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Thomas B. Alexander

Thomas B. Alexander, MD, MPH, is a UNC Lineberger Comprehensive Cancer Center member and Assistant Professor in the Department of Pediatrics at the University of North Carolina at Chapel Hill.

Assistant Professor Pediatrics
UNC-Chapel Hill
Clinical Research

Area of Interest

Thomas Alexander, MD, MPH, is combining cancer genomic sequencing with early phase clinical trials to enhance understanding of disease response dynamics and improve outcomes in childhood leukemia and other hematological malignancies. Alexander is currently investigating new cancer therapeutics and serves as co-investigator or principal investigator for several multi-institutional early phase clinical trials.

Currently, he is involved in testing efficacy of combined venetoclax and navitoclax therapy in patients with relapsed ALL or lymphoblastic lymphoma who are also receiving chemotherapy. He is the co-leader the Pediatric Oncology Developmental Therapeutics and Pharmacology Program at UNC. In the lab, Alexander is focused on exploring the biology of minimal residual disease in acute lymphoblastic leukemia, through RNA sequencing and epigenetic studies, at both a bulk and single cell level. The ultimate goal is to develop more rationale therapeutic targets for patients with persistent MRD.

Additionally, he is developing a project to explore a novel sequencing platform for cancer diagnostics, specifically with the goal of improving diagnostic capabilities in low and middle income counties. Alexander works extensively in all of these efforts with collaborators at UNC, including those at the Integrative Program for Biological and Genome Sciences, the Center of Gastrointestinal Biology and Disease, and the UNC Lineberger Comprehensive Cancer Center.

Awards and Honors

  • Carolina For The Kids Faculty Investigator Award, 2020-2021
  • St. Baldrick Research Award Grant, 2019-2020
  • American Society of Hematology – Abstract Achievement Award, 2016
  • Society for Hematologic Oncology – Young Investigator Travel Grant, 2015
  • WakeMed Pediatric Resident of the Year, 2012-2013
  • Harvey J. Hamrick Award for Excellence in Teaching – UNC Pediatrics, 2012-2013
  • Floyd W. Denny Alumni Society Resident Award – UNC Pediatrics, 2012-2013
  • Harvey J. Hamrick Award for Excellence in Teaching – UNC Pediatrics, 2010-2011

Find publications on PubMed