Associate Professor, Medicine-Oncology
Urologic Oncology Program
Meet Young Whang
Area of Interest
My laboratory is interested in characterizing the role of cytoplasmic signaling pathways in regulation of androgen receptor activity and progression of prostate cancer. Our studies have focused on HER-2 receptor tyrosine kinase and we have demonstrated that HER-2 activation stimulates androgen receptor activity and HER-2 inhibition inhibits androgen receptor transcriptional function at the level of recruitment to the androgen responsive enhancers. These findings have led to the design and initiation of the protocol involving lapatinib, a clinical HER-2 inhibitor, in treatment of patients with prostate cancer. More recently, we have demonstrated that activated Cdc42-associated kinase Ack1 promotes progression of prostate cancer via tyrosine phosphorylation of androgen receptor at Tyr-267 and Tyr-363 residues. We are interested in further characterizing the role of tyrosine phosphorylation of androgen receptor in prostate cancer and development of Ack1 targeted therapy for clinical use.
- We have shown that tyrosine kinases HER-2 and Ack1 regulate androgen receptor activity in prostate cancer cells and mapped phosphorylation sites in androgen receptor
- We have designed and initiated a phase 2 clinical trial of lapatinib, the dual EGFR/HER-2 inhibitor, in patients with hormone refractory prostate cancer
Awards and Honors
- NIH K08 Physician Scientist Award, 2000
- Department of Defense Prostate Cancer Research Program New Investigator Award, 2000
- Glaxo Wellcome Junior Faculty Award in Prostate Cancer Research, 1999
News and Stories
Q&A: the link between body weight and cancer
Young Whang, MD, PhD, a UNC Health medical oncologist, and Sarah Ro, MD, a UNC Health weight management physician, answer questions about the link between excess body weight and cancer.