Recent News

Study sheds light on why some breast cancers have limited response to immunotherapy

Study sheds light on why some breast cancers have limited response to immunotherapy

Jonathan Serody, MD, Benjamin Vincent, MD, and a team of UNC Lineberger investigators published findings in the Journal of Clinical Investigation that may explain why drugs designed to unleash the immune system against cancer were ineffective in treating a type of triple negative breast cancer. They determined “claudin-low” tumors were releasing a chemical signal to attract regulatory T-cells, which prevented the immune system from rejecting the cancer.

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 Researchers find genetic precursors of leukemia in cancer patients

Researchers find genetic precursors of leukemia in cancer patients

A study led by UNC Lineberger's Catherine Coombs, MD, revealed new risk factors for “clonal hematopoiesis,” a medical phenomenon in which genetic mutations are found in the blood cells of patients who do not have an existing blood cancer.

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Researchers look to improve detection of skin cancer lacking pigment melanin

Researchers look to improve detection of skin cancer lacking pigment melanin

UNC Lineberger researchers led by Nancy Thomas, MD, PhD, have identified key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin.

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Aggressive breast cancers may contribute to racial survival disparities

Aggressive breast cancers may contribute to racial survival disparities

In the Journal of the National Cancer Institute, UNC Lineberger researchers led by Melissa Troester, PhD, published results of an analysis of approximately 1,000 invasive breast tumors. The study confirmed that young black women are more likely to have “triple negative,” or “basal-like,” breast cancers, a subtype that does not express any of the receptors for targeted biologic therapies. The study also identified variation by race within a clinical breast cancer type that has the greatest mortality disparity.

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