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Elizabeth Brunk, PhD, is a UNC Lineberger Comprehensive Cancer Center member, genomicist and systems biologist studying the functional impacts of chromosomal aberrations called extrachromosomal DNA (ecDNA).

PhD
Assistant Professor, Pharmacology and Chemistry
UNC-Chapel Hill
Cancer Cell Biology

Area of Interest

I am a genomicist and systems biologist studying the functional impacts of chromosomal aberrations called extrachromosomal DNA (ecDNA). The focus of my research is on developing computational and experimental methods that accelerate the identification of ecDNA, characterize relationships between its structure and function and discover new strategies for targeting.

My laboratory integrates various techniques and technologies to study the mechanistic basis of the asymmetric division of ecDNA into daughter cells and the universal relationships between cell population heterogeneity in ecDNA and proliferation, fitness and drug resistance. I approach these topics through the lens of computational biology, machine learning and multi-omics data science.

A growing body of work in the biomedical sciences characterizes the clinical impacts of ecDNA in cancer; my work contributes to these efforts by focusing on fundamental biological roles of ecDNA and its impacts on cellular functioning and adaptation.

Find publications on PubMed

Headshot of Elizabeth Brunk.