Clinical Trials

A listing of current lymphoma clinical trials available at UNC Lineberger Comprehensive Cancer Center.

Hodgkin Lymphoma

DiseaseStudy #Study Title and DescriptionPI
RelapsedLCCC1532-ATLPhase Ib/II Study of the Administration of T Lymphocytes Expressing the CD30 Chimeric Antigen Receptor (CAR) for Relapsed/Refractory CD30+ Hodgkin's Lymphoma and CD30+ Non-Hodgkin's LymphomaAnne Beaven, MD
RelapsedLCCC1524-ATLPhase I Study of the Administration of T Lymphocytes Expressing the CD30 Chimeric Antigen Receptor (CAR) for Prevention of Relapse of CD30+ Lymphomas After High Dose Therapy and Autologous Stem Transplantation (ATLAS)Thomas Shea, MD
Relapsed (HIV) AMC-095 A Phase I Study of Ipilimumab and Nivolumab in Advanced HIV Associated Solid Tumors with an Expansion Cohort in HIV Associated Solid Tumors and a Cohort of HIV-Associated Classical Hodgkin Lymphoma Michael Lee, MD

Non-Hodgkin Lymphoma (Multiple Subtypes)

DiseaseStudy #Study Title and DescriptionPI
Relapsed C34005 A Phase 1b, Dose Escalation Study to Determine the Recommended Phase 2 Dose of TAK-659 in Combination With Bendamustine (+/- Rituximab), Gemcitabine, Lenalidomide, or Ibrutinib for the Treatment of Patients With Advanced Non-Hodgkin Lymphoma After At Least 1 Prior Line of Therapy Christopher Dittus, DO, MPH

Mantle Cell Lymphoma

DiseaseStudy #Study Title and DescriptionPI
Frontline EA4151-CIRB A Randomized Phase III Trial of Consolidation with Autologous Hematopoietic Cell Transplantation Followed by Maintenance Rituximab vs. Maintenance Rituximab Alone for Patients with Mantle Cell Lymphoma In Minimal Residual Disease-Negative First Complete Remission Anne Beaven, MD

Follicular Lymphoma

DiseaseStudy #Study Title and DescriptionPI
Relapsed SGNS40-001 A phase 1, open-label, dose-escalation study of SEA-CD40 in adult patients with advanced malignancies Juneko Grilley-Olsen, MD

Diffuse large B-cell lymphoma (DLBCL)

DiseaseStudy #Study Title and DescriptionPI

Frontline

AMC-101A Pilot Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas (ARL)Christopher Dittus, DO, MPH

Any (HIV)

AMC-083Tissue Acquisition for Analysis of Prognostic Factors, Immunology, and Genetic Progression of HIV-1 Associated MalignanciesChristopher Dittus, DO, MPH

T-Cell Lymphoma

DiseaseStudy #Study Title and DescriptionPI

Frontline

LCCC1637

Brentuximab Vedotin with Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (BV-CHEP) for the treatment of Adult T-Cell Leukemia/Lymphoma: A Phase II Trial of the Rare Lymphoma Working Group Christopher Dittus, DO, MPH

EBV-Positive Lymphomas

DiseaseStudy #Study Title and DescriptionPI

Relapsed

EBV-CTL-201

Multicenter Expanded Access Protocol of Allogeneic Epstein-Barr Virus Cytotoxic T Lymphocytes (EBV-CTLs) for Patients with EBV-Associated Lymphomas and Lymphoproliferative Disorders in Immunocompromised Patients for Whom There are No Other Comparable Option Marcie Riches, MD, MS

 

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