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UNC Lineberger Comprehensive Cancer Center

Publications

T cell differentiation

Chung, H. K.*, Cong, L.*, … Wang, Y., Hargreaves, D., Wang, W., Kaech, S. M. Multiomics atlas-assisted discovery of transcription factors enables specific cell state programming. bioRxiv (2023).

Kasmani, M. Y*., Zander, R*., Chung, H. K., … Kaech, S. M., Cui, W. Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions during chronic viral infection. Journal of Experimental Medicine 220 (1), e20220679 (2022) *Equal contribution.

Chung, H. K., B. McDonald, S.M. Kaech. The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates. Journal of Experimental Medicine 218, 1–15 (2021).

Synthetic toolkit development

Chung, H. K., Lin, M. Z. On the cutting edge: protease-based methods for sensing and controlling cell biology. Nature Methods, (2020).

Chung, H. K., Zou, X., Bajar, B. T., Brand, V. R., Huo, Y., Alcudia, J. F., Ferrell, J. E., Lin, M. Z. A compact synthetic pathway rewires cancer signaling to therapeutic effector release. Science 364, eaat6982 (2019).

Zhou, X. X., Zou X., Chung, H. K., Gao, Y., Liu, Y., Qi, S. L., Lin, M.Z. A single-chain photoswitchable Cas9 architecture for inducible gene editing and transcription. ACS Chemical Biology 13, 443-448 (2018).

Chung, H. K., Jacobs, C. L., Huo, Y., Yang, J., Krumm, S. A., Plemper, R. K., Tsien, R. Y., Lin, M. Z. Tunable and reversible drug control of protein production via a self-excising degron. Nature Chemical Biology 11, 713–720 (2015).

Zhou, X. X., Chung, H. K., Lam, A. J., Lin, M. Z. Optical control of protein activity by fluorescent protein domains. Science 338, 810–814 (2012).

Oncolytic virus engineering

Chung, H. K., Jacobs, C. L., Huo, Y., Yang, J., Krumm, S. A., Plemper, R. K., Tsien, R. Y., Lin, M. Z. Tunable and reversible drug control of protein production via a self-excising degron. Nature Chemical Biology 11, 713–720 (2015).

Yan, D., Weisshaar, M., Lamb, K., Chung, H. K., Lin, M. Z., Plemper, R. K. Replication-competent Influenza virus and Respiratory Syncytial virus luciferase reporter strains engineered for co-infections identify antiviral compounds in combination screens. Biochemistry 54, 5589-604 (2015).