herrera G, Yeh JJ, Allbritton NL.

GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of non-canonical NF-κB. Cancer Discov. 2013 Jun 3(6):690-703.

  • Bang D, Wilson W, Ryan M, Yeh JJ, Baldwin AS.

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood. 2012 Jun 119(23):5543-52.

  • Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N.

Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. PLoS One. 2012 Mar;7(3):e32996.

  • Chaika NV, Yu F, Purohit V, Mehla K, Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR, Hollingsworth MA, Singh PK.

The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Molecular Cell Biology. 2012 Apr; 32(8):1374-86.

  • Neel NF, Rossman KL, Martin TD, Hayes TK, Yeh JJ, Der CJ.

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis. 2011 Apr;32(4):488-95.

  • Xu D, Allsop SA, Witherspoon SM, Snider JL, Yeh JJ, Fiordalisi JJ, White CD, Williams D, Cox AD, Baines AT.

A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med. 2010 Jul 13;7(7):e1000307. doi: 10.1371/journal.pmed.1000307. PMID: 20644708

  • Stratford JK, Bentrem DJ, Anderson JM, Fan C, Volmar KA, Marron JS, Routh ED, Caskey LS, Samuel JC, Der CJ, Thorne LB, Calvo BF, Kim HJ, Talamonti MS, Iacobuzio-Donahue CA, Hollingsworth MA, Perou CM, Yeh JJ.

Isoform-specific upregualtion of palladin in human and murine pancreas tumors. PLoS One. 2010 April 26;5(4):e10347.

  • Goicoechea SM, Bednarski B, Stack C, Cowan DW, Volmar K, Thorne L, Cukierman E, Rustgi AK, Brentnall T, Hwang RF, McCulloch CA, Yeh JJ, Bentrem DJ, Hochwald S, Hingorani SR, Kim HJ, Otey CA.