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UNC Lineberger Comprehensive Cancer Center

Publications

View complete list of publications in NCBl library

  • Baslan T*, Morris JP 4th*, Zhao Z, Reyes J, Ho YJ, Tsanov KM, Bermeo J, Tian S, Zhang S, Askan G, Yavas A, Lecomte N, Erakky A, Varghese AM, Zhang A, Kendall J, Ghiban E, Chorbadjiev L, Wu J, Dimitrova N, Chadalavada K, Nanjangud GJ, Bandlamudi C, Gong Y, Donoghue MTA, Socci ND, Krasnitz A, Notta F, Leach SD, Iacobuzio-Donahue CA, Lowe SW. Ordered and deterministic cancer genome evolution after p53 loss. Nature. 2022 Aug;608(7924):795-802. PMID: 35978189; PMCID: PMC9402436. *Equal contribution.
  • Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O’Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW. A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2110557119. PMID: 35442775; PMCID: PMC9169916.
  • Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW. A gene-environment-induced epigenetic program initiates tumorigenesis. Nature. 2021 Feb 3. doi: 10.1038/s41586-020-03147-x. Epub ahead of print. PMID: 33536616.
  • Ruscetti M*, Morris JP 4th*, Mezzadra R*, Russell J, Leibold J, Romesser PB, Simon J, Kulick A, Ho Y, Fennell M, Li J, Norgard RJ, Wilkinson JE, Alonso-Curbelo D, Sridharan R, Heller DA, de Stanchina E, Stanger BZ, Sherr CJ, and Lowe SW. ­­­Senescence triggers vascular remodeling and new therapeutic vulnerabilities in pancreas cancer. Cell. 2020;181(2):424‐441.e21. *Equal contribution
  • Chen CC, Li B, Millman SE, Chen C, Li X, Morris JP 4th, Mayle A, Ho YJ, Loizou E, Liu H, Qin W, Shah H, Violante S, Cross JR, Lowe SW, Zhang L. Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7. doi: 10.1016/j.ccell.2019.12.002. PMID: 31935373; PMCID: PMC7197326.
  • Escobar-Hoyos, LF, Penson, A, Kannan, R, Cho, H, Pan, C-H, Singh, RK, Hobbs, GA, Luo, R, Lecomte, N., Babu, S., Pan, F. C., Alonso-Curbelo, D., Morris JP 4th., Askan, G, Grbovic-Huezo, O, Ogrodowski, P, Bermeo, J, Saglimbeni, J, Cruz, C. D, Ho, Y-J, Lawrence, S. A, Melchor, J. P, Goda, G. A, Bai, K, Pastore, A, Hogg, S. J, Raghavan, S, Bailey, P, Chang, D. K, Biankin, Shroyer, KR, Wolpin, BM, Aguirre, AJ, Ventura, A, Taylor, B, Der, CJ, Dominguez, D, Kümmel, D, Oeckinghaus, A, Lowe, S, Bradley, R, Abdel-Wahab, O, and Leach, SD. Altered RNA splicing by mutant p53 activates oncogenic RAS signaling in pancreatic cancer. In press. Cancer Cell
  • Morris JP 4th, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS, and Lowe SW. Alpha-ketoglutarate links p53 to cell fate during tumor suppression. Nature. 2019;573(7775):595‐599.
  • Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP 4th, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D’Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2018 Dec 14. pii: S0092-8674(18)31503-4.
  • Livshits G, Alonso-Curbelo D, Morris JP 4th, Koche R, Saborowski M, Wilkinson JE, Lowe SW. Arid1a restrains Kras-dependent changes in acinar cell identity. Elife. 2018 Jul 17;7. pii: e35216. doi: 10.7554/eLife.35216.
  • Manchado E, Weissmueller S, Morris JP 4th, Chen CC, Wullenkord R, Lujambio A, de Stanchina E, Poirier JT, Gainor JF, Corcoran RB, Engelman JA, Rudin CM, Rosen N, Lowe SW. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016. 534:647-51.
