UNC Lineberger News

Genetic pattern predicts response, metastasis in melanoma

Genetic pattern predicts response, metastasis in melanoma

A gene known to be mutated in many different cancers, but thought to be relatively unimportant in melanoma, may be a key indicator of how the disease will respond to radiation therapy and whether it will spread.

Genetic pattern predicts response, metastasis in melanoma - Read More…

Dibbert elected president of National Association of Cancer Center Development Officers

Dibbert elected president of National Association of Cancer Center Development Officers

Chapel Hill, NC – Debbie C. Dibbert, Director of External Affairs at UNC Lineberger Comprehensive Cancer Center, has been elected president of the National Association of Cancer Center Development Officers (NACCDO). She will serve a two-year term.

Dibbert elected president of National Association of Cancer Center Development Officers - Read More…

A Summer Final Four: Help Cornucopia House Win $25,000

A Summer Final Four: Help Cornucopia House Win $25,000

Votes, not baskets, will propel Cornucopia House to the Final Four in a national competition for a $25K mobile technology grant from AtlanticBT.

A Summer Final Four: Help Cornucopia House Win $25,000 - Read More…

Combination therapy for triple-negative breast cancer disappointing

Combination therapy for triple-negative breast cancer disappointing

CHAPEL HILL, N.C. – A recent clinical trial testing a combination therapy for basal-like (also known as triple-negative) breast cancer demonstrates that a combination of two drugs with promising preclinical results is not as effective as researchers had hoped.

Combination therapy for triple-negative breast cancer disappointing - Read More…

Gene inactivation drives spread of melanoma

Gene inactivation drives spread of melanoma

Chapel Hill, NC – Why do some cancers spread rapidly to other organs and others don’t metastasize? A team of UNC researchers led by Norman Sharpless, MD, have identified a key genetic switch that determines whether melanoma, a lethal skin cancer, spreads by metastasis.

Gene inactivation drives spread of melanoma - Read More…

Jennifer Bowman named Hometown Hero for June 11

Jennifer Bowman named Hometown Hero for June 11

WCHL named Jennifer Bowman a Hometown Hero for June 11, 2012. Each weekday the station selects a Hometown Hero who goes “over and above the call of duty,” exemplifying excellent service and dedication to others in the community.

Jennifer Bowman named Hometown Hero for June 11 - Read More…

Mayer appointed to term on Cancer Survivorship Committee

Mayer appointed to term on Cancer Survivorship Committee

Deborah Mayer, PhD, RN, AOCN, FAAN, associate professor in the UNC School of Nursing, has been appointed to a three-year term on the Cancer Survivorship Committee of the American Society of Clinical Oncology.

Mayer appointed to term on Cancer Survivorship Committee - Read More…

UNC Lineberger member Kurt Ribisl co-authors study assessing online alcohol sales to minors

UNC Lineberger member Kurt Ribisl co-authors study assessing online alcohol sales to minors

Kurt Ribisl, PhD, is co-author of the article “Internet Alcohol Sales to Minors” published online ahead of print in the May 2012 issue of the Archives of Pediatrics & Adolescent Medicine.

UNC Lineberger member Kurt Ribisl co-authors study assessing online alcohol sales to minors - Read More…

UNC Lineberger member James Evans quoted in Nature

UNC Lineberger member James Evans quoted in Nature

James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted in an article discussing the fetal genome and the possibility of clinic procedures being introduced in the next couple of years.

UNC Lineberger member James Evans quoted in Nature - Read More…

Bae-Jump receives grant to study impact of obesity on ovarian cancer

Bae-Jump receives grant to study impact of obesity on ovarian cancer

Victoria Bae-Jump, MD, PhD, has received a two-year $200,000 grant from the Department of Defense, to study “Preclinical and Clinical Investigations of the Impact of Obesity on Ovarian Cancer Pathogenesis.”

Bae-Jump receives grant to study impact of obesity on ovarian cancer - Read More…

N.C. Children's Hospital achieves high rankings in several specialties including cancer

Congratulations to the N.C. Children’s Hospital for receiving top rankings in 10 out of 10 clinical categories in U.S. News & World Report’s 2012-13 “America’s Best Children’s Hospitals” list. The N.C. Children’s Hospital is ranked 26th in cancer.

N.C. Children's Hospital achieves high rankings in several specialties including cancer - Read More…

Over 150 attend UNC Lineberger's annual scientific retreat

Over 150 attend UNC Lineberger's annual scientific retreat

More than 150 faculty, students, and fellows gathered in the Alumni Center to hear talks on HPV and Cancer given by UNC Lineberger scientists from basic, translational science, clinical, population science, and global perspectives.

