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Professor, Cell Biology and Physiology
UNC-Chapel Hill
Cancer Cell Biology

Area of Interest

Research in my lab is currently focused on five areas where a greater knowledge of basic cell biology can be applied towards overcoming clinical lung disease problems.

  1. Identification of Airway Epithelial Stem Cells: Our goals are to identify and isolate airway epithelial stem cells and to understand molecular mechanisms regulating airway epithelial cell proliferation and fate.
  2. Cell Therapy for Cystic Fibrosis (CF): As a member of the CF Foundation Stem Cell Consortium we are collaborating widely to help find cures for everyone with CF. Our particular focus is finding treatments for Class 1 CFTR variants, cell therapy, and in vivo gene editing.
  3. Innate Immunity in the Airway: Our goals are to better understand airway epithelial adaptation to chronic injury and infection and to understand the relationship of adaptation to the pathogenesis of airway disease.
  4. Inhalation Exposure Hazards: We are examining mechanisms of airway and lung injury relevant to inhalation exposure hazards, particularly burn pit emissions.
  5. UNC CF Center Tissue Procurement and Cell Culture Core: This Core provides primary and passaged human and animal lung cells, media and expertise to UNC CF Center investigators and collaborators. This facility is a nationally and internationally recognized resource whose services are sought for collaboration, contract research, and training by academics, non-profit organizations, biotech and the pharmaceutical industry. It has been particularly important for research on emerging pathogens and disease pathogenesis studies including H1N1, SARS CoV1, MERS and SARS CoV2/COVID-19.

Find publications on PubMed

Awards and Honors

  • Highly Cited Researchers (Top 1%), Web of Science, Clarivate Analytics, 2023

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Headshot of Scott Randell.