Michael James Emanuele

Michael Emanuele, PhD, is a UNC Lineberger Comprehensive Cancer Center member and Assistant Professor in the Department of Pharmacology at the UNC-Chapel Hill School of Medicine. Emanuele Lab have interest in cell cycle, mitosis, protein stability, ubiquitin, cancer, genetics and cell biology.

PhD
Associate Professor, Department of Pharmacology, Cancer Cell Biology Program
UNC-Chapel Hill

Area of interest

My lab studies the role of ubiquitin signaling in cell cycle, genome stability and cancer. We are specifically interested in how these ubiquitin signaling networks contribute to breast and ovarian malignancy. A major focus is on mechanisms underlying cell cycle transitions, including exit from mitosis and entry into S-phase. Both are governed by the APC/C, an essential cell cycle E3 ubiquitin ligase that both promotes mitotic exit and restrains S-phase entry. We recently identified a deubiquitinase that antagonizes APC/C substrate degradation, and which is recurrently amplified in breast cancer. In addition, we have shown that APC/C can be further inactivated via the oncogenic PI3k-AKT signaling cascade. Ongoing studies to diagnostically map substrates using computational methods have revealed unforeseen contributions to cell physiology, and potential consequences of its dysfunction in disease.

Selected Publications

  • Arceci A, Bonacci T, Wang X, Stewart K, Damrauer JS, Hoadley KA, Emanuele MJ. FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-Like Breast Cancer. Cell Reports. 2019 Mar 12;26(11):3076-3086.e6. PMID: 30865895
  • Bonacci T, Suzuki A, Grant G, Cook JG, Brown NG, Emanuele MJ. Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates. EMBO Journal.  2018 Jul 4. PMID: 29973362
  • Choudhury R, Bonacci T, Wang W, Truong A, Arceci A, Zhang Y, Mills, CA, Kernan JL, Liu P, Emanuele MJ. The E3 ubiquitin ligase SCF(Cyclin F) transmits AKT signaling to the cell cycle machinery. Cell Reports. 2017 Sep 26;20(13):3212-3222. PMID: 28954236
  • Wang X, Arceci A, Bird K, Mills CA, Choudhury R, Kernan JL, Zhou C, Bae-Jump V, Bowers A, Emanuele MJ. VprBP/DCAF1 regulates the degradation and non-proteolytic activation of the cell cycle transcription factor FoxM1. Molecular and Cellular Biology. 2017 Jun 15;37(13). PMID: 28416635
  • Choudhury C, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke D, Emanuele MJ. APC/C and SCF(cyclin F) constitute a reciprocal feedback circuit controlling S-phase entry. Cell Reports. 2016 Sep 20;16(12):3359-72. PMID: 27653696
  • Emanuele MJ, Elia EH, Xu Q, Thoma CR, Izhar L, Guo A, Rush J, Hsu PW, Yen HS, Elledge SJ. Global identification of modular cullin-RING ligase substrates. Cell. 2011 Oct 14;147(2):459-74. PMID: 21963094
  • Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong K, Elledge SJ. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell. 2009 May 29; 137(5). 835-48. PMID: 19490893
  • Emanuele MJ and Stukenberg PT.  Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell. 2007 Sep 7; 130(5):893-905. PMID: 17803911

Awards and Honors

  • Associate Professor with tenure, American Cancer Society Research Scholar Award
  • Susan G Komen Career Catalyst Research Award
  • Jimmy V Foundation-Scholar Award
  • Damon Runyon Postdoctoral Fellowship Award

Find publications on Pubmed

Michael Emanuele, PhD