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Xian Chen, PhD, is a UNC Lineberger Comprehensive Cancer Center member, Associate Professor of Biochemistry and Biophysics at UNC-Chapel Hill and Faculty Director for Quantitative Proteomics Center for Disease Markers. Chen Lab is focusing on developing and applying cutting-edge technologies of proteomics to investigate systematically the molecular pathways/mechanisms of real-time pathogenesis of various human diseases such as immune disorders, inflammation-associated cancers, etc.

Professor, Biochemistry and Biophysics
UNC-Chapel Hill

Area of Interest

Xian Chen, PhD, is the director of Technology Development in the UNC Proteomics Center at the University of North Carolina at Chapel Hill and is a professor in the Department of Biochemistry and Biophysics. Chen’s research focuses on both the development and application of unconventional and transformative technology of systems biology, particularly mass spectrometry-based proteomics and multi-omics approaches, to elucidate the molecular mechanisms underlying pathogenesis of various human diseases such as cancer, Alzheimer’s disease and diabetes.

Chen’s lab invented amino acid-coded mass tagging (AACT) (a.k.a SILAC) that has unique strengths for comparative analysis of protein-protein interactions and post-translational protein modification. His lab is interested in a broad range of signaling and epigenetic regulatory pathways/mechanisms underlying exactly how tumor cells escape from immune surveillance, but not limited to the Toll-like receptor (TLR)-mediated pathways and DNA damage response pathways. Their ultimate goal is to mechanistically derive novel, precise disease markers for early diagnosis and therapeutic intervention.

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