Senescent cells: mammalian aging drivers or in vitro laboratory artifact?
Marsico Hall, 4004 125 Mason Farm Road, Chapel Hill, NC, United StatesAndrei Gudkov, PhD, DSc Senior Vice President, Research Technology and Innovation Garman Family Chair, Cell Stress Biology Roswell Park Comprehensive Cancer Center Cellular senescence was initially defined as an in vitro phenomenon of DNA damage-induced irreversible proliferation arrest associated with constitutive production of pro-inflammatory factors. Aging of mammals has been attributed to accumulation of senescent … Read more