Professor and Chair, Department of Pharmacology
Area of Interest
As a translational basic scientist, my research interests focus on understanding the behavior of the kinome en masse in cancer. My laboratory has developed chemical proteomics methods that allows measurement of the functional state of ~90% of the kinome that can be applied to cell lines, preclinical animal models, patient-derived xenografts and clinical trials. My laboratory integrates kinome proteomics with next generation sequencing and chromatin epigenetics to define the dynamic behavior and function of the kinome at both baseline and with perturbation. Our focus is on defining mechanisms of resistance to targeted kinase inhibitors.
Awards and Honors
- Battle Award for Cancer Research