MD
Professor, Medicine-Oncology
Associate Director for Finance, UNC Lineberger Clinical Protocol Office
UNC-Chapel Hill
Clinical Research
Thoracic Oncology Program
Meet Jared Weiss
Area of Interest
My primary focus is on personalized immunotherapy for lung cancer and for head/neck cancer. At the current time, my primary effort is PANDA-VAC, a personalized and adaptive vaccine generated from prediction of Neo-antigens (LCCC1804). I am also in the early stages of cellular therapeutics work targeting GD2 and MAGE-A4 and in very early work on a novel mechanism for better selection of TIL (tumor infiltrating lymphocytes) products.
I am the national PI for investigator-initiated trials evaluating the introduction of oncolytic virus into malignant pleural effusions (LCCC1626), induction chemo-immunotherapy in locally advanced, surgically resectable head and neck cancer (LCCC1621), and adjuvant immune-radiotherapy in head/neck cancer (LCCC1725). A funded effort to evaluate LXR/ApoE agonism to reduce MDSCs (LCCC1925) is funded and in the protocol writing stage.
I also lead and participate in several international industry efforts; key amongst these is ILIAD (IM-202, ilixadencel dendritic cell infusion into solid tumors). Other efforts include immunolight, LOXO-292 (RET inhibitor) and trilacyclib (CDK4/6 inhibitor for myelopreservation in SCLC, manuscript under minor revisions at Annals of Oncology).
Awards and Honors
- Jimmy V Foundation Translational/Clinical Award, 2018-2020
- UNC Seq V2 award, 2018-2021
News and Stories
Clinical trial improves man’s quality of life with tongue cancer
Vance Aldrich Bell III experienced positive life-changing results after participating in a clinical trial for squamous cell carcinoma of the tongue.
Is it cancer? Only your doctor can tell you for sure
Many benign conditions can mimic the symptoms of cancer. But only your doctor can tell you for sure what’s going on—diagnosing yourself on the internet won’t help.
She was 39, never smoked and diagnosed with lung cancer
Walthall was 39 years old and had never smoked. No one suspected lung cancer, and she had no family history of the disease. But in February, she was diagnosed with stage 4 lung cancer.
UNC Lineberger recognizes Lung Cancer Awareness Month in November
UNC Lineberger faculty and staff have been holding events throughout November to educate the community on the latest research and clinical advances in lung cancer.
