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Kenan Distinguished Professor
Professor, Department of Biochemistry and Biophysics
UNC-Chapel Hill
Molecular Therapeutics

Area of Interest

We use the formalism of equilibrium thermodynamics and the tools of molecular biology and biophysics to understand how nature designs proteins. Our research focuses on several cancer-related proteins including apaf-1, a protein that is key to apoptosis, and natively disordered proteins, a new class of proteins whose members control cellular signaling and regulation. We bring to bear techniques such as random- and directed-mutagenesis, circular dichroism spectropolarimetry, differential scanning calorimetry, isothermal titration calorimetry, analytical ultracentrifugation, mass pectrometry, and nuclear magnetic resonance spectroscopy.

Awards and Honors

  • Elected co-chair of the 2007 Proteins Gordon Research Conference
  • Elected co-vice chair of the 2005 Proteins Gordon Research Conference
  • Underhill Fund Award (BBSRC, U.K.)
  • Invited Speaker, Proteins Gordon Conference, 2001
  • Invited Speaker, Biopolymers Gordon Conference, 2002
  • Invited Speaker, RASMB Gordon Conference, 2002
  • Invited Speaker FASEB Meeting: Protein Folding in the Cell, 2002
  • Invited Speaker 13th Conversations in Biomolecularstereodynamics, 2003

Find publications on PubMed

  • Phone Number

    (919) 962-4495 (Office Phone)

  • Address

    Department of Chemistry

    3250 Genome Sciences Building

    CB# 3290

    Chapel Hill, NC 27599-3290