Area of interest
Current research projects in the Campbell laboratory include: redox regulation of Ras superfamily GTPases using kinetic and spectroscopic approaches; structural, biophysical and biochemical studies of wild type and variant Ras and Rho family GTPase proteins, ubiquitination of Ras as well as the identification, characterization and structural elucidation of factors that act on Ras and Rho family GTPase proteins. We are currently collaborating with the Der and Burridge laboratories to extrapolate molecular information with cell-based studies to better understand the molecular function of these GTPases.
Our laboratory employs a multidisciplinary approach to investigate these problems. While our main structural tool is high field NMR spectroscopy, we also employ other biophysical and biochemical methods including various computer modeling and computational approaches, fluorescence spectroscopy, biochemical characterization of binding interactions and enzyme activity. Most of our studies are conducted in collaboration with laboratories that focus on molecular and cellular biological aspects of these problems.
Awards and Honors
Hettleman award – 2001
Jefferson-Pilot award – 1998