Associate Director School of Medicine
Cancer Cell Biology
Area of interest
My lab studies the role of ubiquitin signaling in cell cycle, genome stability and cancer. We are specifically interested in how these ubiquitin signaling networks contribute to breast and ovarian malignancy. A major focus is on mechanisms underlying cell cycle transitions, including exit from mitosis and entry into S-phase. Both are governed by the APC/C, an essential cell cycle E3 ubiquitin ligase that both promotes mitotic exit and restrains S-phase entry. We recently identified a deubiquitinase that antagonizes APC/C substrate degradation, and which is recurrently amplified in breast cancer. In addition, we have shown that APC/C can be further inactivated via the oncogenic PI3k-AKT signaling cascade. Ongoing studies to diagnostically map substrates using computational methods have revealed unforeseen contributions to cell physiology, and potential consequences of its dysfunction in disease.
- Emanuele MJ, Elia EH, Xu Q, Thoma CR, Izhar L, Guo A, Rush J, Hsu PW, Yen HS, Elledge SJ. Global Identification of Modular Cullin-Ring Ligase Substrates. Cell. 2011 Oct 14;147(2):459-74.
- Emanuele MJ, Ciccia A, Elia AE, Elledge SJ. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. PNAS 2011. 108 (24) 9845-9850.
- Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong K, Elledge SJ. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.Cell. 2009 May 29; 137(5). 835-48.
- Emanuele MJ, Lan W, Jwa M, Miller SA, Chan, CSM, Stukenberg PT. Aurora B kinase and Protein Phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol. 2008 Apr 21;181(2):241-54.
- Emanuele MJ and Stukenberg PT. Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell. 2007 Sep 7;130(5):893-905.
Awards and Honors
- Associate Professor with tenure, American Cancer Society Research Scholar Award