Over 150 attend UNC Lineberger's annual scientific retreat - Read More…

Science, surgery, and start-ups - in depth with Dr. Nancy DeMore

Science, surgery, and start-ups - in depth with Dr. Nancy DeMore

UNC surgeon-scientist Dr. Nancy DeMore says, “As a physician, I’m acutely aware of how much more we need to learn about breast cancer and how urgently we need better therapies. It really gives me hope to be in the lab and to know that I’m working towards something that may make things better for patients.”

Science, surgery, and start-ups - in depth with Dr. Nancy DeMore - Read More…

UNC Oncology Chaplain Named North Carolina Chaplain of the Year

UNC Oncology Chaplain Named North Carolina Chaplain of the Year

Chapel Hill - Patricia Cadle, MRE, BCC, Oncology Chaplain at UNC Health Care’s Department of Pastoral Care, was honored as the 2012 Chaplain of the Year by the North Carolina Chaplains’ Association. This award is presented annually at the Association’s spring conference in recognition of “distinguished ministry in pastoral care” to a chaplain “who serves patients, community and colleagues with grace and innovation.”

UNC Oncology Chaplain Named North Carolina Chaplain of the Year - Read More…

BCBSNC Names Dr. Lisa Carey to Board of Trustees

BCBSNC Names Dr. Lisa Carey to Board of Trustees

CHAPEL HILL, N.C. – Blue Cross and Blue Shield of North Carolina (BCBSNC) has announced Dr. Lisa Carey, Medical Director of the University of North Carolina at Chapel Hill (UNC) Breast Center and Associate Director of UNC Lineberger Comprehensive Cancer Center, as the newest member of its board of trustees.

BCBSNC Names Dr. Lisa Carey to Board of Trustees - Read More…

Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers

Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers

Chapel Hill, NC – Multiple research projects – including a 2006 study conducted at the University of North Carolina at Chapel Hill – have used DNA microarray analysis to identify several breast cancer subtypes, including luminal A, luminal B, basal-like and HER2-enriched. Simple tests are being developed to help doctors identify these subtypes and to treat their patients in a more biologically-based way. In turn, these tests have made several studies possible that indicate that basal-like, or triple negative breast cancer, is more prevalent in African Americans than their Caucasian counterparts.

Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers - Read More…

Quest to understand Hepatitis C link with liver cancer receives $2.35 million boost

Quest to understand Hepatitis C link with liver cancer receives $2.35 million boost

Chapel Hill, NC – Does hepatitis C cause liver cancer due to inflammation associated with the disease, or does the virus interact with host cells in a different way to promote the development of cancer?

Quest to understand Hepatitis C link with liver cancer receives $2.35 million boost - Read More…

UNC study highlights diagnosis of lung cancer subtypes

UNC study highlights diagnosis of lung cancer subtypes

In the processes of treating most cancers, one of the key pieces of information is the appearance of the tumor under the microscope using a technique called light microscopy. In lung cancer, for example, the appearance of the tumor determines both which chemotherapies are safe and which chemotherapies are effective. In addition, tumor appearance also suggests which patients should be tested for mutations that can be targeted by some of the most effective and safest drugs on the market.

UNC study highlights diagnosis of lung cancer subtypes - Read More…

Bae-Jump to serve on NCI's Gynecologic Cancer Steering Committee

Bae-Jump to serve on NCI's Gynecologic Cancer Steering Committee

Victoria Bae-Jump, MD, PhD will serve a two-year term as a junior investigator on the Gynecologic Cancer Steering Committee of the National Cancer Institute, a member institute of the National Institutes of Health.

Bae-Jump to serve on NCI's Gynecologic Cancer Steering Committee - Read More…

Norman E. Sharpless, MD, appointed the Wellcome Distinguished Professor in Cancer Research

Norman E. Sharpless, MD, appointed the Wellcome Distinguished Professor in Cancer Research

Chapel Hill, NC – Norman E. “Ned” Sharpless, MD, professor of medicine and genetics and Associate Director for Translational Research at UNC Lineberger Comprehensive Cancer Center has been appointed the Wellcome Distinguished Professor in Cancer Research. The professorship was established by the School of Medicine in 1988 with gifts from the Burroughs Wellcome Fund and the William A. Smith Trust of Wadesboro, NC. The gifts were supplemented by the state of North Carolina the Distinguished Professors Endowment Trust Fund to create the endowed professorship.

Norman E. Sharpless, MD, appointed the Wellcome Distinguished Professor in Cancer Research - Read More…

Grant to fund use of kinase test in HER2-positive breast cancer

Grant to fund use of kinase test in HER2-positive breast cancer

Chapel Hill, NC – Susan G. Komen for the Cure® has awarded a grant of almost $900,000 to Lisa A. Carey, MD, and Gary Johnson, PhD, to research clinical applications for the first broad-based test for protein kinase activation and response to inhibitory drugs in HER2-positive breast cancer.

