MD, PhD
Stuart H. Gold Distinguished Professor
Co-Leader, UNC Lineberger Cancer Genetics Research Program
Chief, Division of Pediatric Hematology-Oncology
Associate Director, Cancer Epigenetics Training Program
UNC-Chapel Hill
Cancer Genetics
Area of Interest
I am interested in the application of integrated genome-wide approaches to identify the epigenetic and chromatin biology consequences of genetic alterations in human cancers. Primary foci of the lab include Ewing sarcoma in which we explore the mechanism through which the necessary chromosomal translocation-derived fusion oncoprotein EWSR1-FLI1 regulates chromatin states and target genes. We also are evaluating the effect of mutations in the histone methyltransferase SETD2 and the chromatin remodeling complex member PBRM1 in clear cell renal cell carcinoma. Because of our expertise in epigenomics, we also collaborate with labs across the campus studying other cancers and developmental disorders.
Awards and Honors
- Dick Vitale Pediatric Cancer Research Fund, The V Foundation, 2023
- G. Denman Hammond Professorship for Childhood Cancer
- Martin D. Abeloff V Scholar Award
- Rita Allen Foundation Scholar
News and Stories
Pediatric care partners help improve the outpatient experience
At the Reelin’ for Research Pediatric Hematology-Oncology Clinic, a key addition made to the outpatient care team has improved patient care, trust and clinic efficiency.
Immune cell transformation can influence stem cell transplant success in cancer patients
Jonathan Serody, MD, Ian Davis, MD, PhD, and colleagues report ILC2s can change functions after a patient receives stem cells, thereby preventing a healthy rebuilding of the immune system.
