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Recent Publications

Nicholls, TJ., Nadalutti, CA., Motori, E., Sommerville, EW., Gorman, GS., Basu, S., Hoberg, E., Turnbull, DM., Chinnery, PF., Larsson, NG., Falkenberg, M., Taylor, RW., Griffith, JD., and Gustafsson, CM. (2018) Topoisomerase 3a is Required for Decatenation and Segregation of Human mtDNA. Mol. Cell., 69:(1): 9-23.e6 PN+MID 29290614

Ciesielski, GL., Nadalutti, CA., Olivera, MT., Jacobs, HT., Griffith, JD, and Kaguni, LS. (2018). Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase. Nucleic Acids Res. Apr 6;46(6):3034-3046. doi: 10.1093/nar/gky094 PMID: 29432582

McNamara, R., Costantini, L., Meyers, Schoust, B., Maness, N., Griffith, JD., Damania, B., MacLean, A., and Dittmer, D. (2018) Nef secretion into Extracellular Vesicles or exosomes is conserved across human and simian immunodeficiency viruses. MBio. Feb 6;9(1). pii: e02344-17. doi: 10.1128/mBio.02344-17 PMID: 29437924

Amunugama, R,, Willcox, S., Wu, RA., Abdullah, UB., El-Sagheer, AH., Brown, T., McHugh, PJ., Griffith, JD.,  and  Walter JC. (2018). Replication Fork Reversal During DNA Interstrand Crosslink Repair Requires CMG Unloading.  Cell Reports.  Jun 19;23(12) doi: 10.1016j.celrep. 2018.05.0613419-3428. PMID 29924986

Kar, A., Jones, N., Arat, N-O., Fishel, R., and Griffith, JD. (2018). Long repeating (TTAGGG)n single stranded DNA self-condenses into compact beaded filaments stabilized by G-quadruplex formation. J. Biol. Chem. 2018 Jun 15;293(24):9473-9485. doi: 10.1074/jbc.RA118.002158. Epub 2018 Apr 19. PMID: 29674319

Zhu, C., Beck, M.C., Griffith, J.D., Deshmukh, M., and Dokholyan, N.V. (2018). Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci.USA. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4661-4665. doi: 10.1073/pnas.1800187115. Epub 2018 Apr 16.PMID: 29666246

McNamara RP, Caro-Vegas CP, Costantini LM, Landis JT, Griffith JD, Damania BA, Dittmer DP. (2018). Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles. J Extracell Vesicles. 2018 Nov 30;7(1):1541396. doi: 10.1080/20013078.2018.1541396. eCollection PMID: 30533204

Tomáška L, Nosek J, Sepšiová R, Cervenák F, Juríková K, Procházková K, Nebohácová M, Willcox S, Griffith JD. (2019). Commentary: Single-stranded telomere-binding proteins employs a dual rheostat for binding affinity and specificity that drives function. Front Genet. 2019 Jan 15;9:742. doi: 10.3389/fgene.2018.00742. eCollection 2018.

McNamara RP, Chugh PE, Bailey A, Costantini LM, Ma Z, Bigi R, Cheves A, Eason AB, Landis JT, Host KM, Xiong J, Griffith JD, Damania B, Dittmer DP.  (2019) Extracellular vesicles from Kaposi Sarcoma-associated herpesvireus lymphoma induce long-term endothelial cell reprogramming. PLoS Pathog. Feb 4;15(2):e1007536. doi: 10.1371/journal.ppat.1007536. eCollection 2019 Feb.

Tomaska L, Nosek J, Kar A, Willcox S, Griffith JD. (2019). A new view of the T-loop Junction: Implications for Self-Primed Telomere Extension, Expansion of Disease-Related Nucleotide Repeat Blocks and Telomere Evolution. Front Genet. 2019 Aug 14;10:792. doi: 10.3389/fgene.2019.00792. eCollection 2019.PMID: 31475042

Krokhotin A, Sarker M, Sevilla EA, Costantini LM, Griffith JD, Campbell SL, Dokholyan NV. Structure. (2019). Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences. Oct 1;27(10):1527-1536. PMID:31422909

Sarker M, Lee HT, Mei L, Krokhotin A, de Los Reyes SE, Yen L, Costantini LM, Griffith J, Dokholyan NV, Alushin GM, Campbell SL. (2019) Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies.  J Mol Biol. Apr 5;431(8):1604-1618. PMID: 30844403

Nadalutti CA, Stefanick DF, Zhao ML, Horton JK, Prasad R, Brooks AM, Griffith JD, and Wilson SH. (2020). Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts. Sci Rep. 2020 Mar 27;10(1):5575. doi: 10.1038/s41598-020-61477-2 PMID:32221313

Tsutakawa, S. E., Sarker, A. H., Ng, C., Arvai, A. S., Shin, D. S., Shih, B., Jiang, S., Thwin, A. C., Tsai, M. S., Willcox, A., Her, M. Z., Trego, K. S., Raetz, A. G., Rosenberg, D., Bacolla, A., Hammel, M., Griffith, J. D., Cooper, P. K., & Tainer, J. A. (2020). Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutationsProc Natl Acad Sci U S A, 117(25), 14127-14138. doi:10.1073/pnas.1921311117. PMC7321962. 04-VIR

Griffith, J.D. (2020). Electron microscopic characterization of exhaust particles containing lead dibromide beads expelled from aircraft burning leaded gasoline. Atmospheric Pollution Research. vol. 11 #9 1481-1486

Tomáška Ľ, Cesare AJ, Al-Turki TM, and Griffith JD. (2020) Twenty years of t-loops: A case study for the importance of collaboration in molecular biology. DNA Repair (Amst). Jun 26:102901. doi: 10.1016/j.dnarep.2020.102901. PMID: 32620538