  • Morris JP 4th, Greer R, Russ HA, von Figura G, Kim GE, Busch A, Lee J, Hertel KJ, Kim S, McManus M, Hebrok M. Dicer regulates differentiation and viability during mouse pancreatic cancer initiation. PLoS One. 2014. 9:e95486.
  • von Figura G, Fukuda A, Roy N, Liku ME, Morris JP 4th, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014. 16:255-67.
  • Weissmueller S, Manchado E, Saborowski M, Morris JP 4th, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, Grimmond SM, Pilarsky C, Prives C, Biankin AV, Lowe SW. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Cell. 2014. 157:382-94.
  • Saborowski M, Saborowski A, Morris JP 4th, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW. A modular and flexible ESC-based mouse model of pancreatic cancer. Genes and Development. 2014. 28:85-97.
  • von Figura G, Morris JP 4th, Wright CV, Hebrok M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut. 2014. 63:656-64. 17. Chen C, Liu Y, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes and Development. 2013. 27:1974-85.
  • Zhang Y, Morris JP 4th, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis. Cancer Research. 2013. 73:4909-4922.
  • Lin WC, Rajbhandari N, Liu C, Sakamoto K, Zhang Q, Triplett AA, Batra SK, Opavsky R, Felsher DW, DiMaio DJ, Hollingsworth MA, Morris JP 4th, Hebrok M, Witkiewicz AK, Brody JR, Rui H, Wagner KU. Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Research. 2013. 73:1821-30.
  • Kopp JL, von Figura G, Mayes E, Liu F, Dubois CL, Morris JP 4th, Cheng Pan F, Akiyama H, Wright CVE, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012. 22:737-50.
  • Fukuda A, Morris JP 4th, Hebrok M. Bmi1 is required for regeneration of the exocrine pancreas in mice. Gastroenterology. 2012. 143:821-31.e1-2.
  • Fukuda A, Wang SC, Morris JP 4th, Folias AF, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M. Stat3 and MMP7 Contribute to Pancreatic Cancer Initiation and Progression. Cancer Cell. 2011. 19:441-55.
  • Morris JP 4th, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 2010. 10:683-95.
  • Morris JP 4th, Cano DA, Sekine S, Wang SC, Hebrok M. b-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest. 2010. 120:508-20
  • Morris JP 4th, Hebrok M. It’s a free for all–insulin-positive cells join the group of potential progenitors for pancreatic ductal adenocarcinoma. Cancer Cell. 2009. 16:359-61.
  • Tan GS, Garchow BG, Liu X, Yeung J, Morris JP 4th, Cuellar TL, McManus MT, Kiriakidou M. Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res. 2009. 37:7533-45.
  • Morton JP, Mongeau ME, Klimstra DS, Morris JP 4th, Lee YC, Kawaguchi Y, Wright CV, Hebrok M, Lewis BC. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 2007. 104:5103-8.
  • Morris JP 4th, McManus MT. Slowing down the Ras lane: miRNAs as tumor suppressors? Sci STKE. 2005 Aug 16;2005(297):pe41
  • Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP 4th, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A. 2005. 102:407-12.
  • Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004. 306:269-71.
  • Berghmans S, Morris JP 4th, Kanki JP, Look AT. Zebrafish sperm cryopreservation. Methods Cell Biol. 2004. 77:645-59.
  • Morris JP 4th, Berghmans S, Zahrieh D, Neuberg DS, Kanki JP, Look AT. Zebrafish sperm cryopreservation with N,N-dimethylacetamide. Biotechniques. 2003. 35:956-8, 960, 962 passim.
  • Butler JP, Brown RE, Stamenovic D, Morris JP IV, Topulos GP. Effect of surface tension on alveolarsurface area. J Appl Physiol. 2002. 93:1015-22