Chromatin remodeling (led by Dr. Weissman)- Sequencing efforts have similarly identified common mutations in the complex of proteins that influence the organization of chromatin. Dr. Weissman will review the discovery of chromatin as a platform for nuclear processes and the identification of chromatin remodeling complexes, their influences on chromatin, and the effect of subunit mutations … Read more

Histone variants and post-translational modifications (led by Dr. Strahl)- Mutations in histone-modifying enzymes and in histones themselves have been identified in a growing range of tumors. Dr. Strahl will cover histone modifications, alternative histones and the means by which they are regulated, and how they regulate various nuclear processes, including transcription and DNA damage repair. … Read more

Environmental epigenetics and cancer (led by Dr. Fry)- Compounds that modify the epigenome pervade our environment and may lead to transgenerational effects on cancer development. Dr. Fry will describe how the link between environmental factors and cancer evolved and how they may influence the epigenome.

High-throughput genomic approaches to study chromatin organization (led by Dr. Dowen)- Whole genome approaches to explore chromatin organization have shed light on new levels of gene regulation. Dr. Dowen will highlight the evolving methods to study genome organization and the way that these data can be integrated with other assays of nuclear function, such as … Read more