Abstract submission closed on Nov. 15, 2019

The event will be held Thursday, Dec. 5, 2019, 11:30 a.m. – 6:30 p.m. at the Medical Biomolecular Research Building, G-202.

Sponsors

Jointly sponsored by the Carolina Chromatin Consortium, Cancer Epigenetics Training Program, IBGS, NIEHS, and Lineberger Comprehensive Cancer Center.

Symposium Keynote Speaker

Danesh Moazed headshotDanesh Moazed, PhD
Professor, Department of Cell Biology
Investigator, Howard Hughes Medical Institute
Harvard Medical School

“Epigenetic Inheritance: Beyond DNA and Back”

Danesh Moazed is currently a Professor in the Department of Cell Biology at Harvard Medical School and an Investigator of the Howard Hughes Medical Institute. He received his B.A. and Ph.D. degrees from the University of California in Santa Cruz working with Harry F. Noller on the roles of ribosomal RNAs in protein synthesis. He performed postdoctoral research at the University of California in San Francisco with Patrick O’Farrell and Alexander Johnson. His group is interested in understanding how genes are silenced and how gene silencing can be stably inherited during cell division and across generations.

Agenda

Time

Event

11:30 a.m. – 12:00 p.m. Lunch – Pizza lunch in the MBRB Lobby
12:15 p.m. Opening Remarks – Bernard Weissman, PhD

Session 1: Chair Joseph Rodriguez, PhD

12:20 – 12:40 p.m. Amanda Conway, PhD – Jothi Lab – NIEHS A Non-Canonical Role for Nuclear Export Protein Crm1 in the Establishment of PRC2-mediated Gene Silencing
12:40 – 1:00 p.m. Gabrielle Dardis – Baldwin Lab – EZH2 as a Transcriptional Activator of NF-κB Target Genes in TNBC
1:00 – 2:00 p.m. Keynote: Danesh Moazed, PhD – Epigenetic Inheritance: Beyond DNA and Back
2:00 – 2:20 p.m. Break

Session 2: Chair Jill Dowen, PhD

2:20 – 2:40 p.m. Yi Fang, PhD – Li Lab – NIEHS Histone crotonylation promotes endodermal commitment of pluripotent embryonic stem cells
2:40 – 3:00 p.m. Kanishk Jain, PhD – Strahl Lab – Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
3:00 – 3:20 p.m. Dongbo Lu – Hathaway Lab – Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery
3:20 – 3:40 p.m. Frances Potjewyd, PhD – Frye Lab – Degradation of Polycomb Repressive Complex 2 Components with an EEDtargeted Bivalent Chemical Degrader
3:40 – 4:00 p.m. Jackson Trotman, PhD – Calabrese Lab – Determining how Xist Repeat A initiates gene silencing
4:00 – 4:20 p.m. Tamara Vital – Davis Lab – Characterizing a small molecule inhibitor of chromatin accessibility in Ewing sarcoma
4:20 – 4:40 p.m. Tara Walhart, PhD, NP-C, MPH – Weissman Lab – Identifying How SMARCB1 Loss Drives De-differentiated Chordoma Development
4:45 – 6:15 p.m. Poster Session and Cocktail Reception – Second Floor Atrium