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130 Mason Farm Road
Chapel Hill, NC 27514 United States Get Directions
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Biochemistry & Biophysics Seminar: Strategies to target the mTORC1/eIF4F Axis in B-cell malignancies

Bioinformatics, 1131 130 Mason Farm Road, Chapel Hill, NC, United States

David Fruman, PhD UC Irvine mTOR complex-1 (mTORC1) is a key regulator of B cell proliferation and differentiation. Elevated mTORC1 activity is also common in B cell cancers and is associated with poor prognosis. We have shown that eukaryotic initiation factor 4F (eIF4F) is a key mTORC1 effector pathway in the activation and differentiation of … Read more