Grant to fund use of kinase test in HER2-positive breast cancer - Read More…

DNA replication protein also has a role in mitosis, cancer

DNA replication protein also has a role in mitosis, cancer

The finding presents a possible explanation for why so many cancers possess not just genomic instability, but also more or less than the usual 46 DNA-containing chromosomes.

DNA replication protein also has a role in mitosis, cancer - Read More…

Molecular subtypes and genetic alterations may determine response to lung cancer therapy

Molecular subtypes and genetic alterations may determine response to lung cancer therapy

Chapel Hill - Cancer therapies targeting specific molecular subtypes of the disease allow physicians to tailor treatment to a patient’s individual molecular profile. But scientists are finding that in many types of cancer the molecular subtypes are more varied than previously thought and contain further genetic alterations that can affect a patient’s response to therapy.

Molecular subtypes and genetic alterations may determine response to lung cancer therapy - Read More…

Study shows benefit of new maintenance therapy for multiple myeloma

Study shows benefit of new maintenance therapy for multiple myeloma

Chapel Hill, NC – Multiple myeloma is a form of cancer where the plasma cells in the bone marrow grow out of control, causing damage to bones as well as predisposing patients to anemia, infection and kidney failure. A medical procedure called autologous hematopoietic stem cell transplantation, commonly known as a stem cell transplant, is frequently an important treatment option for many patients.

Study shows benefit of new maintenance therapy for multiple myeloma - Read More…

UNC Bone Marrow and Stem Cell Transplantation Program achieves outstanding outcomes

Chapel Hill, NC –A medical procedure called allogeneic hematopoietic cell transplantation, commonly known as a bone marrow or stem cell transplant, is the only known curative option for many patients with life-threatening blood-borne cancers such as leukemia and lymphoma.

UNC Bone Marrow and Stem Cell Transplantation Program achieves outstanding outcomes - Read More…

Thriving on science: in depth with Jason Lieb

Thriving on science: in depth with Jason Lieb

Jason Lieb likes to mix it up. A triathlete, he enjoys running, swimming and cycling. In his lab, he works in several model systems: yeast, round worms (C. elegans), fruit flies (Drosophila melanogaster) and human cell lines.

Thriving on science: in depth with Jason Lieb - Read More…

Postdoctoral fellow receives DOD Visionary Fellowship Award

Postdoctoral fellow receives DOD Visionary Fellowship Award

Idoia Garcia, PhD, a postdoctoral fellow in the lab of Timothy Gershon, MD, PhD, has been awarded a Department of Defense Visionary Postdoctoral Fellowship Award. The peer-reviewed award is intended to support exceptionally talented recent medical or other doctoral graduates in their pursuit of cutting-edge, innovative, high-risk/high-impact cancer research during their postdoctoral fellowship.

Postdoctoral fellow receives DOD Visionary Fellowship Award - Read More…

Der receives grant funding for pancreatic cancer research

Der receives grant funding for pancreatic cancer research

Channing Der, PhD, Sarah Graham Kenan Professor of Pharmacology, received a two-year $200,000 American Association for Cancer Research Innovative grant from the Pancreatic Cancer Action Network. His grant will fund research on the mechanism of ERK inhibition resistance and ERK-dependent pancreatic cancer.

Der receives grant funding for pancreatic cancer research - Read More…

UNC scientist reports ways to improve breast cancer biomarker test

UNC scientist reports ways to improve breast cancer biomarker test

American and Spanish researchers report potential ways for doctors to improve the treatment of hormone receptor-positive breast cancer even if they lack access to costly multi-gene tests.

UNC scientist reports ways to improve breast cancer biomarker test - Read More…

Review study makes recommendations to enhance Cancer Comparative Effectiveness Research

Which treatment for prostate cancer is most effective? Will a specific combination of cancer drugs increase patient survival for colon cancer? As the pace of scientific discovery continues to accelerate, patients and their providers face more choices and decisions about how to address their health care needs, and information that can help inform their decisions is often hard to find.

Review study makes recommendations to enhance Cancer Comparative Effectiveness Research - Read More…

Stem cells poised to self-destruct for the good of the embryo

Stem cells poised to self-destruct for the good of the embryo

Embryonic stem cells are primed to kill themselves if damage to their DNA makes them a threat to the developing embryo. UNC researchers reveal how they do it.

