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We used a networks-based approach to identify DNA damage repair (DDR) genes not associated with TMB yet predictive of immune checkpoint response. The cover depicts a bipartite network of a subset of TCGA samples (blue pentagons, top) and DDR genes (circular nodes, bottom) colored according to DDR pathway membership. Edges link a sample to a mutated gene. A similar (though magnitudes larger) bipartite network was used to derive each gene’s BiG-BET score.