Immunology and Systems Biology
Area of interest
Dr. Chen is the director of Technology Development in the UNC Proteomics Center at the University of North Carolina – Chapel Hill and is a professor in the Department of Biochemistry and Biophysics. Dr. Chen’s research focuses on both the development and application of unconventional and transformative technology of systems biology, particularly mass spectrometry-based proteomics and multi-omics approaches, to elucidate the molecular mechanisms underlying pathogenesis of various human diseases such as cancer, Alzheimer’s disease and diabetes.
Dr. Chen’s lab invented amino acid-coded mass tagging (AACT) (a.k.a SILAC) that has unique strengths for comparative analysis of protein-protein interactions and post-translational protein modification. His lab is interested in a broad range of signaling and epigenetic regulatory pathways/mechanisms underlying exactly how tumor cells escape from immune surveillance, but not limited to the Toll-like receptor (TLR)-mediated pathways and DNA damage response pathways. Their ultimate goal is to mechanistically derive novel, precise disease markers for early diagnosis and therapeutic intervention.