Stem cells poised to self-destruct for the good of the embryo - Read More…

DeSimone elected into National Academy of Sciences

DeSimone elected into National Academy of Sciences

Dr. Joseph DeSimone, PhD, Chancellor's Eminent Professor of Chemistry at the University of North Carolina at Chapel Hill, has been elected into the National Academy of Sciences, one of the highest honors that a U.S. scientist or engineer can receive.

DeSimone elected into National Academy of Sciences - Read More…

Milowsky comments on new therapies for bladder cancer

Milowsky comments on new therapies for bladder cancer

Matthew Milowsky, MD, was recently quoted in the online journal Health News Digest on new therapies for bladder cancer.

Milowsky comments on new therapies for bladder cancer - Read More…

Joseph S. Pagano receives 2012 Battle Distinguished Cancer Research Award

Joseph S. Pagano receives 2012 Battle Distinguished Cancer Research Award

Joseph S. Pagano, MD, has been awarded the fifth annual Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research. Dr. Pagano is the director emeritus of UNC Lineberger Comprehensive Cancer Center.

Joseph S. Pagano receives 2012 Battle Distinguished Cancer Research Award - Read More…

UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery

UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery

Current nanomedicine research has focused on the delivery of established and novel therapeutics. But a UNC team is taking a different approach.

UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery - Read More…

36th Annual UNC Lineberger Scientific Symposium

UNC Lineberger’s 36th annual scientific symposium drew large crowds, with over 450 participants.

36th Annual UNC Lineberger Scientific Symposium - Read More…

Armistead receives Mentored Clinical Scientist Development Award

Armistead receives Mentored Clinical Scientist Development Award

Paul Armistead, MD, PhD, has received a grant of more than $396,000 from the National Heart, Lung and Blood Institute (part of the National Institutes of Health) to study leukemia stem cell-associated minor histocompatibility antigens.

Armistead receives Mentored Clinical Scientist Development Award - Read More…

UNC junior’s research honored at American Association for Cancer Research meeting

UNC junior’s research honored at American Association for Cancer Research meeting

UNC junior Molly DeCristo attended her first international scientific meeting, but not just as a participant. The American Association for Cancer Research (AACR) honored her poster with a rosette, judging it as “highly rated,” among the top 2.5 percent of those submitted.

UNC junior’s research honored at American Association for Cancer Research meeting - Read More…

Joyce Wilson: On Trips of a Lifetime, Planned and Unplanned

A Wayne County woman doesn’t let cancer, its treatment or its recurrence get in the way of her plans to attend her oldest granddaughter’s high school graduation or her own 45th high school reunion.

Joyce Wilson: On Trips of a Lifetime, Planned and Unplanned - Read More…

Intensity Modulated Radiation Therapy optimal for localized prostate cancer

Chapel Hill - A treatment for localized prostate cancer known as Intensity Modulated Radiation Therapy (IMRT) is better than conventional conformal radiation therapy (CRT) for reducing certain side effects and preventing cancer recurrence, according to a study published in the April 18, 2012 issue of the Journal of the American Medical Association. In 2012, approximately 241,740 American men will be diagnosed with prostate cancer.

Intensity Modulated Radiation Therapy optimal for localized prostate cancer - Read More…

International panel recommends new model for breast cancer care

CHAPEL HILL, N.C. - As the number of breast cancer survivors increases, now estimated at 2.8 million, more will be living with the chronic effects of cancer treatments or with advanced disease.

International panel recommends new model for breast cancer care - Read More…

Coghill receives grant to study graft versus host disease

Coghill receives grant to study graft versus host disease

James Coghill, MD, has received a grant of more than $529,000 from the National Heart, Lung and Blood Institute (part of the National Institutes of Health) to study a promising target for new therapies to combat graft versus host disease, a serious complication of treatment for many blood cancers.

Coghill receives grant to study graft versus host disease - Read More…

UNC scientists describe protein that protects against colon cancer

Chapel Hill - A family of proteins is yielding new information about how it contributes to the development of gastrointestinal disease and cancer. A team of UNC scientists reports that in pre-clinical models, the absence of a protein called NLRP12 significantly increases susceptibility to colitis-associated colon cancer.

UNC scientists describe protein that protects against colon cancer - Read More…

Three-dimensional RNA modeling opens scientific doors

Chapel Hill, NC – In a paper published today in the journal Nature Methods, a team from the University of North Carolina at Chapel Hill demonstrates a simple, cost-effective technique for three-dimensional RNA structure prediction that will help scientists understand the structures, and ultimately the functions, of the RNA molecules that dictate almost every aspect of human cell behavior. When cell behavior goes wrong, diseases – including cancer and metabolic disorders – can be the result.

Three-dimensional RNA modeling opens scientific doors - Read More…