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UNC Lineberger
To reduce customer traffic to the facility along with the risk of interaction between customers, please email the PSC staff member working on your request to set up a time to drop-off and pick-up materials. Please identify drop-off items with your name, the PI name, and order number. Instead of a sign-out sheet, an email confirmation will be requested.

PSC Services

The Pathology Services Core may offer additional services not listed here. For more information, contact us by telephone at 919-843-3409 or by e-mail at nanan@med.unc.edu.

For Clinical Trials:

Please fill out the form below and attach it in ilabs when submitting a clinical trial related request:

Clinical Trial Request Form_UNC_LCCC_w_Instructions

 

Tissue Processing

Pull slides or blocks from UNCH archive

Tissue/cell line processing and embedding

FFPE tissue sectioning and coring

RNase free FFPE tissue sectioning and coring

De-Calcification

Tissue Micro Array (TMA)

TMA and Cell Line Array (CLA) design

TMA and CLA construction

TMA/CLA sectioning

Histochemical Stains

H&E

Special Stains:

Acid Fast Bacillus (AFB) Bielschowsky Carmine Colloidal Iron Congo Red
Cresyl Violet DAPI Fites Stain Giemsa Melanin Bleach
Methylene Blue Periodic Acid Schiff (PAS) Prussian Blue Phosphotungstic Acid Hematoxylin (PTAH) Rhodamine Copper
Safranin O Schmorl Sirius Red Sudan Black Von Kossa
Alcian Blue Alcian Blue – PAS Brown & Brenn Fontana Masson Grocott’s Methenamine Silver (GMS)
Luxol Fast Blue (LFB) LFB-PAS Martius Scarlet Blue Mayer’s Mucicarmine Masson Trichrome
Oil Red O Pico-Sirius Red Reticulin Sudan Black Verhoeff-Van Gieson (VVG)
Jones Basement Membrane Steiner Warthin Starry

IHC, IF and ISH

Automated IHC-single

Automated IF –double and triple

Automated IF –UltivueTM four marker multiplex

ISH (RNA) Chromogenic w/ Leica probes

ISH (RNA) chromogenic (single) or IF (single and multiplex) w/ RNAscope probes

NEW* – GeoMXTM Digital Spatial Profiler – up to 96 antibodies or 1000 RNA targets per slide

Whole Slide Scanning and Image Storage

Aperio ScanScope AT2, bright field

Aperio ScanScope FL, immunofluorescence

Versa, bright field and immunofluorescence

Aperio eSlide Manager, centralized image storage

Image Analysis (Aperio Toolbox and Genie, Definiens Tissue Studio, Visiopharm)

Tissue composition analysis

Cellular analysis

Image alignment (e.g. IF slide aligned with corresponding H&E for analysis)

Pathology

Pathology (MD) review for clinical trials or research