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Michael Emanuele, PhD, is a UNC Lineberger Comprehensive Cancer Center member with research interests in how ubiquitin signaling networks contribute to breast and ovarian cancer.

PhD
Associate Professor, Pharmacology
UNC-Chapel Hill
Cancer Cell Biology Program

Area of Interest

My lab studies the role of ubiquitin signaling in cell cycle, genome stability and cancer. We are specifically interested in how these ubiquitin signaling networks contribute to breast and ovarian malignancy. A major focus is on mechanisms underlying cell cycle transitions, including exit from mitosis and entry into S-phase. Both are governed by the APC/C, an essential cell cycle E3 ubiquitin ligase that both promotes mitotic exit and restrains S-phase entry. We recently identified a deubiquitinase that antagonizes APC/C substrate degradation, and which is recurrently amplified in breast cancer. In addition, we have shown that APC/C can be further inactivated via the oncogenic PI3k-AKT signaling cascade. Ongoing studies to diagnostically map substrates using computational methods have revealed unforeseen contributions to cell physiology, and potential consequences of its dysfunction in disease.

Awards and Honors

  • Associate Professor with tenure, American Cancer Society Research Scholar Award
  • Susan G Komen Career Catalyst Research Award
  • Jimmy V Foundation-Scholar Award
  • Damon Runyon Postdoctoral Fellowship Award

Find publications on PubMed

Michael Emanuele, PhD