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Pengda Liu, PhD, is a UNC Lineberger Comprehensive Cancer Center member and assistant professor in the Department of Biochemistry and Biophysics at UNC-Chapel Hill.

PhD
Assistant Professor, Department of Biochemistry and Biophysics
UNC-Chapel Hill
Cancer Cell Biology

Area of Interest

The Pengda Liu Lab is interested in deciphering the molecular mechanisms underlying aberrant signaling events that contribute to tumorigenesis mediated by protein modifications and protein-protein interactions. Understanding these events may lead to identification of novel drug targets and provide new treatment strategies to combat human cancer. To this end, we are interested in the potential of enzymes, and their inhibition, for generating traditional inhibitory chemical compounds or antibodies as potential therapeutic tools.

Cell signaling networks determine cell fate and aberrant activation of oncogenic signaling is a key mechanism during cancer development; however, cell-signaling networks are complicated and dynamic with fluxes in both space and time. Thus, to understand how cancer-associated aberrant cell decisions are made requires addressing the following questions through a global view of cell signaling networks, including to identify the key molecular events that lead to malignant diseases but do not occur in healthy cells and to elucidate how can cancer-associated signaling modules be targeted for cancer treatment.

Awards and Honors

  • Andrew McDonough B+ Foundation grant, 2022
  • Jefferson-Pilot Fellowships in Academic Medicine, UNC School of Medicine, 2021-2022
  • The Breast Cancer Alliance Young Investigator Grant, 2020
  • North Carolina Biotechnology Center Flash Grant, 2019-2020
  • Department of Defense Peer Reviewed Cancer Career Development Award, 2019-2022 (declined)
  • UNC Lineberger Development Award, 2019
  • Avantor Sciences Foundation Grant, 2019
  • vwr Charitable Foundation Grant, 2019
  • V Scholar, 2018
  • Atomwise AIMS Award, 2017
  • IBM Junior Faculty Development Award, 2017
  • East Carolina University 40 under 40 leadership award, 2016
  • K99/R00 NCI Pathway to Independence Award, 2014-2019
  • NIH/NCI Howard Temin Pathway to Independence Award in Cancer Research Award, 2014
  • T32 Postdoctoral Training Fellowship from the National Heart, Lung, and Blood Institute (NHLBI), NIH, 2012-2014
  • NIH/Ruth L. Kirschstein National Research Service Award (NRSA T32 Training Fellowship), 2012
  • Carol F. Volkman Award, 2006

Find publications on PubMed

News and Stories

Headshot of Pengda Liu